Ilomastat (GM6001, Galardin) - Moligand™, 10mM in DMSO , Inhibitor of ADAM10;Inhibitor of ADAM12;Inhibitor of ADAM17;Inhibitor of ADAM9;Inhibitor of MMP1;Inhibitor of MMP12;Inhibitor of MMP13;Inhibitor of MMP14;Inhibitor of MMP15;Inhibitor of MMP16;Inhibi, Inhibitor of ADAM10;Inhibitor of ADAM12;Inhibitor of ADAM17;Inhibitor of ADAM9;Inhibitor of MMP1;Inhibitor of MMP12;Inhibitor of MMP13;Inhibitor of MMP14;Inhibitor of MMP15;Inhibitor of MMP16;Inhibitor of MMP17;Inhibitor of MMP2;Inhibitor of MMP26;Inhibit

CAS: 142880-36-2 Cat. No.: I408289 Peso molecular: 388.5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Ilomastat (GM6001, Galardin) Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with K i of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6
In vitro

GM6001 inhibits human skin fibroblast collagenase with K_i of 0.4 nM when assayed with a synthetic thio ester substrate at pH 6.5, with 50-fold selectivity over two bacterial enzymes, thermolysin and Pseudomonas aeruginosa elastase. GM 6001 (0.1 nM - 10 nM) inhibits gelatinase A and gelatinase B produced by T-cells, thus inhibits T-cell homing.

In vivo

Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with K_i of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM,

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of ADAM10;Inhibitor of ADAM12;Inhibitor of ADAM17;Inhibitor of ADAM9;Inhibitor of MMP1;Inhibitor of MMP12;Inhibitor of MMP13;Inhibitor of MMP14;Inhibitor of MMP15;Inhibitor of MMP16;Inhibitor of MMP17;Inhibitor of MMP2;Inhibitor of MMP26;Inhibit

Nombres e identificadores

• Isómeros SMILES: CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC
• Peso molecular: 388.5
• Reaxy-Rn: 24712769
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24712769&ln=

Objetivos asociados (humanos)

MMP1 Tchem Interstitial collagenase (13 Activities)

Discover Target: MMP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP7 Tchem Matrilysin (1 Activities)

Discover Target: MMP7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP17 Tchem Matrix metalloproteinase-17 (2 Activities)

Discover Target: MMP17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP13 Tchem Collagenase 3 (2 Activities)

Discover Target: MMP13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP14 Tchem Matrix metalloproteinase-14 (9 Activities)

Discover Target: MMP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 (13 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP12 Tchem Macrophage metalloelastase (9 Activities)

Discover Target: MMP12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP15 Tchem Matrix metalloproteinase-15 (3 Activities)

Discover Target: MMP15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP26 Tchem Matrix metalloproteinase-26 (3 Activities)

Discover Target: MMP26

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (14 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP16 Tchem Matrix metalloproteinase-16 (3 Activities)

Discover Target: MMP16

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAMTS4 Tchem A disintegrin and metalloproteinase with thrombospondin motifs 4 (1 Activities)

Discover Target: ADAMTS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAMTS5 Tchem A disintegrin and metalloproteinase with thrombospondin motifs 5 (1 Activities)

Discover Target: ADAMTS5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAM17 Tchem Disintegrin and metalloproteinase domain-containing protein 17 (3 Activities)

Discover Target: ADAM17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAM10 Tchem Disintegrin and metalloproteinase domain-containing protein 10 (3 Activities)

Discover Target: ADAM10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAM12 Tchem Disintegrin and metalloproteinase domain-containing protein 12 (2 Activities)

Discover Target: ADAM12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADAM9 Tchem Disintegrin and metalloproteinase domain-containing protein 9 (3 Activities)

Discover Target: ADAM9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP3 Tchem Stromelysin-1 (10 Activities)

Discover Target: MMP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP8 Tchem Neutrophil collagenase (2 Activities)

Discover Target: MMP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL (102.35 mM)

Referencias

1. Ding Qiu, Shuishen Zhang, Chanyan Huang, Xinying Wang, Jianping Deng, Haiyang Sun, Bingbing Feng, Ying Tan, Kaile Ji, Shaoting Xu, Xiaoqi Ye, Chao Cheng, Shigeru Kakuta, Yoshiyuki Adachi, Yoichiro Iwakura, Shuai Wang, Shaowei Dong, Ce Tang.  (2025)  Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis.  IMMUNITY,  58  (7): (1811-1829).  [PMID:40494347] [10.1016/j.immuni.2025.05.007]

2. Wenyan Zhao, Xin Zhou, Xingli Zhao, Hao Tian, Yang Su, Shanlan Zhao, Min Liu, Qiao Zhang, Lin Chen, Xiaochen Li, Di Liu, Junxuan Li, Lang Li, Yanhong Wang, Xingtong Li, Jin Yan, Wen Chen, Bing Liu, Chuhong Zhu, Wen Zeng.  (2026)  CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2+ endothelial cells.  Cell Reports Medicine,      [PMID:41887221] [10.1016/j.xcrm.2026.102698]