Meloxicam - Moligand™, ≥98% , Inhibitor of COX-1;Inhibitor of COX-2, CAS No.71125-38-7, Inhibitor of COX-1;Inhibitor of COX-2

CAS: 71125-38-7 Cat. No.: M129228 Fórmula: C₁₄H₁₃N₃O₄S₂ Peso molecular: 351.4 Número EC: 615-253-8

GRADE & PURITY Moligand™, ≥98%

Synonyms

UH-AC 62XX | Meloxicam (JAN/USP/INN) | Meloxoral | MLS006011422 | QMIIZ ODT | AMOXICILLIN CRYSTALLINE | C14H13N3O4S2 | MELOXICAM [EP MONOGRAPH] | Meloxicam Solution for Injection | VG2QF83CGL | Vivlodex | BIDD:GT0726 | Emdocam | Movatec | Parocin | Metaca

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

El meloxicam (Mobic) es un agente antiinflamatorio no esteroideo con efectos analgésicos y febrífugos.
Es un inhibidor de Cox-1 y Cox-2, selectivo para Cox-2.

Specifications

Sinónimos

UH-AC 62XX | Meloxicam (JAN/USP/INN) | Meloxoral | MLS006011422 | QMIIZ ODT | AMOXICILLIN CRYSTALLINE | C14H13N3O4S2 | MELOXICAM [EP MONOGRAPH] | Meloxicam Solution for Injection | VG2QF83CGL | Vivlodex | BIDD:GT0726 | Emdocam | Movatec | Parocin | Metaca

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Se ha informado de que el meloxicam, un agente antiinflamatorio no esteroideo, inhibe la isoforma inducible de Cox-2. El meloxicam es un inhibidor selectivo de la Cox-2 (IC50 de 4,7 μM) frente a la Cox-1 (IC50 de 36,6 μM). Los estudios sugieren que el mel

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of COX-1;Inhibitor of COX-2

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. Tóxico, consulte la SDS para más información ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥98%

Nombres e identificadores

Pubchem Sid

504771345

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504771345

Sonrisas canónicas

CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O

IUPAC Name

4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide

InChIKey

ZRVUJXDFFKFLMG-UHFFFAOYSA-N

INCHI

1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

Isómeros SMILES

CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O

RTECS

DL0702000

Número ONU

2811

Grupo de embalaje

III

Peso molecular

351.4

Reaxy-Rn

5886369

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5886369&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzothiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzothiazines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzothiazines
• Alternative Parents: Alpha amino acids and derivatives N-arylamides 2,5-disubstituted thiazoles Organosulfonamides Benzenoids 1,2-thiazines Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-amino acid or derivatives - Benzothiazine - N-arylamide - 2,5-disubstituted 1,3-thiazole - Ortho-thiazine - Benzenoid - Organosulfonic acid amide - Azole - Heteroaromatic compound - Vinylogous acid - Thiazole - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzothiazines. These are organic compounds containing a benzene fused to a thiazine ring (a six-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).
• External Descriptors: monocarboxylic acid amide - 1,3-thiazole - benzothiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (6 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: H2O: 0.67 mg/mL (1.91 mM; ultrasound assisted dissolution); DMSO: 25 mg/mL (71.14 mM; ultrasound assisted dissolution (<60 ° C); Ethanol:<1 mg/mL
• Sensibilidad: Heat sensitive
• Punto de fusión (°C): 255°C
• Peso molecular: 351.400 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 351.035 Da
• Monoisotopic Mass: 351.035 Da
• Topological Polar Surface Area: 136.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 628.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1