Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 21 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic . Minocycline hydrochloride is a hypoxia-inducible factor ( HIF )-1α inhibitor. Minocycline hydrochloride shows anti-cancer , anti-inflammatory , and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
| Isómeros SMILES | CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl |
|---|---|
| WGK Alemania | 3 |
| RTECS | QI7630500 |
| PubChem CID | 54685925 |
| Peso molecular | 493.94 |
| Reaxy-Rn | 4836328 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Rotación específica [α] | -170 to -180 deg(C=0.5、0.1mol/L HCl) |
|---|---|
| Punto de inflamación (°F) | 230°F |
| Punto de inflamación (°C) | >110℃ |
| Punto de ebullición (°C) | 813℃ |
| Punto de fusión (°C) | 205-210℃ |
| 1. Yuehong Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu. (2025) Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments. Materials Today Bio, [PMID:40893356] [10.1016/j.mtbio.2025.102227] |
| 2. Ting Zhu, Yu Yang, Yuhui Shang, Yali Liu, Jinyang Chen. (2025) All-in-one prepared highly stable fluorescent copper nanocluster composite for point-of-care sensing of tetracycline. ANALYTICA CHIMICA ACTA, [PMID:41093536] [10.1016/j.aca.2025.344688] |
| 3. Pei Wang, Lianguo Wang, Yilan Zhan, Yifan Liu, Ziqiang Chen, Jia Xu, Jun Guo, Jun Luo, Junchao Wei, Fei Tong, Zhihua Li. (2023) Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.142293] |
| 4. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi. (2023) Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline. ACS Sensors, [PMID:37862265] [10.1021/acssensors.3c01620] |
| 5. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei. (2023) Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model. International Journal of Nanomedicine, [PMID:37192894] [10.2147/IJN.S402410] |
| 6. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo. (2023) MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization. Small, [PMID:36871144] [10.1002/smll.202207335] |
| 7. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:36244559] [10.1016/j.ijpharm.2022.122285] |
| 8. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang. (2022) Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer. International Journal of Biological Sciences, [PMID:35414768] [10.7150/ijbs.70708] |
| 9. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang. (2022) Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke. PHYTOMEDICINE, [PMID:35276592] [10.1016/j.phymed.2022.154034] |
| 10. Lijuan Yang, Lumin Zeng, Yongqing Tao, Dandan Wang, Kailian Zhang, Meng Tian, Zhining Xia, Die Gao. (2021) Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2021.107089] |
| 11. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu. (2021) Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products. International Journal of Environmental Research and Public Health, 18 (23): (12339). [PMID:34886061] [10.3390/ijerph182312339] |
| 12. Lijuan Yang, Jing Zeng, Tian Quan, Shaochi Liu, Linlin Deng, Xun Kang, Zhining Xia, Die Gao. (2021) Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2021.106391] |
| 13. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji. (2019) Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. BIOMATERIALS, [PMID:31288173] [10.1016/j.biomaterials.2019.119326] |
| 14. Yi Quan, Tan Fang-hui, Tan Jia-an, Chen Xiu-hui, Xiao Qing, Liu Ying-hua, Zhang Gui-ping, Luo Jian-dong. (2019) Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation. ACTA PHARMACOLOGICA SINICA, 40 (8): (1019-1028). [PMID:30792486] [10.1038/s41401-019-0214-z] |
| 15. Yule Wang, Yiran Li, Yue Zhou, Yue Gao, Lu Zhao. (2024) Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization. Drug Design Development and Therapy, [PMID:39308695] [10.2147/DDDT.S479881] |
| 16. Binwang Yang, Zhixiong Ye, Feiyu Lu, Jianna Yu, Jiaxu Liu, Xiuqing Zheng, Cheng Wang, Lian Duan, Zhijian Yang, Guoxing Jing, Wen Liu, Wenshan Li, Wenjie Liu. (2024) High Resolving Power Electrospray Ionization Ion Mobility Spectrometer Based on Fourier Deconvolution Multiplexing. ANALYTICAL CHEMISTRY, [PMID:39413295] [10.1021/acs.analchem.4c04549] |
| 17. Yuwei Zheng, Jiaying Chi, Jiayu Ou, Ling Jiang, Liqing Wang, Rui Luo, Yilang Yan, Zejun Xu, Tingting Peng, Jianfeng Cai, Chuanbin Wu, Peng Teng, Guilan Quan, Chao Lu. (2024) Imidazole-Rich, Four-Armed Host-Defense Peptidomimetics as Promising Narrow-Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections. Advanced Healthcare Materials, [PMID:39039988] [10.1002/adhm.202400664] |
| 18. Hongchao Dai, Lei Yuan, Luyao Fan, Jia Yang, Xinan Jiao. (2024) Occurrence and risk-related features of Bacillus cereus in fluid milk. INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, [PMID:] [10.1111/1471-0307.13054] |
| 19. Xingchen Xu, Pei Wang, Fei Tong, Yifan Liu, Xinyang Hu, Jian Yang, Jun Guo. (2025) Polydopamine-Coated Magnetic Nanoplatform for Magnetically Guided Penetration and Enhanced Antibacterial Efficacy in Root Canal Biofilm Elimination. Polymers, 17 (10): (1305). [PMID:40430601] [10.3390/polym17101305] |
| 20. Xie Min, Cheng Yu, Yang Lizhen, Lin Zijin, Shen Hao, Zhou Xinhua, Liu Zheng, Xing Jieyu, Zhou Sigui, Chen Haiyun. (2025) Tetramethylpyrazine-caffeic Acid Hybrid CT-011 Exerts Dopaminergic Neuroprotection Through Inhibiting Microglia-mediated Neuroinflammation. MOLECULAR NEUROBIOLOGY, 63 (1): (44). [PMID:41239042] [10.1007/s12035-025-05310-9] |
| 21. Yu Cheng, Yao Wen, Zhaohan Wang, Lizhen Yang, Junming Liao, Jieyu Xing, Zheng Liu, Xiaoyan Sheng, Lingli Zhou, Sigui Zhou, Jian Zou, Haiyun Chen. (2026) Anti-Parkinson's disease polysaccharide PFP50-1 attenuated neuroinflammation via inhibition of TLR4/NF-κB and PI3K/Akt pathways and suppression of NLRP3 inflammasome activation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:41616997] [10.1016/j.ijbiomac.2026.150579] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →
