Dinucleótido de flavina y adenina (FAD) - Moligand™, ≥97% , CAS No.146-14-5

CAS: 146-14-5 Cat. No.: F302909 Peso molecular: 785.5

GRADE & PURITY Moligand™, ≥97%

Synonyms

NSC 112207 | Adenina-riboflavina dinuceotida | DB03147 | flavitan | Riboflavina 5'-(trihidrógeno difosfato), P'->5'-éster con adenosina | F87829 | ZC44YTI8KK | ADENOSINA 5'-(TRIHIDRÓGENO PIRÓFOSFATO), 5'-5'-ESTER con RIBOFLAVINA | C00016 | Adenina-ribofla

Storage

Protegido de la luz,Almacenar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

Aplicación：

Grupo prostético de ciertas flavoproteínas, entre ellas la D-aminoácido oxidasa, la glucosa oxidasa, la glicina oxidasa, la fumar hidrogenasa, la histaminasa y la xantina oxidasa. Riboflavina cinasa receptor 1 del factor de necrosis tumoral NADPH oxidasa.

Specifications

Sinónimos

NSC 112207 | Adenina-riboflavina dinuceotida | DB03147 | flavitan | Riboflavina 5'-(trihidrógeno difosfato), P'->5'-éster con adenosina | F87829 | ZC44YTI8KK | ADENOSINA 5'-(TRIHIDRÓGENO PIRÓFOSFATO), 5'-5'-ESTER con RIBOFLAVINA | C00016 | Adenina-ribofla

Especificaciones y pureza

Moligand™, ≥97%

Condiciones de almacenamiento de almacenamiento

Protegido de la luz, Almacenar a -20°C

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Pureza

≥97%

Nombres e identificadores

• Pubchem Sid: 488190979
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488190979
• Sonrisas canónicas: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)O
• IUPAC Name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
• InChIKey: VWWQXMAJTJZDQX-UYBVJOGSSA-N
• INCHI: 1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1
• Isómeros SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](COP(=O)(O)OP(=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)O
• Peso molecular: 785.5
• Reaxy-Rn: 25843094
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25843094&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Clase Flavin nucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Clase: Flavin nucleotides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Flavin nucleotides
• Alternative Parents: (3'->5')-dinucleotides Purine ribonucleoside diphosphates Purine ribonucleoside monophosphates Flavins Pentose phosphates Glycosylamines 6-aminopurines Quinoxalines Monosaccharide phosphates Organic pyrophosphates Aminopyrimidines and derivatives Pyrimidones Monoalkyl phosphates Imidolactams Benzenoids N-substituted imidazoles Pyrazines Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Lactams Oxacyclic compounds Polyols Azacyclic compounds Hydrocarbon derivatives Primary amines Organopnictogen compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Flavin nucleotide - (3'->5')-dinucleotide - (3'->5')-dinucleotide or analogue - Purine ribonucleoside diphosphate - Purine ribonucleoside monophosphate - Flavin - Isoalloxazine - Pentose-5-phosphate - Pentose phosphate - Glycosyl compound - N-glycosyl compound - Diazanaphthalene - Pentose monosaccharide - Pteridine - 6-aminopurine - Quinoxaline - Organic pyrophosphate - Monosaccharide phosphate - Imidazopyrimidine - Purine - Monoalkyl phosphate - Aminopyrimidine - Pyrimidone - Monosaccharide - N-substituted imidazole - Organic phosphoric acid derivative - Imidolactam - Benzenoid - Alkyl phosphate - Phosphoric acid ester - Pyrimidine - Pyrazine - Tetrahydrofuran - Azole - Vinylogous amide - Heteroaromatic compound - Imidazole - Secondary alcohol - Lactam - Polyol - Oxacycle - Azacycle - Organoheterocyclic compound - Organic oxide - Organic oxygen compound - Organopnictogen compound - Organonitrogen compound - Hydrocarbon derivative - Primary amine - Alcohol - Amine - Organic nitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions.
• External Descriptors: flavin adenine dinucleotide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

