IMP-1088 - ≥98% , CAS No.2059148-82-0

CAS: 2059148-82-0 Cat. No.: I647608 Peso molecular: 453.53 PubChem CID: 132274735

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC 50 s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a K d of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection

In Vitro

IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC 50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC 50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection. IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples. IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h. IMP-1088 (0.24 nM-1 µM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h. IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Liquid

IC50& Target:IC50: <1 nM (HsNMT1) and <1 nM (HsNMT2), Kd: <210 pM (HsNMT1)

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC 50 s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a K d of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Isómeros SMILES: CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C
• PubChem CID: 132274735
• Peso molecular: 453.53

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 100 mg/mL (220.49 mM; Need ultrasonic)
• Peso molecular: 453.500 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 453.234 Da
• Monoisotopic Mass: 453.234 Da
• Topological Polar Surface Area: 48.100 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 642.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1