Lipopolysaccharide

The uses of natural biological components derived from Escherichia coli in life science research are not limited to endotoxin stimulation. From native enzymatic readouts and host-background control in immunoassays, to pattern-recognition receptor activation in inflammatory models, and further to ...

Endotoxin commonly refers to lipopolysaccharide (LPS) enriched in the outer leaflet of the outer membrane of Gram-negative bacteria.

Lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria, binds to the TLR4 receptor and its co-receptors (e.g., CD14, MD-2) on macrophages, activating NF-κB, MAPK, and other pathways and inducing production/secretion of inflammatory cytokines such as TNF-α, ...

To efficiently remove endotoxins (lipopolysaccharides, LPS) from aqueous protein samples using the temperature-dependent phase separation property of Triton X-114, while retaining the target protein in the aqueous phase.

Lipopolysaccharides (LPS) are essential components of the outer membrane of Gram-negative bacteria, influencing bacterial survival and pathogenicity. LPS is located in the outer layer of the bacterial membrane and is directly exposed on the cell surface in non-capsulated strains. The complex ...