HTT Tchem Huntingtin (19182 Activities)

Discover Target: HTT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)

Discover Target: KMT2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Helicobacter pylori (3113 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Moisture sensitive；Light sensitive
• Peso molecular: 785.500 g/mol
• XLogP3: -5.000
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 20
• Rotatable Bond Count: 13
• Exact Mass: 785.157 Da
• Monoisotopic Mass: 785.157 Da
• Topological Polar Surface Area: 356.000 Ų
• Heavy Atom Count: 53
• Formal Charge: 0
• Complexity: 1560.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 7
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Yan Shi, Wei Xu, Dawei Ni, Wenli Zhang, Cuie Guang, Wanmeng Mu.  (2023)  Identification and application of a novel deoxynivalenol-degrading enzyme from Youhaiella tibetensis.  FOOD CHEMISTRY,      [PMID:37783127] [10.1016/j.foodchem.2023.137609]

2. Xing-Jie Dai, Ying Liu, Ning Wang, He-Xiang Chen, Jiang-Wan Wu, Xiao-Peng Xiong, Shi-Kun Ji, Ying Zhou, Liang Shen, Shao-Peng Wang, Hong-Min Liu, Hui-Min Liu, Yi-Chao Zheng.  (2023)  Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:37542989] [10.1016/j.ejmech.2023.115684]

3. Liu Jianming, Zhang Han, Xu Yingying, Meng Hao, Zeng An-Ping.  (2023)  Turn air-captured CO2 with methanol into amino acid and pyruvate in an ATP/NAD(P)H-free chemoenzymatic system.  Nature Communications,  14  (1): (1-12).  [PMID:37188719] [10.1038/s41467-023-38490-w]

4. Yawen Liu, Hao Ma, Junqi Zhao, Jihong Wang, Xiaoxia Han, Bing Zhao.  (2023)  Surface-Enhanced Raman Spectroscopic Analysis of Flavoenzyme Cofactors: Guidance for Flavin-Related Bio- and Chemo- Sensors.  Chemosensors,  11  (3): (190).  [PMID:] [10.3390/chemosensors11030190]

5. Hui-Min Liu, Xiao-Peng Xiong, Jiang-Wan Wu, He-Xiang Chen, Ying Zhou, Shi-Kun Ji, Xing-Jie Dai, Yi-Chao Zheng, Hong-Min Liu.  (2023)  Discovery of acridine-based LSD1 inhibitors as immune activators targeting LSD1 in gastric cancer.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:36913900] [10.1016/j.ejmech.2023.115255]

6. Xing-Jie Dai, Li-Juan Zhao, Long-Hua Yang, Ting Guo, Lei-Peng Xue, Hong-Mei Ren, Zhi-Li Yin, Xiao-Peng Xiong, Ying Zhou, Shi-Kun Ji, Hui-Min Liu, Hong-Min Liu, Ying Liu, Yi-Chao Zheng.  (2023)  Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:36856685] [10.1021/acs.jmedchem.2c01593]

7. Peidong Du, Yanzhe Shen, Baoli Zhang, Shan Li, Minzheng Gao, Ting Wang, Xiaokang Ding, Bingran Yu, Zhen-Gang Wang, Fu-Jian Xu.  (2023)  A H2O2-Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment.  Advanced Science,  10  (9): (2206851).  [PMID:36709479] [10.1002/advs.202206851]

8. Hao Liu, Jun-Tao Zhang, Chen-Ye Mou, Yue Hao, Wei Cui.  (2022)  Involvement of DAAO Overexpression in Delayed Hippocampal Neuronal Death.  Cells,  11  (22): (3689).  [PMID:36429117] [10.3390/cells11223689]

