≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
MC Gly Gly Phe Gly GABA Exatecan ADC is a drug linker conjugate containing the topoisomerase Exatecan with an IC50 of 22 μ M. MC Gly Gly Phe Gly GABA Hexatecan targets multiple antibodies and exhibits cytotoxicity and anti-tumor efficacy in vitro and in vivo.
In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
In vitro studies: MC Gly Gly Phe Gly GABA Hexatecan (0-10 μ M) exhibits cytotoxicity in SR (CD30 positive), HL60 (CD33 positive), U251 (CD70 positive), and Calu-6 (B7-H3 positive) cells by targeting CD30, CD33, CD70, and B7-H3 antibodies. In vivo studies: MC Gly Gly Phe Gly GABA Hexatecan (10 mg/kg, intravenous injection, once a week for 2 weeks) showed anti-tumor activity in A375 xenograft mice.
Specifications
Especificaciones y pureza
≥99%
Mecanismos bioquímicos y fisiológicos
MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Pureza
≥99%
Nombres e identificadores
Peso molecular
1032.08
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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