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γ-secretasa

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  1. RO4929097, Gamma-secretase inhibitor
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    RO4929097, Gamma-secretase inhibitor
    CAS: 847925-91-1 PubChem CID: 49867930 Formula: C22H20F5N3O3 Peso molecular: 469.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    En Stock Articulo #: R127403
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    Identificadores técnicos
    Nombre IUPAC
    2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
    SMILES
    CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
    InChIKey
    OJPLJFIFUQPSJR-INIZCTEOSA-N
    InChI
    1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,2show more
    Sinónimos
    NCGC00263162-01 | Propanediamide, N-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pen...
  2. NNC 26-9100 - Moligand™, ≥99%(HPLC) CAS No(199522-35-5) by Aladdin Scientific
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    NNC 26-9100, Agonist of SST 4 receptor
    CAS: 199522-35-5 Formula: C22H25N6Cl2SBr Peso molecular: 556.35
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC)
    En Stock Articulo #: N287784
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    Nombre IUPAC
    1-[3-[(5-bromopyridin-2-yl)-[(3,4-dichlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea
    SMILES
    C1=CC(=C(C=C1CN(CCCNC(=S)NCCCC2=CN=CN2)C3=NC=C(C=C3)Br)Cl)Cl
    InChIKey
    UREJDUPKGMFJRU-UHFFFAOYSA-N
    InChI
    1S/C22H25BrCl2N6S/c23-17-5-7-21(29-12-17)31(14-16-4-6-19(24)20(25)11-16)10-2-9-28-22(32)27-8-1-3-18-13-26-15-30-18/h4-7,11-13,15H,1-3,8-10,14H2,(H,26,show more
    Sinónimos
    1-(3-(n-(5-bromopyridin-2-yl)-n-(3,4-dichlorobenzyl)amino)propyl)-3-(3-(1h-imidazol-4-yl)propyl)thiourea | AKOS027470...
  3. MRK 560
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    MRK 560
    CAS: 677772-84-8 Número EC: 112-628-3 Formula: C19H17ClF5NO4S3 Peso molecular: 517.92
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC)
    En Stock Articulo #: M287545
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    Nombre IUPAC
    N-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
    SMILES
    C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
    InChIKey
    WDZVWDXOIGQJIO-UHFFFAOYSA-N
    InChI
    1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2
    Sinónimos
    N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide | N-((1s,4s)-...
  4. PF-3084014, Gamma-secretase inhibitor
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    PF-3084014, Gamma-secretase inhibitor
    CAS: 1290543-63-3 Formula: C27H41F2N5O Peso molecular: 489.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    En Stock Articulo #: P127448
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    Nombre IUPAC
    (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
    SMILES
    CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F
    InChIKey
    VFCRKLWBYMDAED-REWPJTCUSA-N
    InChI
    1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-1show more
    Sinónimos
    NCGC00091375-02 | A11993 | A910640 | EX-A855 | PF3084014 | PF-3084014 | (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydrona...
  5. LY-411575
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    LY-411575
    CAS: 209984-57-6 Formula: C26H23F2N3O4 Peso molecular: 479.48
    ≥98%
    En Stock Articulo #: L125846
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    Identificadores técnicos
    Nombre IUPAC
    (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
    SMILES
    CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
    InChIKey
    ULSSJYNJIZWPSB-CVRXJBIPSA-N
    InChI
    1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,show more
    Sinónimos
    AC-32717 | LY 411,575 | N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibe...
  6. YO-01027 - ≥97%, used for , CAS No. 209984-56-5, by Aladdin Scientific
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    YO-01027
    CAS: 209984-56-5 PubChem CID: 11454028 Formula: C26H23F2N3O3 Peso molecular: 463.48
    ≥97%
    En Stock Articulo #: Y129283
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    Precios y tamaños del paquete
    Identificadores técnicos
    Nombre IUPAC
    (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
    SMILES
    CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F
    InChIKey
    QSHGISMANBKLQL-OWJWWREXSA-N
    InChI
    1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(show more
    Sinónimos
    Dibenzazepine (Deshydroxy LY 411575) | NCGC00263188-03 | SB47619 | SCHEMBL3046688 | C26H23F2N3O3 | SW219340-1 | EX-A0...
