Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 38 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| Pubchem Sid | 488184688 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184688 |
| Sonrisas canónicas | C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C |
| IUPAC Name | 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol |
| InChIKey | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
| INCHI | 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 |
| Isómeros SMILES | C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C |
| WGK Alemania | 3 |
| Número ONU | 3077 |
| Peso molecular | 266.33 |
| Reaxy-Rn | 1982052 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1982052&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Benzene and substituted derivatives |
| Subclass | Biphenyls and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Biphenyls and derivatives |
| Alternative Parents | 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Biphenyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond. |
| External Descriptors | Neolignans |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | May 27, 2026 | H111272 | |
| Certificate of Analysis | May 20, 2026 | H111272 | |
| Certificate of Analysis | May 16, 2026 | H111272 | |
| Certificate of Analysis | Feb 04, 2026 | H111272 | |
| Certificate of Analysis | Jan 31, 2026 | H111272 | |
| Certificate of Analysis | Jan 20, 2026 | H111272 | |
| Certificate of Analysis | Sep 16, 2025 | H111272 | |
| Certificate of Analysis | Sep 08, 2025 | H111272 | |
| Certificate of Analysis | Jun 16, 2025 | H111272 | |
| Certificate of Analysis | Nov 19, 2024 | H111272 | |
| Certificate of Analysis | Nov 19, 2024 | H111272 | |
| Certificate of Analysis | Apr 23, 2024 | H111272 | |
| Certificate of Analysis | Apr 02, 2024 | H111272 | |
| Certificate of Analysis | Apr 02, 2024 | H111272 | |
| Certificate of Analysis | Apr 02, 2024 | H111272 | |
| Certificate of Analysis | Aug 09, 2023 | H111272 | |
| Certificate of Analysis | Aug 09, 2023 | H111272 | |
| Certificate of Analysis | Feb 17, 2023 | H111272 | |
| Certificate of Analysis | Feb 17, 2023 | H111272 | |
| Certificate of Analysis | Feb 17, 2023 | H111272 | |
| Certificate of Analysis | Feb 17, 2023 | H111272 | |
| Certificate of Analysis | Feb 17, 2023 | H111272 |
| Solubilidad | Soluble in Methanol |
|---|---|
| Sensibilidad | Heat Sensitive |
| Punto de fusión (°C) | 85°C |
| Peso molecular | 266.300 g/mol |
| XLogP3 | 5.000 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 266.131 Da |
| Monoisotopic Mass | 266.131 Da |
| Topological Polar Surface Area | 40.500 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 325.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Fei Li, Chunyu Ye, Xiuli Wang, Xinting Li, Xiaoxia Wang. (2023) Honokiol ameliorates cigarette smoke-induced damage of airway epithelial cells via the SIRT3/SOD2 signalling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, [PMID:37795870] [10.1111/jcmm.17981] |
| 2. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, [PMID:37632730] [10.1021/acsami.3c06996] |
| 3. Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. (2023) Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. PHYTOTHERAPY RESEARCH, [PMID:37580045] [10.1002/ptr.7984] |
| 4. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu. (2023) Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms. Microorganisms, 11 (6): (1431). [PMID:37374932] [10.3390/microorganisms11061431] |
| 5. Yuan Hu, Miao Zhang, Bihan Liu, Yingying Tang, Zhuo Wang, Tao Wang, Jiaxin Zheng, Junjian Zhang. (2023) Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:36997099] [10.1016/j.freeradbiomed.2023.03.018] |
| 6. Meiying Ge, Guozheng Liang, Aijuan Gu. (2023) A facile strategy and mechanism to achieve biobased bismaleimide resins with high thermal-resistance and strength through copolymerizing with unique propargyl ether-functionalized allyl compound. REACTIVE & FUNCTIONAL POLYMERS, [PMID:] [10.1016/j.reactfunctpolym.2023.105570] |
| 7. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] [10.1002/ps.7431] |
| 8. Wang Yixi, Ding Chuanyang, Ge Zhangjie, Li Zhipeng, Chen Lixin, Guo Xiaolong, Dong Genxi, Zhou Ping. (2023) A novel antibacterial and fluorescent coating composed of polydopamine and carbon dots on the surface of orthodontic brackets. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 34 (2): (1-12). [PMID:36802301] [10.1007/s10856-023-06712-8] |
