Meloxicam - Moligand™, ≥98% , Inhibitor of COX-1;Inhibitor of COX-2, CAS No.71125-38-7, Inhibitor of COX-1;Inhibitor of COX-2

CAS: 71125-38-7 Cat. No.: M129228 Peso molecular: 351.4 Número EC: 615-253-8

GRADE & PURITY Moligand™, ≥98%

Synonyms

UH-AC 62XX | Meloxicam (JAN/USP/INN) | Meloxoral | MLS006011422 | QMIIZ ODT | AMOXICILLIN CRYSTALLINE | C14H13N3O4S2 | MELOXICAM [EP MONOGRAPH] | Meloxicam Solution for Injection | VG2QF83CGL | Vivlodex | BIDD:GT0726 | Emdocam | Movatec | Parocin | Metaca

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

El meloxicam (Mobic) es un agente antiinflamatorio no esteroideo con efectos analgésicos y febrífugos.
Es un inhibidor de Cox-1 y Cox-2, selectivo para Cox-2.

Specifications

Sinónimos

UH-AC 62XX | Meloxicam (JAN/USP/INN) | Meloxoral | MLS006011422 | QMIIZ ODT | AMOXICILLIN CRYSTALLINE | C14H13N3O4S2 | MELOXICAM [EP MONOGRAPH] | Meloxicam Solution for Injection | VG2QF83CGL | Vivlodex | BIDD:GT0726 | Emdocam | Movatec | Parocin | Metaca

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Se ha informado de que el meloxicam, un agente antiinflamatorio no esteroideo, inhibe la isoforma inducible de Cox-2. El meloxicam es un inhibidor selectivo de la Cox-2 (IC50 de 4, 7 μM) frente a la Cox-1 (IC50 de 36, 6 μM). Los estudios sugieren que el mel

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of COX-1;Inhibitor of COX-2

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. Tóxico, consulte la SDS para más información ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504771345
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504771345
• Sonrisas canónicas: CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
• IUPAC Name: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide
• InChIKey: ZRVUJXDFFKFLMG-UHFFFAOYSA-N
• INCHI: 1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
• Isómeros SMILES: CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
• RTECS: DL0702000
• Número ONU: 2811
• Grupo de embalaje: III
• Peso molecular: 351.4
• Reaxy-Rn: 5886369
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5886369&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzothiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzothiazines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzothiazines
• Alternative Parents: Alpha amino acids and derivatives N-arylamides 2,5-disubstituted thiazoles Organosulfonamides Benzenoids 1,2-thiazines Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-amino acid or derivatives - Benzothiazine - N-arylamide - 2,5-disubstituted 1,3-thiazole - Ortho-thiazine - Benzenoid - Organosulfonic acid amide - Azole - Heteroaromatic compound - Vinylogous acid - Thiazole - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzothiazines. These are organic compounds containing a benzene fused to a thiazine ring (a six-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).
• External Descriptors: monocarboxylic acid amide - 1,3-thiazole - benzothiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (6 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: H2O: 0.67 mg/mL (1.91 mM; ultrasound assisted dissolution); DMSO: 25 mg/mL (71.14 mM; ultrasound assisted dissolution (<60 ° C); Ethanol:<1 mg/mL
• Sensibilidad: Heat sensitive
• Punto de fusión (°C): 255°C
• Peso molecular: 351.400 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 351.035 Da
• Monoisotopic Mass: 351.035 Da
• Topological Polar Surface Area: 136.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 628.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen.  (2023)  A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:37806085] [10.1016/j.biopha.2023.115641]

2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang.  (2023)  An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices.  ANALYST,  148  (18): (4339-4345).  [PMID:37580992] [10.1039/D3AN01211E]

3. Meizhu Qin, Xinping Hu, Jingyan Guo.  (2023)  Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene.  Coatings,  13  (4): (733).  [PMID:] [10.3390/coatings13040733]

4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong.  (2023)  Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials.  JOURNAL OF SEPARATION SCIENCE,  46  (6): (202200862).  [PMID:36680331] [10.1002/jssc.202200862]

5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu.  (2022)  UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice.  Microbiology Spectrum,      [PMID:36453911] [10.1128/spectrum.03424-22]

6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu.  (2022)  Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans.  Pharmaceutics,  14  (9): (1937).  [PMID:36145681] [10.3390/pharmaceutics14091937]

7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu.  (2022)  Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture.  Materials Today Energy,      [PMID:] [10.1016/j.mtener.2022.101010]

8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang.  (2022)  Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.128400]

9. Xiaoqiang Feng, Zhengyi He, Lingyan Yu, Zhiduo Liu, Gang Wang, Siwei Yang, Guqiao Ding.  (2021)  Dual-enhanced Raman scattering sensors incorporating graphene plasmonic nanoresonators.  Journal of Materials Chemistry C,  9  (37): (12768-12777).  [PMID:] [10.1039/D1TC02461B]

10. Wei Zhu, Xiaoqiang Feng, Zhiduo Liu, Menghan Zhao, Peng He, Siwei Yang, Shiwei Tang, Da Chen, Qinglei Guo, Gang Wang, Guqiao Ding.  (2021)  Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid.  ACS Applied Materials & Interfaces,      [PMID:33957757] [10.1021/acsami.1c02182]

