PROTACs (PROteolysis-TArgeting Chimeras) are heterobifunctional small molecules that induce targeted protein degradation. Each PROTAC molecule contains two distinct ligands: one is a target protein ligand that binds specifically to the intracellular protein of interest (POI), and the other is a ...
The anticancer drug Lenalidomide was once one of the world's top-selling small molecule drugs and orphan drugs, with sales of up to 9.978 billion US dollars in 2022, and its development company Celgene made huge profits.
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