Gemcitabine hydrochloride - Moligand™,10mM in Water , DNA polymerase (alpha/delta/epsilon) inhibitor, CAS No.122111-03-9, DNA polymerase (alpha/delta/epsilon) inhibitor
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in Water
Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.This product is only used for scientific research.
Gemcitabine hydrochloride is used for treatment of non-small cell lung cancer, pancreatic cancer, mammary cancer, ovarian cancer, bladder cancer, nasopharyngeal carcinoma and non-Hodgkin's lymphoma.Deoxycytidine analog that inhibits DNA synthesis. Metabol
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
This compound belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. These are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2.
External Descriptors
hydrochloride - organofluorine compound
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Sensibilidad
Heat & Light sensitive
Índice de refracción
268
Rotación específica [α]
48°C
Punto de fusión (°C)
292°C
Peso molecular
299.660 g/mol
XLogP3
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
2
Exact Mass
299.048 Da
Monoisotopic Mass
299.048 Da
Topological Polar Surface Area
108.000 Ų
Heavy Atom Count
19
Formal Charge
0
Complexity
426.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
3
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
Referencias
1.Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2022) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2):[PMID:][10.1139/cjc-2022-0075]
2.Yu Wang, Hongrui Fan, Qinjun Chen, Haolin Song, Xuwen Li, Boyu Su, Tao Sun, Leilei Cheng, Chen Jiang. (2025) Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual disruption of pyrimidine synthesis and redox homeostasis in pancreatic ductal adenocarcinoma. BIOMATERIALS, [PMID:40818322][10.1016/j.biomaterials.2025.123630]
3.Zhe Zhang, Qitai Chen, Rujia Zheng, Zhenduo Shao, Xiaobao Wei, Xuanhao Gu, Yi Zang, Xishan Yang, Jiangchao Wu, Mengyao Dai, Wanyue Cao, Yangyang Wang, Yize Zhang, Chengyang Hu, Cao Chen, Linquan Wu, Tingbo Liang, Qi Zhang. (2025) Nano-enabled repurposing of Benproperine phosphate enhances pancreatic Cancer chemotherapy through lethal autophagy arrest and immune activation. JOURNAL OF CONTROLLED RELEASE, [PMID:40902670][10.1016/j.jconrel.2025.114187]
4.Yadong Tang, Boxin Huang, Yuqin Dong, Wenlong Wang, Xi Zheng, Wei Zhou, Kun Zhang, Zhiyun Du. (2017) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:28583017][10.1080/09205063.2017.1338502]
5.Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong-Hong Lee. (2025) CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1-Mediated Ubiquitination of NPM1. Advanced Science, [PMID:41114465][10.1002/advs.202510210]
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