Glucose metabolism is a core network for cellular energy conversion and carbon allocation, spanning glycolysis, gluconeogenesis, glycogen synthesis and breakdown, the pentose phosphate pathway, and the tricarboxylic acid (TCA) cycle.
In neoplastic cells, the de novo synthesis of nucleotides is responsible for maintaining sufficient nucleotide libraries to support DNA replication and RNA production. The metabolic pathways that support nucleotide production are dependent on metabolic intermediates provided by glycolysis and ...
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