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GNE 220 hydrochloride - ≥98% , CAS No.2448286-21-1
Disponible para pedir
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM.
In Vitro
GNE-220 also inhibits a few other kinases with IC 50 s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM + retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1 + long focal adhesions (FAs). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:MAP4K4 7 nM (IC 50 ) MAP4K5 9 nM (IC 50 ) MAP4K6 1.1 μM (IC 50 ) DMPK 476 nM (IC 50 )
Specifications
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Desiccated
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Pureza
≥98%
Nombres e identificadores
| Sonrisas canónicas | CC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C.Cl |
|---|---|
| IUPAC Name | 6-methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene;hydrochloride |
| InChIKey | VBVBAEHNBOTZQV-UHFFFAOYSA-N |
| INCHI | 1S/C25H26N8.ClH/c1-16-22-23(30-24(28-16)19-14-27-32(3)15-19)21-12-18(13-26-25(21)29-22)17-4-6-20(7-5-17)33-10-8-31(2)9-11-33;/h4-7,12-15H,8-11H2,1-3H3,(H,26,29);1H |
| PubChem CID | 134828260 |
| Peso molecular | 474.99 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Estructura 3D
Modelo de Estructura Química Interactiva
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 5.4 mg/mL (11.37 mM; Need ultrasonic) H2O : 5 mg/mL (10.53 mM; Need ultrasonic) |
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Calculadoras de soluciones
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