Idebenone - 10mM in DMSO , Antioxidant and mitochondrial electron carrier, CAS No.58186-27-9, Antioxidant and mitochondrial electron carrier

CAS: 58186-27-9 Cat. No.: I408849 Peso molecular: 338.44 Número EC: 814-253-7

GRADE & PURITY 10mM in DMSO

Synonyms

CV-2619 | 2-​(10-​hydroxydecyl)​-​5,​6-​dimethoxy-​3-​methyl-2,​5-​cyclohexadiene-​1,​4-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
In vitro

Idebenone effectively protects from retinal cell injury after oxidative stress or hypoglycemia, whereas the protection afforded after postincubation of both antioxidants is decreased. Idebenone attenuates delayed retinal cell damage, mediated by chemical ischemia. Idebenone, a centrally active antioxidant used to treat multiinfarct dementia, protects cells from this form of glutamate-induced cytotoxicity in vitro. Idebenone provides significant protection against the neuronal degeneration induced by intrastriatal injection of kainic acid and quisqualic acid, but not the NMDA receptor agonist, quinolinic acid.

In vivo

Idebenone prevents the behavioural deficits in Y-maze and water maze, but not passive avoidance, tasks in A beta-(1-42)-infused rats when they are repeatedly administered by mouth once a day from 3 days before the start of A beta infusion to the end of behavioural experiments. Idebenone (100 and 300 mg/kg) is orally administered to rats for 3 days, it increases the state 3 respiration stimulated by ADP, slightly decreasez the state 4 respiration after the consumption of ADP and resultz in a significant increase of the respiratory control index (RCI) by 14-19% for glutamate oxidation and 10-17% for succinate oxidation, respectively. Idebenone significantly suppresses by about 10% the non-respiratory oxygen consumption, which closely associated with non-enzymatic reactions such as lipid peroxidation, membrane lysis and swelling of mitochondria.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

CV-2619 | 2-​(10-​hydroxydecyl)​-​5, ​6-​dimethoxy-​3-​methyl-2, ​5-​cyclohexadiene-​1, ​4-​dione

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Mecanismo de acción

Antioxidant and mitochondrial electron carrier

Propiedades del producto

• ALogP: 4.3

Nombres e identificadores

• Isómeros SMILES: CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO
• RTECS: GU5290000
• Peso molecular: 338.44
• Reaxy-Rn: 2001459
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2001459&ln=

Objetivos asociados (humanos)

CYP2C19 Tchem Cytochrome P450 2C19 (1 Activities)

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 53℃

Referencias

1. Zhiwen Li, Zhilin Zhou, Jianghua Wang, Tingxian Tao, Yingqiang Fu.  (2023)  Aggregation-induced emission enhancement N, S-CQDs for selective detection of CIP in the environment.  NANOTECHNOLOGY,  34  (39): (395503).  [PMID:37343538] [10.1088/1361-6528/ace05a]

2. Xiao Tu, Jiaxin Hu, Jinghao Peng, Qihan Chen, Yangle Zhao, Zemao Gu.  (2025)  Discovery of thymoquinone analogues with high anthelmintic activity against monogenean infections in goldfish (Carassius auratus).  VETERINARY PARASITOLOGY,      [PMID:39837239] [10.1016/j.vetpar.2025.110401]

3. Lei Shu, Peili Luo, Chuanyu Ren, Ziwei Lai, Xuejuan Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang.  (2025)  Inhalable Fibroin Hybrid Liposomes for the Targeted Treatment of Lung Adenocarcinoma via Autophagy-Enhanced Ferroptosis.  ACS Nano,      [PMID:40878028] [10.1021/acsnano.5c09493]

4. Haiyan Zhu, Yijing Yang, Yenan Duan, Xin Zheng, Zixiong Lin, Jie Zhou.  (2024)  Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39033970] [10.1016/j.abb.2024.110100]