11. Ru Zhou, Jingjing Mu, Xiaoyan Sun, Yanming Ding, Juncheng Jiang.  (2020)  Application of intumescent flame retardant containing aluminum diethyphosphinate, neopentyl glycol, and melamine for polyethylene.  SAFETY SCIENCE,      [PMID:] [10.1016/j.ssci.2020.104849]

12. Chen Xiao, Xi Zhiyu, Liang Huaibin, Sun Yuhao, Zhong Zhihong, Wang Baofeng, Bian Liuguan, Sun Qingfang.  (2019)  Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro.  Frontiers in Neuroscience,      [PMID:31404262] [10.3389/fnins.2019.00760]

13. Tong Wang, Hai-Long Wu, Yong-Jie Yu, Wan-Jun Long, Li Cheng, An-Qi Chen, Ru-Qin Yu.  (2019)  A simple method for direct modeling of second-order liquid chromatographic data with retention time shifts and holding the second-order advantage.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31326090] [10.1016/j.chroma.2019.07.014]

14. Shouwu Yu, Shujuan Xiao, Zewen Zhao, Xiaowen Huo, Junfu Wei.  (2019)  Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1016/j.cjche.2019.04.023]

15. Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang.  (2016)  Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection.  Drug Design Development and Therapy,      [PMID:27895468] [10.2147/DDDT.S118145]

16. Wang Yu, Gao Lei, Qin Dongli, Chen Ligang.  (2016)  Analysis of Melamine in Milk Powder by CNT-MIP with Matrix Solid Phase Dispersion and LC-MS/MS.  Food Analytical Methods,  10  (5): (1386-1396).  [PMID:] [10.1007/s12161-016-0705-1]

17. Kim Han Sol, Cho Ha Ra, Ho Myoung Jin, Kang Myung Joo, Choi Yong Seok.  (2016)  Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS.  ARCHIVES OF PHARMACAL RESEARCH,  39  (12): (1653-1662).  [PMID:27752829] [10.1007/s12272-016-0845-2]

18. Rongli Zhang, Sheng Xu, Ye Zhu, Wei Zhao, Jing Luo, Xiaoya Liu, Dingxing Tang.  (2016)  Molecularly imprinted nanohybrids based on dopamine-modified poly(γ-glutamic acid) for electrochemical sensing of melamine.  BIOSENSORS & BIOELECTRONICS,      [PMID:27196255] [10.1016/j.bios.2016.05.030]

19. Xu Xiuzhu, Chen Shuixia, Zhuang Linzhou, Zheng Chunhao, Wu Yingzhu.  (2014)  Establishment of a novel surface-imprinting system for melamine recognition and mechanism of template–matrix interactions.  JOURNAL OF MATERIALS SCIENCE,  49  (7): (2853-2863).  [PMID:] [10.1007/s10853-013-7991-4]

20. Peipei Cheng, Xinting Wang, Qian Liu, Tianshu Yang, Enrui Dai, Wanjing Sha, Huiyan Qu, Hua Zhou.  (2024)  LuQi Formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart  failure..  PHYTOMEDICINE,      [PMID:38295662] [10.1016/j.phymed.2024.155357]

21. Wenyuan Li, Lin Chen, Minpeng Li, Kaiye Peng, Xuemei Lin, Yifan Feng, Yun Zou, Xia Wu.  (2025)  Study on chemical composition, anti-inflammatory activity and quality control of the branch bark of Morus alba L..  FITOTERAPIA,      [PMID:39826618] [10.1016/j.fitote.2025.106383]

22. Minghao Zuo, Heng Zhang, Jialu Lv, Yanyan Zhou, Zhijian Xie, Yiqun Zhou.  (2025)  A Novel Micro/Nano-Roughened Self-Glazed Zirconia Implant With Enhanced Osseointegration and Satisfactory Soft Tissue Sealing: An In Vitro and In Vivo Study.  CLINICAL ORAL IMPLANTS RESEARCH,      [PMID:40851380] [10.1111/clr.70021]

23. Yanchao Li, Haosen Zhang, Tianwei Zhang, Tao Liu.  (2023)  Study of drying processes combined with homogenization to produce amorphous nanoparticles.  DRYING TECHNOLOGY,      [PMID:] [10.1080/07373937.2023.2272738]

24. Zhao Haitao, Bian Guoqing, Xu Xiang, He Weiwei, Zhang Lifen, Cheng Zhenping.  (2023)  Persistent radical anion of perylene dianhydride: an emerging metal-free photocatalyst for near-infrared photocontrolled RAFT polymerization.  Science China-Chemistry,      [PMID:] [10.1007/s11426-023-1733-0]

25. Xu Xiang-Ying, Xiao Yue, Liu Xu, Huang Yue, Ji Ying, Ji Yawei, Gao Yuan, Liu Su, Yang Jian-Jun, Cao Jun-Li, Zhou Chunyi, Xiao Cheng.  (2025)  A ventral pallidum-locus coeruleus-lateral hypothalamus pathway modulates brain arousal in freely behaving and isoflurane-anesthetized male mice.  Nature Communications,  16  (1): (1-18).  [PMID:40379709] [10.1038/s41467-025-59857-1]