  7. DAPT
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    DAPT
    CAS: 208255-80-5 Formula: C23H26F2N2O4 Peso molecular: 432.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    En Stock Articulo #: D126677
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    Identificadores técnicos
    Nombre IUPAC
    tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
    SMILES
    CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
    InChIKey
    DWJXYEABWRJFSP-XOBRGWDASA-N
    InChI
    1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,2show more
    Sinónimos
    Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)- | MRF-0000012 | (S)-tert...
  8. MK-0752
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    MK-0752
    CAS: 471905-41-6 Formula: C21H21ClF2O4S Peso molecular: 442.91
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    En Stock Articulo #: M126008
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    Identificadores técnicos
    Nombre IUPAC
    3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
    SMILES
    C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
    InChIKey
    XCGJIFAKUZNNOR-UHFFFAOYSA-N
    InChI
    1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
    Sinónimos
    3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic Acid | 5-O-Demethyltangeretin | SCHEMBL18288...
  9. Avagacestat, Gamma-secretase inhibitor
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    Avagacestat, Gamma-secretase inhibitor
    CAS: 1146699-66-2 Formula: C20H17ClF4N4O4S Peso molecular: 520.89
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    En Stock Articulo #: B126453
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    Identificadores técnicos
    Nombre IUPAC
    (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
    SMILES
    C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl
    InChIKey
    XEAOPVUAMONVLA-QGZVFWFLSA-N
    InChI
    1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,2show more
    Sinónimos
    DB11893 | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropen...
  10. E 2012
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    E 2012
    CAS: 870843-42-8 Formula: C25H26FN3O2 Peso molecular: 419.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    En Stock Articulo #: E288274
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    Identificadores técnicos
    Nombre IUPAC
    (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one
    SMILES
    CC1=CN(C=N1)C2=C(C=C(C=C2)C=C3CCCN(C3=O)C(C)C4=CC=C(C=C4)F)OC
    InChIKey
    PUOAETJYKQITMO-LANLRWRYSA-N
    InChI
    1S/C25H26FN3O2/c1-17-15-28(16-27-17)23-11-6-19(14-24(23)31-3)13-21-5-4-12-29(25(21)30)18(2)20-7-9-22(26)10-8-20/h6-11,13-16,18H,4-5,12H2,1-3H3/b21-13+show more
    Sinónimos
    (3e)-1-[(1s)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]methylene]-2-piperidinone | F...
  11. Sulindac Sulfide
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    Sulindac Sulfide
    CAS: 32004-67-4 PubChem CID: 6034911 Formula: C20H17FO2S Peso molecular: 340.41
    ≥98%
    En Stock Articulo #: S160989
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    Nombre IUPAC
    2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]acetic acid
    SMILES
    CC1=C(C2=C(C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O
    InChIKey
    LFWHFZJPXXOYNR-RQZCQDPDSA-N
    InChI
    1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+
    Sinónimos
    (E/Z)-Sulindac sulfide | J-018597 | {5-Fluoro-2-methyl-1-[4-(methylsulphanyl)benzylidene]-1H-inden-3-yl}acetic acid |...
  12. L-685,458
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    L-685,458
    CAS: 292632-98-5 Formula: C39H52N4O6 Peso molecular: 672.85
    ≥98%
    En Stock Articulo #: L275059
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    Identificadores técnicos
    Nombre IUPAC
    tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylshow more
    SMILES
    CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O
    InChIKey
    MURCDOXDAHPNRQ-ZJKZPDEISA-N
    InChI
    1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)show more
    Sinónimos
    NCGC00165962-01 | HY-19369 | L 458 | (5S)-[tert-butoxycarbonylamino-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl]-L-Leu-...
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