Gly-Pro p-nitroanilide hydrochloride - ≥97% , CAS No.103213-34-9

CAS: 103213-34-9 Cat. No.: G331873 Peso molecular: 328.75 PubChem CID: 16219380

GRADE & PURITY ≥97%

Synonyms

Gly-Pro p-nitroanilide hydrochloride | GP-pNA, Chromogenic Substrate | J-000898 | FT-0726508 | AKOS037645284 | 1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride | AS-59672 | D93308 | SCHEMBL20214289 | DTXSID90585159 | 103213-34-9

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Gly-Pro-pNA hydrochloride is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX.

Specifications

Sinónimos

Gly-Pro p-nitroanilide hydrochloride | GP-pNA, Chromogenic Substrate | J-000898 | FT-0726508 | AKOS037645284 | 1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride | AS-59672 | D93308 | SCHEMBL20214289 | DTXSID90585159 | 103213-34-9

Especificaciones y pureza

≥97%

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥97%

Nombres e identificadores

• Pubchem Sid: 504768399
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768399
• Sonrisas canónicas: C1CC(N(C1)C(=O)CN)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-].Cl
• IUPAC Name: 1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride
• InChIKey: VBBFIBMVFSUUBP-UHFFFAOYSA-N
• INCHI: 1S/C13H16N4O4.ClH/c14-8-12(18)16-7-1-2-11(16)13(19)15-9-3-5-10(6-4-9)17(20)21;/h3-6,11H,1-2,7-8,14H2,(H,15,19);1H
• Isómeros SMILES: C1CC(N(C1)C(=O)CN)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-].Cl
• WGK Alemania: 3
• PubChem CID: 16219380
• Peso molecular: 328.75

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Proline and derivatives Alpha amino acid amides Anilides Nitrobenzenes Nitroaromatic compounds N-arylamides N-acylpyrrolidines Pyrrolidinecarboxamides Tertiary carboxylic acid amides Secondary carboxylic acid amides Organic oxoazanium compounds Azacyclic compounds Propargyl-type 1,3-dipolar organic compounds Organopnictogen compounds Organic zwitterions Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-dipeptide - Proline or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Nitrobenzene - Anilide - Nitroaromatic compound - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - N-arylamide - Monocyclic benzene moiety - Benzenoid - Pyrrolidine - Tertiary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - C-nitro compound - Organic nitro compound - Secondary carboxylic acid amide - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Azacycle - Organoheterocyclic compound - Organic oxoazanium - Hydrochloride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Amine - Organic oxide - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organopnictogen compound - Primary amine - Organic nitrogen compound - Organic zwitterion - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water (at least 150 mM).
• Sensibilidad: Moisture sensitive.
• Peso molecular: 328.750 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 328.094 Da
• Monoisotopic Mass: 328.094 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 415.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Ritian Jin, Chang Liu, Jing Song, Duo Liang, Rong Lin, Zhongyang Ren, Cheng Li, Jiaqi Shang, Shen Yang.  (2024)  Dynamic gastrointestinal digestion of tilapia (Oreochromis mossambicus) skin gelatin: changes of hydrolysate properties and dipeptidyl peptidase IV inhibitory activity.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:39723440] [10.1002/jsfa.14090]

2. Yuyang Liu, Yan Zhang, Minghao Liu, Sainan Yu, Zhenglin Tian, Wannan Li, Weiwei Han.  (2025)  Virtual Hydrolysis-Based Screening of Wheat-Derived DPP-IV Inhibitory Peptides: A Mechanistic Analysis Integrating Cell Experiments and Molecular Dynamics Simulations.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:40623964] [10.1021/acs.jafc.5c03006]

3. He Yi, Zhang Yan, Liu Minghao, Li Jiaying, Li Wannan, Han Weiwei.  (2025)  Deep learning-based dipeptidyl peptidase IV inhibitor screening, experimental validation, and GaMD/LiGaMD analysis.  BMC BIOLOGY,  23  (1): (1-17).  [PMID:40597132] [10.1186/s12915-025-02295-8]

4. Jingjie Tan, Sirong Huang, Dongjing Wu, Zhongquan Zhao, Yongju Zhao, Yu Fu, Wei Wu.  (2026)  AI-Driven Rapid Screening and Characterization of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Goat Blood Proteins: An Integrative In Silico and Experimental Strategy.  Foods,  15  (2): (398).  [PMID:41596996] [10.3390/foods15020398]

5. Minghao Liu, Shiying Li, Xue Zhou, Xueyan Duan, Xueqi Fu, Shu Xing, Weiwei Han.  (2026)  Virtual Screening and Validation of DPP-4 Inhibitory Peptides from Goat Milk: Insights from Molecular Dynamics Simulations and In vitro Experiment.  JOURNAL OF DAIRY SCIENCE,      [PMID:] [10.3168/jds.2025-27580]