9. Yan Li, Yutan Chu, Hongyu Sun, Qiongli Bao, Yizong Huang.  (2022)  Melatonin alleviates arsenite toxicity by decreasing the arsenic accumulation in cell protoplasts and increasing the antioxidant capacity in rice.  CHEMOSPHERE,      [PMID:36403814] [10.1016/j.chemosphere.2022.137292]

10. Yang Li, Zhenzhen Cheng, Chunlei Zhao, Cong Gao, Wei Song, Liming Liu, Xiulai Chen.  (2021)  Reprogramming Escherichia coli Metabolism for Bioplastics Synthesis from Waste Cooking Oil.  ACS Synthetic Biology,      [PMID:34337931] [10.1021/acssynbio.1c00155]

11. Yidong Zhou, Siyuan Gao, Mingliang Zhang, Wankui Jiang, Zhijian Ke, Jiguo Qiu, Jianhong Xu, Qing Hong.  (2021)  Unveiling the CoA mediated salicylate catabolic mechanism in Rhizobium sp. X9.  MOLECULAR MICROBIOLOGY,  116  (3): (783-793).  [PMID:34121246] [10.1111/mmi.14771]

12. Shuyun Ju, Mingxin Qian, Jing Li, Gang Xu, Lirong Yang, Jianping Wu.  (2019)  A biocatalytic redox cascade approach for one-pot deracemization of carboxyl-substituted tetrahydroisoquinolines by stereoinversion.  GREEN CHEMISTRY,  21  (20): (5579-5585).  [PMID:] [10.1039/C9GC02795E]

13. Hao Liu, Meng-Jing Zhao, Zi-Ying Wang, Qiao-Qiao Han, Hai-Yun Wu, Xiao-fang Mao, Yong-Xiang Wang.  (2019)  Involvement of d-amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice.  BRITISH JOURNAL OF PHARMACOLOGY,  176  (17): (3336-3349).  [PMID:31309542] [10.1111/bph.14764]

14. Shuyun Ju, Mingxin Qian, Gang Xu, Lirong Yang, Jianping Wu.  (2019)  Chemoenzymatic Approach to (S)-1,2,3,4-Tetrahydroisoquinoline Carboxylic Acids Employing D-Amino Acid Oxidase.  ADVANCED SYNTHESIS & CATALYSIS,  361  (13): (3191-3199).  [PMID:] [10.1002/adsc.201900178]

15. Chen Xin, Tang Hongzhi, Liu Yongdi, Xu Ping, Xue Yong, Lin Kuangfei, Cui Changzheng.  (2018)  Purification and Initial Characterization of 3-Hydroxybenzoate 6-Hydroxylase From a Halophilic Martelella Strain AD-3.  Frontiers in Microbiology,      [PMID:30034371] [10.3389/fmicb.2018.01335]

16. Yueyue Jing, Yulan Wang, Xinyi Wang, Chuan Song, Jiong Ma, Yonghui Xie, Yiyan Fei, Qinghua Zhang, Lan Mi.  (2017)  Label-free imaging and spectroscopy for early detection of cervical cancer.  Journal of Biophotonics,  11  (5): (e201700245).  [PMID:29205885] [10.1002/jbio.201700245]

17. Jia Xiaojing, Liu Ying, Han Yejun.  (2017)  A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate.  Scientific Reports,  7  (1): (1-10).  [PMID:28659601] [10.1038/s41598-017-04684-8]

18. Meng Yan, Hun Xu, Zhang Yue, Luo Xiliang.  (2016)  Toehold-aided DNA recycling amplification using hemin and G-quadruplex reporter DNA on magnetic beads as tags for chemiluminescent determination of riboflavin.  MICROCHIMICA ACTA,  183  (11): (2965-2971).  [PMID:] [10.1007/s00604-016-1937-x]

19. Yang Yuanyuan, Lin Jinping, Wei Dongzhi.  (2016)  Heterologous Overexpression and Biochemical Characterization of a Nitroreductase from Gluconobacter oxydans 621H.  MOLECULAR BIOTECHNOLOGY,  58  (6): (428-440).  [PMID:27138989] [10.1007/s12033-016-9942-1]

