MAP4K

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  1. PF 06260933 dihydrochloride
    CAS: 1883548-86-4 PubChem CID: 118701007 Fórmula: C16H13ClN4.2HCl Peso molecular: 369.68
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: P288924
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    Nombre IUPAC
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine;dihydrochloride
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl.Cl.Cl
    InChIKey
    VRQXEOPUAQLBQI-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4.2ClH/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11;;/h1-9H,(H2,18,20)(H2,19,21);2*1H
    Sinónimos
    5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride
  2. TL4-12
    CAS: 1620820-12-3 PubChem CID: 134812827 Fórmula: C25H27F3N6O2 Peso molecular: 500.53
    ● En stock — EE. UU. Articulo #: T288817
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    Nombre IUPAC
    4-methyl-3-[6-(methylamino)pyrimidin-4-yl]oxy-N-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide
    SMILES
    CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC
    InChIKey
    HXKJJIMUMNPQQY-UHFFFAOYSA-N
    InChI
    1S/C25H27F3N6O2/c1-16-4-5-17(10-21(16)36-23-14-22(29-2)30-15-31-23)24(35)32-19-11-18(25(26,27)28)12-20(13-19)34-8-6-33(3)7-9-34/h4-5,10-15H,6-9H2,1-3Hshow more
    Sinónimos
    4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide
  3. NG25, Inhibitor of C-terminal Src kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase kinase kinase 7;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of SRC proto-oncoge
    CAS: 1315355-93-1 Número EC: 110-114-3 Fórmula: C29H30F3N5O2 Peso molecular: 537.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — EE. UU. Articulo #: N125272
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    Nombre IUPAC
    N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
    InChIKey
    SMPGEBOIKULBCT-UHFFFAOYSA-N
    InChI
    1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-1show more
    Sinónimos
    AC-35824 | Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]py...
  4. DMX-5084
    CAS: 2306178-56-1 Fórmula: C21H19N3O3 Peso molecular: 361.39
    10mM in DMSO
    ● En stock — EE. UU. Articulo #: D422736
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    Nombre IUPAC
    5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one
    SMILES
    COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4
    InChIKey
    FUSHFOGORKZNNQ-UHFFFAOYSA-N
    InChI
    1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25)
    Sinónimos
    4H-​Pyrrolo[2,​3-​d]​pyrimidin-​4-​one,3,​7-​dihydro-​5-​[4-​(2-​methoxyethoxy)​phenyl]​-​7-​phenyl-
  5. DMX-5084
    CAS: 2306178-56-1 Fórmula: C21H19N3O3 Peso molecular: 361.39
    ● En stock — EE. UU. Articulo #: D412287
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    Identificadores técnicos
    Nombre IUPAC
    5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one
    SMILES
    COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4
    InChIKey
    FUSHFOGORKZNNQ-UHFFFAOYSA-N
    InChI
    1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25)
    Sinónimos
    4H-​Pyrrolo[2,​3-​d]​pyrimidin-​4-​one,3,​7-​dihydro-​5-​[4-​(2-​methoxyethoxy)​phenyl]​-​7-​phenyl-
  6. NG25, Inhibitor of C-terminal Src kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase kinase kinase 7;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of SRC proto-oncoge
    CAS: 1315355-93-1 Número EC: 110-114-3 Fórmula: C29H30F3N5O2 Peso molecular: 537.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● En stock — EE. UU. Articulo #: N421221
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    Identificadores técnicos
    Nombre IUPAC
    N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
    InChIKey
    SMPGEBOIKULBCT-UHFFFAOYSA-N
    InChI
    1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-1show more
    Sinónimos
    AC-35824 | Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]py...
  7. NCB-0846
    CAS: 1792999-26-8 Fórmula: C21H21N5O2 Peso molecular: 375.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: N413998
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    Nombre IUPAC
    4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol
    SMILES
    C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5
    InChIKey
    FYWRWBSYRGSWIQ-UHFFFAOYSA-N
    InChI
    1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,2show more
    Sinónimos
    Cyclohexanol,4-​[[2-​(1H-​benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​,cis- | cis-4-((2-((1H-Benzo[d]imidazol...
  8. PF-6260933
    CAS: 1811510-56-1 PubChem CID: 118701008 Fórmula: C16H13ClN4 Peso molecular: 296.75
    10mM in DMSO
    ● En stock — EE. UU. Articulo #: P422224
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    Identificadores técnicos
    Nombre IUPAC
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
    InChIKey
    KHPCIHZXOGHCLY-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)
    Sinónimos
    PF-06260933[3,​3'-​Bipyridine]​-​6,​6'-​diamine,5-​(4-​chlorophenyl)​-
  9. PF-6260933
    CAS: 1811510-56-1 PubChem CID: 118701008 Fórmula: C16H13ClN4 Peso molecular: 296.75
    ● En stock — EE. UU. Articulo #: P413486
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    Identificadores técnicos
    Nombre IUPAC
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
    InChIKey
    KHPCIHZXOGHCLY-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)
    Sinónimos
    PF-06260933[3,​3'-​Bipyridine]​-​6,​6'-​diamine,5-​(4-​chlorophenyl)​-
  10. GNE-495
    CAS: 1449277-10-4 PubChem CID: 89730041 Fórmula: C22H20FN5O2 Peso molecular: 405.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: G646842
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    Nombre IUPAC
    8-amino-N-[1-(cyclopropanecarbonyl)azetidin-3-yl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
    SMILES
    C1CC1C(=O)N2CC(C2)NC(=O)C3=CN=C(C4=C3C=CC(=N4)C5=CC(=CC=C5)F)N
    InChIKey
    FYXCIBJXJYBWPX-UHFFFAOYSA-N
    InChI
    1S/C22H20FN5O2/c23-14-3-1-2-13(8-14)18-7-6-16-17(9-25-20(24)19(16)27-18)21(29)26-15-10-28(11-15)22(30)12-4-5-12/h1-3,6-9,12,15H,4-5,10-11H2,(H2,24,25)show more
    Sinónimos
    8-Amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
  11. TAK1/MAP4K2 inhibitor 1
    CAS: 1315330-11-0 PubChem CID: 71254032 Fórmula: C29H31F3N6O2 Peso molecular: 552.59
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: T648184
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    Identificadores técnicos
    Nombre IUPAC
    N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=NC=NC5=C4C=C(N5)C)C(F)(F)F
    InChIKey
    RWNAOXLCVXJMGM-UHFFFAOYSA-N
    InChI
    1S/C29H31F3N6O2/c1-4-37-9-11-38(12-10-37)16-21-7-8-22(15-24(21)29(30,31)32)36-27(39)20-6-5-18(2)25(14-20)40-28-23-13-19(3)35-26(23)33-17-34-28/h5-8,13show more
    Sinónimos
    AKOS016012030 | n-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methyl-3-((6-methyl-7h-pyrrolo[2,3-...
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Preguntas frecuentes

What can I find under MAP4K?
This listing collects compounds associated with MAP4K within our MAPK/ERK Pathway area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for MAP4K?
Consider the reported potency of each MAP4K compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for MAP4K compounds?
Each MAP4K product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search MAP4K compounds by activity or structure?
Yes. Filter the MAP4K listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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