Amide bond formation is often described simply as the “condensation of a carboxylic acid with an amine,” yet the actual experimental outcome depends primarily on what kind of activated intermediate the carboxylic acid is first converted into. Different activated intermediates can differ ...
In pharmaceuticals and fine chemicals, many molecules are chiral: the same molecular formula and connectivity may exist as two non-superimposable mirror-image forms (enantiomers). (With only one stereogenic center, there is usually one enantiomeric pair; with multiple stereocenters, multiple ...
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