20. Lili Zhao, Shuhua Zhu, Jie Zhou.  (2012)  A novel amperometric nitric oxide sensor based on imprinted microenvironments for controlling metal coordination.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2012.05.035]

21. Shuping Zhang, Zhenhua Liu, Jia Li, Qian Liu, Yongqing Zhang, Gaobin Pu.  (2025)  Cloning and functional verification of Geraniol-10-Hydroxylase gene in Lonicera japonica.  PeerJ,      [PMID:39822969] [10.7717/peerj.18832]

22. Kai Yang, Zhenjie Tang, Chong Zhang, Ruide Zhang, Sheng Hu, Changjiang Lv, Jun Huang, Jiaqi Mei, Weirui Zhao, Lehe Mei.  (2025)  Developing a highly efficient 4-hydroxyphenylacetate-3-hydroxylase for salvianic acid A synthesis by computer-aided molecular modification.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39864709] [10.1016/j.ijbiomac.2025.140313]

23. Bo Wang, Shu-Wu Wang, Ying Zhou, Shao-Peng Wang, Ya Gao, Hui-Min Liu, Shi-Kun Ji, Sai-Qi Wang, Yi-Chao Zheng, Cheng Zhang, Adil Mardinoglu, Hong-Min Liu, Xiao-Bing Chen, Xing-Jie Dai.  (2024)  Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39264726] [10.1021/acs.jmedchem.4c00972]

24. Yanhong Niu, Zhili Wu, Qianfang Hu, Yuchen Wu, Qihua Jiang, Xiaolan Yang.  (2024)  Discovery of acetohydroxyacid synthase inhibitors as anti-tuberculosis lead compounds from natural products.  BIOORGANIC & MEDICINAL CHEMISTRY,      [PMID:39708691] [10.1016/j.bmc.2024.118041]

25. Chenyu Song, Wei Xu, Cuie Guang, Ting Xue, Wanmeng Mu.  (2024)  Identification and application of a novel patulin degrading enzyme from Cyberlindnera fabianii.  FOOD RESEARCH INTERNATIONAL,      [PMID:39147475] [10.1016/j.foodres.2024.114846]

26. Han-Yu Liu, Pan Ning, Feng Qian, Yao-Wu Wang, Hai-Min Zhang, Pu Wang.  (2024)  Protein Scaffold-Mediated Multi-Enzyme Self-Assembly and Ordered Co-Immobilization of Flavin-Dependent Halogenase-Coenzyme Cycle System for Efficient Biosynthesis of 6-Cl-L-Trp.  BIOTECHNOLOGY AND BIOENGINEERING,      [PMID:39468420] [10.1002/bit.28871]

27. Sile Deng, Xiaoju Men, Muhua Hu, Xiao Liang, Yujuan Dai, Zhengkun Zhan, Zhongchao Huang, Haobin Chen, Zhuxin Dong.  (2024)  Ratiometric fluorescence sensing NADH using AIE-dots transducers at the point of care.  BIOSENSORS & BIOELECTRONICS,      [PMID:38308942] [10.1016/j.bios.2024.116082]

28. Ye Zifan, Fu Lei, Li Shuangyu, Chen Ziying, Ouyang Jianhong, Shang Xinci, Liu Yanli, Gao Lianghui, Wang Yipeng.  (2024)  Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.  Nature Communications,  15  (1): (1-26).  [PMID:39183339] [10.1038/s41467-024-51730-x]

29. Han-Yu Liu, Feng Qian, Hai-Min Zhang, Qian Gui, Yao-Wu Wang, Pu Wang.  (2024)  Tri-enzyme fusion of tryptophan halogenase achieves a concise strategy for coenzyme self-sufficiency and the continuous halogenation of L-tryptophan.  Biotechnology Journal,  19  (4): (2300557).  [PMID:38581092] [10.1002/biot.202300557]

