G140 - ≥98% , CAS No.2369751-07-3

CAS: 2369751-07-3 Cat. No.: G647730 Peso molecular: 379.24 PubChem CID: 139388865

GRADE & PURITY ≥98%

Synonyms

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone | T015T-010-1 | T015T-010-1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity

In Vitro

G140 (0.1-100 μM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC 50 s of 1.70 and 0.86?μM in human THP1 and primary macrophages, respectively. ?\nG140 (0.1-100 μM; 24 h) inhibits cells viability with a LD 50 of >100 μM in THP1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 14.0 nM (h-cGAS), 442 nM (m-cGAS)

Specifications

Sinónimos

1-(6, 7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3, 4-dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanone | T015T-010-1 | T015T-010-1

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0u2009nM and 442u2009nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
• IUPAC Name: 1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
• InChIKey: NVPFAXHXXODQRO-UHFFFAOYSA-N
• INCHI: 1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3
• Isómeros SMILES: CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
• PubChem CID: 139388865
• Peso molecular: 379.24

Objetivos asociados (humanos)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CGAS Tchem Cyclic GMP-AMP synthase (693 Activities)

Discover Target: CGAS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 250 mg/mL (659.21 mM; Need ultrasonic)