Lornoxicam - 2mM in DMSO , CAS No.70374-39-9

CAS: 70374-39-9 Cat. No.: L425602 Peso molecular: 371.82 Número EC: 630-354-7

GRADE & PURITY 2mM in DMSO

Synonyms

Lornoxicam|70374-39-9|Chlortenoxicam|Xefocam|Xefo|Lorcam|Lornoxicamum|Ro 13-9297|Lornoxicamum [INN-Latin]|Taigalor|Safem|Telos|Lorcam (TN)|CLTX|Lornoxicam (Xefo)|CCRIS 8589|NSC-759620|Ro-13-9297|6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.
A cyclooxygenase inhibitor.

Specifications

Sinónimos

Lornoxicam | 70374-39-9 | Chlortenoxicam | Xefocam | Xefo | Lorcam | Lornoxicamum | Ro 13-9297 | Lornoxicamum [INN-Latin] | Taigalor | Safem | Telos | Lorcam (TN) | CLTX | Lornoxicam (Xefo) | CCRIS 8589 | NSC-759620 | Ro-13-9297 | 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2, 3-e

Especificaciones y pureza

2mM in DMSO

Mecanismos bioquímicos y fisiológicos

Lornoxicam is a cyclooxygenase inhibitor. Structurally similar to Tenoxicam. An anti-inflammatory and an analgesic. Lornoxicam is an inhibitor of Cox-1 and Cox-2.Potent COX-1 and COX-2 inhibitor (IC 50 = 5 and 8 nM for COX-1 and COX-2, respectively). Inhi

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Sonrisas canónicas: CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
• IUPAC Name: 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
• InChIKey: WLHQHAUOOXYABV-UHFFFAOYSA-N
• INCHI: 1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
• Isómeros SMILES: CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
• WGK Alemania: 3
• RTECS: XJ9095000
• Peso molecular: 371.82
• Reaxy-Rn: 1039965
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1039965&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Alpha amino acids and derivatives
• Alternative Parents: Thienothiazines 2,3,5-trisubstituted thiophenes N-arylamides 1,2-thiazines Aryl chlorides Imidolactams Organosulfonamides Pyridines and derivatives Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-amino acid or derivatives - Thienothiazine - N-arylamide - 2,3,5-trisubstituted thiophene - Ortho-thiazine - Aryl chloride - Aryl halide - Organosulfonic acid amide - Pyridine - Imidolactam - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Vinylogous acid - Thiophene - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
• External Descriptors: monocarboxylic acid amide - organochlorine compound - pyridines - heteroaryl hydroxy compound - thienothiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: Heat sensitive
• Punto de fusión (°C): 230°C
• Peso molecular: 371.800 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 370.98 Da
• Monoisotopic Mass: 370.98 Da
• Topological Polar Surface Area: 136.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 634.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Junjing Li, Xu Liu, Zilin Tan, Liang Wang.  (2025)  Performance and mechanism of palladium-based binary nanowires for electrocatalytic removal of halogenated PPCPs.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2025.106188]

2. Wei Shao, Xiuling Liu, Zhaojing Jing, Ziyang Guo, Xiaowen Huo, Weihao Zhang, Haitao Wang, Na Chang.  (2026)  Ionic interactions drive SC[4]A to regulate polyamide networks for achieving high-efficiency Li+/Mg2+ separation.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2026.137014]