| 9. Qingcong Wei, Ziming Jin, Weiwei Zhang, Yanfei Zhao, Yaxing Wang, Yixing Wei, Xing He, Guanglei Ma, Yuming Guo, Yuqin Jiang, Zhiguo Hu. (2022) Honokiol@PF127 crosslinked hyaluronate-based hydrogel for promoting wound healing by regulating macrophage polarization. CARBOHYDRATE POLYMERS, [PMID:36657865] [10.1016/j.carbpol.2022.120469] |
| 10. Junzhao Yuan, Xiaoqian Huang, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. (2022) Honokiol reduces cadmium-induced oxidative injury and endosomal/lysosomal vacuolation via protecting mitochondrial function in quail (Coturnix japonica) liver tissues. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:36280083] [10.1016/j.scitotenv.2022.159626] |
| 11. Yuyan Zhu, Lixia Zhang, Xiyuan Zhou. (2022) Honokiol Improves Acne-like Lesions in a Rabbit Ear Model by Alleviating Hyperkeratosis and Sebum Secretion. Natural Product Communications, [PMID:] [10.1177/1934578X221126369] |
| 12. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang. (2022) Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy. Pharmaceutics, 14 (9): (1765). [PMID:36145512] [10.3390/pharmaceutics14091765] |
| 13. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. (2022) Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). JOURNAL OF FISH DISEASES, 45 (11): (1599-1607). [PMID:35801398] [10.1111/jfd.13683] |
| 14. Peng-Bo Duan, Ping-Ting Xiao, Xing Yang, Jin-Hua Hao, Kai Li, E-Hu Liu. (2022) Screening of hypoglycemic components in Platycladi Cacumen by phytochemical investigation, spectrum-effect relationship, and chemometric methods. JOURNAL OF SEPARATION SCIENCE, 45 (14): (2591-2602). [PMID:35593082] [10.1002/jssc.202200221] |
| 15. Hang Sun, Youjie Li, Xiao Wang, Xue Zhou, Simin Rong, Dongmin Liang, Guangbin Sun, Huizhen Cao, Hongfang Sun, Ranran Wang, Yunfei Yan, Shuyang Xie, Yunxiao Sun. (2022) TRIB2 regulates the expression of miR‑33a‑5p through the ERK/c‑Fos pathway to affect the imatinib resistance of chronic myeloid leukemia cells. INTERNATIONAL JOURNAL OF ONCOLOGY, 60 (5): (1-14). [PMID:35302171] [10.3892/ijo.2022.5339] |
| 16. Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. (2021) Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:34446208] [10.1016/j.pestbp.2021.104942] |
| 17. Jingwei Zhou, Yaoyao Hu, Peichun Chen, Hongwu Zhang. (2020) Preparation of restricted access monolithic tip via unidirectional freezing and atom transfer radical polymerization for directly extracting magnolol and honokiol from rat plasma followed by liquid chromatography analysis. JOURNAL OF CHROMATOGRAPHY A, [PMID:32709314] [10.1016/j.chroma.2020.461238] |
| 18. Qinglin He, Hua Yin, Jingjie Jiang, Yanfen Bai, Ning Chen, Shaowei Liu, Yibin Zhuang, Tao Liu. (2017) Fermentative Production of Phenolic Glucosides by Escherichia coli with an Engineered Glucosyltransferase from Rhodiola sachalinensis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:28547990] [10.1021/acs.jafc.7b00981] |
| 19. Jing Sun, Xueqi Fu, Ye Liu, Yongsen Wang, Bo Huo, Yidi Guo, Xuefeng Gao, Wannan Li, Xin Hu. (2015) Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice. Drug Design Development and Therapy, [PMID:26674084] [10.2147/DDDT.S92777] |
| 20. Ting Xu, Jie-Ru Meng, Wanqing Cheng, Jia-Zheng Liu, Junyan Chu, Qian Zhang, Nannan Ma, Li-Ping Bai, Yong Guo. (2022) Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, [PMID:35617790] [10.1016/j.bmc.2022.116838] |
| 21. Haonan Sun, Yumin Liu, Xuedong Wang, Luan Shu. (2024) A network pharmacology-based method to explore the therapeutic effect of honokiol on diabetes with comorbid depression in mice. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:38754538] [10.1016/j.ejphar.2024.176642] |
| 22. Zhang Chao, Wen Tingchi, Qiao Lijun, Guo Ming, Li Qihua, Lu Zhenghua, Zhu Zhenyuan, Lu Meiling. (2024) An environmentally safe formulation of plant derived fungicide: preparation and characterization of inclusion complex of honokiol and methyl-β-cyclodextrin. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, [PMID:] [10.1007/s10847-024-01265-x] |
