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Topic

Click Chemistry

Browse protocols, FAQs, guidelines, and technical articles tagged “Click Chemistry”, newest first. For research use only.

36 resources · protocols, FAQs, guidelines & articles
Article

Click Chemistry and Its Future Application Prospects

The 2022 Nobel Prize in Chemistry was awarded to American scientists Carolyn R. Bertozzi, K. Barry Sharpless, and Danish scientist Morten Meldal in recognition of their contributions to the development of click chemistry and bioorthogonal chemistry. These three scientists pioneered a brand-new ...

Updated ·8 min read
Protocol

Tris(3-hydroxypropyltriazolylmethyl)amine(THPTA)

Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is a water-soluble ligand, is widely used to promote Cu-catalyzed alkyneazide cyclization (CuAAC), the typical bioorthogonal reaction with non-interference in living systems.

Updated ·2 min read
Protocol

Azide-Alkyne Click Chemistry

Classic Click Chemistry uses copper, Cu(I), to catalyze the 1,3-dipolar cycloaddition of an alkyne with an azide to form a 1,2,3-triazole.1,2 Sources of Cu(I) include copper(I) iodide, copper(I) bromide, copper turnings, or copper (II) sulfate (CuSO4) and a reducing agent.1 However, the ...

Updated ·5 min read
Article

Strain-promoted alkyne-nitrone cycloaddition (SPANC)

SPAAC can be carried out efficiently. On the one hand, the chemical potential energy of azide and alkyne substrates as reactants is very high. Diaryl-strained-cyclooctynes, such as dibenzylcyclooctyne (DIBO), have found application in reacting with 1,3-nitrones in strain-promoted alkyne-nitrone ...

Updated ·4 min read
Article

The application of click chemistry in chemical ligation and peptide modification

Connecting multiple peptide fragments to form an extended peptide chain is referred to as ligation. Click chemistry offers a convenient method for creating peptide-peptide linkages. By introducing an alkyne group to one peptide fragment and an N-terminal azide moiety to another, a triazole ...

Updated ·5 min read
Article

Potential Applications in Click Chemistry

Click Chemistry serves as a potent technique for investigating the intracellular distribution of small molecules. Unveiling the precise cellular destinations of these compounds provides profound insights into their mechanisms of action. This methodology has been extensively employed in various ...

Updated ·5 min read
Article

Strain-promoted azide-alkyne cycloaddition (SPAAC)

As a prevalent click reaction, strain-promoted alkyne-azide cycloaddition (SPAAC) operates without the need for metal catalysts, reducing agents, or enduring ligands. Instead, it harnesses the enthalpy liberated from the inherent ring strain of cyclooctyne to facilitate the formation of stable ...

Updated ·4 min read
Article

Reactions of strained alkenes in click chemistry

Strained alkenes leverage strain relief as a motivating factor, enabling their engagement in click reactions. Trans-cycloalkenes, typically cyclooctenes, and other strained alkenes like oxanorbornadiene, participate in click reactions with various counterparts, including azides, tetrazines, and ...

Updated ·4 min read
Article

Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)

The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition that involves the reaction between an azide and a terminal or internal alkyne, leading to the formation of a 1,2,3-triazole. Rolf Huisgen was a trailblazer in understanding the wide applicability of this organic reaction.

Updated ·6 min read
Article

Click Chemistry in Drug Discovery

Among the click chemical reaction family, the most interesting one may be the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between terminal alkynes and organic azides (Huisgen reaction) to produce 1,4-disubstituted 1,2,3-triazoles (Scheme 1).As a "good" click reaction, this reaction is ...

Updated ·3 min read
Article

Click Chemistry

Click chemistry is a new approach to synthesizing drug-like molecules that can accelerate the drug discovery process by utilizing a number of practical and reliable reactions. Chemist K B Sharpless and colleagues define a click reaction as one that is wide-ranging, easy to perform, uses only ...

Updated ·4 min read

Related topics

Topics that share resources with this page.

Fluorescent probes · 1 shared Cell imaging · 1 shared Bioorthogonal Labeling · 1 shared TAMRA Dye · 1 shared Bioconjugation · 10 shared Boc-Protected Amines · 1 shared Azide Reagents · 4 shared Linker Molecules · 1 shared Boc protection · 1 shared Bifunctional Linkers · 1 shared Organic synthesis · 2 shared Lab Safety · 1 shared Aromatic Azides · 1 shared Photoaffinity Labeling · 1 shared Bioorthogonal Chemistry · 6 shared Glycobiology · 1 shared Metabolic Glycan Labeling · 1 shared Azide Sugar · 1 shared O-GalNAc Glycosylation · 1 shared metabolic labeling · 1 shared azido sugar · 1 shared glycan labeling · 1 shared Lab Protocol · 1 shared Heterocyclic Amine · 1 shared synthetic building block · 1 shared Terminal Alkyne · 4 shared Heterocyclic Building Blocks · 1 shared Medicinal Chemistry · 2 shared Alkyne Reagents · 1 shared Coupling Reactions · 1 shared Tetrazole · 2 shared heterocyclic chemistry · 2 shared Synthetic Intermediates · 1 shared Thiophene Derivatives · 1 shared Terminal Alkynes · 1 shared Aldehyde Building Blocks · 1 shared Heterocyclic compound · 1 shared alkyne · 6 shared Thiophene · 1 shared Building Block · 1 shared Aldehyde · 1 shared synthetic reagent · 2 shared aromatic compound · 2 shared Sonogashira Coupling · 3 shared SPAAC · 3 shared PEGylation · 1 shared DBCO Chemistry · 1 shared Bioorthogonal Conjugation · 1 shared Maleimide Crosslinker · 1 shared aryl halide · 1 shared PEG Linker · 5 shared azide reagent · 2 shared Surface Functionalization · 1 shared PEG Linkers · 3 shared Oxime Ligation · 1 shared ADC Synthesis · 1 shared Methyl Ester · 1 shared Protein labeling · 1 shared NHS Ester · 1 shared MOF Synthesis · 1 shared carboxylic acid linker · 1 shared alkyne reagent · 1 shared organic building block · 1 shared BCN Reagent · 1 shared BCN Reagents · 2 shared amine reactive · 1 shared tetrazine ligation · 1 shared Biotin Labeling · 1 shared CuAAC · 2 shared THPTA · 1 shared Bioorthogonal reaction · 1 shared THPTA Ligand · 1 shared Azide-Alkyne Click Chemistry · 1 shared Click Reagent · 4 shared Bioorthogonal · 5 shared Nitrone · 1 shared SPANC · 1 shared azide · 4 shared Triazole · 1 shared CuCCA · 1 shared Azide Compound · 1 shared Tetrazine · 1 shared Click Reagen · 1 shared Copper catalyzed · 1 shared
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