30. Hongxin Zhang, Junxia Liu, Fred Mwabulili, Peng Li, Xiao Li, Yanli Xie, Yuhui Yang, Qian Li, Weibin Ma, Hang Jia, Yuan Tian.  (2025)  The expression, identification, and application of DsDDH: a dehydrogenase from Devosia sp. 63-57 for the biodegradation of deoxynivalenol.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107293]

31. Yan Hai, Yunxing Zhao, Yao Wang, Zhiqiang Wang, Ting Li, Jianfeng Zhang, Jing Liang.  (2025)  Construction of a Cold-Resistant Shelter: Assembly of Bacteria on Hierarchical Porous Material for Low-Temperature Phenol Bio-degradation and Machine Learning Prediction.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.137840]

32. Qian Zhu, Kangning Wei, Kaihua Pan, Gang Hu, Weihao Zhu, Yanni Huang, Changchang Wang, Qian Li, Mingliang Zhang, Jiguo Qiu, Qing Hong.  (2025)  Identification of a novel ipp gene cluster responsible for 2-isopropylphenol degradation in strain Rhodococcus sp. D-6.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,      [PMID:40810535] [10.1128/aem.00995-25]

33. Haiyue Chen, Jun Xu, Han Shi, Xinle Liang, Wenjie Wang.  (2025)  Novel FAD-dependent uricase produced by food-sourced Priestia megaterium and activity assessment using hyperuricemia Caenorhabditis elegans.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40997969] [10.1016/j.ijbiomac.2025.147868]

34. Yidong Zhou, Zhijian Ke, Hangting Ye, Mengting Hong, Yifei Xu, Mingliang Zhang, Wankui Jiang, Qing Hong.  (2020)  Hydrolase CehA and a Novel Two-Component 1-Naphthol Hydroxylase CehC1C2 are Responsible for the Two Initial Steps of Carbaryl Degradation in Rhizobium sp. X9.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:33264024] [10.1021/acs.jafc.0c03845]

35. Hang Zhang, Yujie Zhang, Yinping Geng, Xuanlong Zhen, Xiaodi Wang, Qiange Yin, Peng Zhang, Yuanyuan Li, Mengzhen Zhang, Yi-chao Zheng, Bing-rui Liu, Hui-min Liu, Hai-wei Xu.  (2025)  The Exploration of Indole-Based LSD1-Targeted Inhibitors for Enhanced Immune Response in Gastric Cancer via the PD-L1/PD-1 Axis.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:40257403] [10.1021/acs.jmedchem.4c02851]

36. Ting Feng, Haoxian Huang, Ying Xu, Xinyu Che, Mingdong Wang, Xiangyu Tao, Yanbin Feng, Song Xue.  (2025)  Multisite synergistic evolution of oleate hydratase via DCCM and the orthogonal location of distal sites.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40379171] [10.1016/j.ijbiomac.2025.144001]

37. Xing-Jie Dai, Leipeng Xue, Ying Liu, Shu-Wu Wang, Ying Li, Jia-Yi Yin, Hao-Zhe Long, Hui-Min Liu, Ning Wang, Guo-Liang Lu, Yan Li, Hong-Min Liu, Bo Wang, Yi-Chao Zheng.  (2025)  Identification of Novel Phenoxazine-Derived LSD1 Inhibitors Suppressing Gastric Cancer Stemness by β-Catenin Transcriptional Regulation.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:41159872] [10.1021/acs.jmedchem.5c01798]

38. He Haisheng, Zhu Wenwei, Miao Han, Wang Shangfeng, Du Zunguo, Zhang Hongxin, Ming Jiang, Shi Ben, Wang Hao, Qi Jianping, Fan Yong, Wu Wei, Zhao Dongyuan, Qin Lun-Xiu, Zhang Fan.  (2026)  Label-free tissue NIR-II autofluorescence imaging for visualization of human liver malignancy.  Nature Biomedical Engineering,      [PMID:41559191] [10.1038/s41551-025-01593-4]