| 23. Shuo Xu, Shaorong Yan, Jun You, Xiaochen Wu. (2024) Antibacterial Micelles-Loaded Carboxymethyl Chitosan/Oxidized Konjac Glucomannan Composite Hydrogels for Enhanced Wound Repairing. ACS Applied Materials & Interfaces, [PMID:38449378] [10.1021/acsami.3c19268] |
| 24. Yilin Li, Yali Song, Na Gan, Lijuan Chen, Si Chen, Yi He, Tingting Zeng, Xinhui Wang, Wei Wang, Di Wu. (2024) Gliadin/Konjac glucomannan particle-stabilized Pickering emulsion for honokiol encapsulation with enhanced digestion benefits. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39710026] [10.1016/j.ijbiomac.2024.139064] |
| 25. Miao Lurong, Yuan Ziqi, Zhang Shijia, Zhang Guangqin. (2024) Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice. INFLAMMOPHARMACOLOGY, [PMID:38829504] [10.1007/s10787-024-01498-9] |
| 26. Qiang Zhou, Meiyu Chang, Shuhan Guo, Yiming Zhang, Qiufang Qu, Qingnan Zhou, Zhiheng Li, Sanqiao Yao. (2024) Honokiol ameliorates silica-induced lung fibrosis by inhibiting macrophage pyroptosis via modulating cGAS/STING signaling. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:39681061] [10.1016/j.intimp.2024.113812] |
| 27. Weijuan Zou, Feng Gao, Zheying Meng, Xiaojun Cai, Wu Chen, Yuanyi Zheng, Tao Ying, Longchen Wang, Jianrong Wu. (2024) Lactic acid responsive sequential production of hydrogen peroxide and consumption of glutathione for enhanced ferroptosis tumor therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:38442520] [10.1016/j.jcis.2024.03.001] |
| 28. Fei Yang, Bin Yang, Kaige Song, Yingjie Jin, Gaoxue Wang, Pengfei Li, Qing Yu, Fei Ling. (2024) Natural product honokiol exhibits antiviral effects against Micropterus salmoides rhabdovirus (MSRV) both in vitro and in vivo. JOURNAL OF FISH DISEASES, 47 (4): (e13915). [PMID:38191774] [10.1111/jfd.13915] |
| 29. Guoyu Wei, Wei Zhao, Huayang Xu, Guangming Wang, Hualei Wang, Anlong Hu. (2024) Phytochemicals demonstrate potential fungicidal activity against Fusarium commune, a newly identified pathogenic fungus causing rhizome rot in Polygonatum cyrtonema (giant Chinese Solomon's seal). JOURNAL OF PHYTOPATHOLOGY, 172 (2): (e13301). [PMID:] [10.1111/jph.13301] |
| 30. Chang Liu, Zhengjiang Cao, Li Li, Qingyin Li, Chunle Zhang, Yunbing Wang, Linhua Li, Ping Fu. (2024) Self-Assembled Pt/Honokiol Nanomicelles for the Treatment of Sepsis-Associated Acute Kidney Injury. ACS Biomaterials Science & Engineering, [PMID:39681978] [10.1021/acsbiomaterials.4c01852] |
| 31. Ruige Yang, Xiangjing Fu, Jiangping Fan, Tingting Wang, Jian Song, Ting Xu, Yong Guo, Sai-Yang Zhang. (2024) Semisynthesis and biological evaluation of novel honokiol thioethers against colon cancer cells HCT116 via inhibiting the transcription and expression of YAP protein. BIOORGANIC & MEDICINAL CHEMISTRY, [PMID:38759254] [10.1016/j.bmc.2024.117762] |
| 32. Zhen Qin, Qiang-qiang Chu, An-lan Ding, Chuan-Ying Li, Mao-yan Zhang. (2024) Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, [PMID:38799140] [10.3164/jcbn.23-42] |
| 33. Zhen Lin, Ruyu Cao, Fan Nie, Lingling Ma, Jing Xu, Yuanqiang Guo. (2025) Synergistic chemoimmunotherapy in a green framework: pH-responsive natural plant polysaccharide-based nanoparticles. Biomaterials Advances, [PMID:40184782] [10.1016/j.bioadv.2025.214294] |
| 34. Xinkang Li, Zirui Chen, Lijun Tang, Jingjing Guo, Baoqiong Li. (2024) The Application of Multilinear Regression Model for Quantitative Analysis on the Basis of Excitation-Emission Matrix Spectra and the Release of a Free Graphical User Interface. Symmetry-Basel, 16 (7): (922). [PMID:] [10.3390/sym16070922] |
| 35. Yuhan Liu, Yu Lei, Luorui Shang, Zhaomin Yu, Li Wang, Jiabin Zhou, Guangtao Pan. (2025) Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40840728] [10.1016/j.jep.2025.120450] |
| 36. Shiqi Li, Lingzhen Lin, Yuanwu Zhong, Jiaxin Zhao, Kan Jing, Tao Nie. (2025) Multifunctional composite hydrogel with natural polymer silk fibroin and gelatin for promoting chronic wound healing. Journal of Materials Chemistry B, [PMID:41384783] [10.1039/D5TB02034D] |
| 37. Yang Lin, Zhengmeng Jiang, Zhilu Yu, Tianqing Huang, Wanyu Gui, Ziyuan Wang, Fei Li, Pingting Xiao, Changyin Li, Ehu Liu. (2026) Honokiol attenuates diabetes by enriching Akkermansia muciniphila andregulating tryptophan metabolism in mice. Chinese Journal of Natural Medicines, 24 (1): (59-72). [PMID:41571367] [10.1016/S1875-5364(26)61077-1] |
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