N-Nitroso-N-methylurea - Moligand™, ≥98%, contain Sulfuric acid as stabilizer , CAS No.684-93-5

CAS: 684-93-5 Cat. No.: N136701 Peso molecular: 103.08 Número EC: 211-678-4

GRADE & PURITY Moligand™, ≥98%, contain Sulfuric acid as stabilizer

Synonyms

Methylnitrosourea | 1-Methyl-1-nitrosourea | N-Methyl-N-nitrosourea

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

Methylnitrosourea | 1-Methyl-1-nitrosourea | N-Methyl-N-nitrosourea

Especificaciones y pureza

Moligand™, ≥98%, contain Sulfuric acid as stabilizer

Mecanismos bioquímicos y fisiológicos

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CN(C(=O)N)N=O
• IUPAC Name: 1-methyl-1-nitrosourea
• InChIKey: ZRKWMRDKSOPRRS-UHFFFAOYSA-N
• INCHI: 1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)
• Isómeros SMILES: CN(C(=O)N)N=O
• WGK Alemania: 1
• Número ONU: 2811
• Grupo de embalaje: I
• Peso molecular: 103.08
• Reaxy-Rn: 1756040
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1756040&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Organic carbonic acids and derivatives
      • Subclass Ureas
        • Level5 Nitrosoureas
          • Level6 N-methylnitrosoureas

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Organic carbonic acids and derivatives
• Subclass: Ureas
• Intermediate Tree Nodes: Nitrosoureas
• Direct Parent: N-methylnitrosoureas
• Alternative Parents: Semicarbazides Nitrosamides Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: N-methylnitrosourea - Nitrosamide - Semicarbazide - Organic n-nitroso compound - Organic nitroso compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as n-methylnitrosoureas. These are organonitrogen compounds with the general formula H3CN(N=O)R(N)=O (R = any atom).
• External Descriptors: N-nitrosoureas

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Light & Heat sensitive
• Peso molecular: 103.080 g/mol
• XLogP3: 0.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 103.038 Da
• Monoisotopic Mass: 103.038 Da
• Topological Polar Surface Area: 75.800 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 90.900
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Weiming Yan, Yan Sun, Yutong Wang, Wangjiao Liang, Yuxin Xia, Weihua Yan, Meizhu Chen, Tao Chen, Dongliang Li.  (2023)  The impacts of resveratrol on the retinal degeneration in a rat model of retinitis pigmentosa induced by alkylation: an in-vivo study.  Animal Cells and Systems,      [PMID:37388281] [10.1080/19768354.2023.2226695]

2. Yulin Qi, Lu Liu, Dan Liang, Shiyun Tang, Xiaoyi Yu, Hejiang Ye, Nianzhi Chen.  (2023)  Bujing Yishi tablets alleviate photoreceptor cells death via the P2X7R/CX3CL1/CX3CR1 pathway in Retinitis Pigmentosa rats.  PHYTOMEDICINE,      [PMID:37116386] [10.1016/j.phymed.2023.154828]

3. Han Gaochao, Tan Zhuangsheng, Jing Haiming, Ning Junyu, Li Zinan, Gao Shan, Li Guojun.  (2021)  Comet Assay Evaluation of Lanthanum Nitrate DNA Damage in C57-ras Transgenic Mice.  BIOLOGICAL TRACE ELEMENT RESEARCH,  199  (10): (3728-3736).  [PMID:33403576] [10.1007/s12011-020-02500-5]

4. Liu Ying, Liu Susu, Wu Meiyu, Lv Jianjun, Yang Yanwei, Dan Mo, Liu Lin, Chen Liang, Wu Xiaochun, Fan Changfa, Xu Liming, Xie Liming.  (2020)  In vivo carcinogenicity study of silver nanoparticles in transgenic rasH2 mice by one single-dose intravenous administration.  JOURNAL OF NANOPARTICLE RESEARCH,  22  (6): (1-16).  [PMID:] [10.1007/s11051-020-04836-4]

5. Yan Weiming, Long Pan, Wei Dongyu, Yan Weihua, Zheng Xiangrong, Chen Guocang, Wang Jiancong, Zhang Zuoming, Chen Tao, Chen Meizhu.  (2020)  Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study.  BMC Ophthalmology,  20  (1): (1-10).  [PMID:32070320] [10.1186/s12886-020-1330-8]

6. Man Ren, Hao Zeng, Ping-An Peng, Hui-Ru Li, Cai-Ming Tang, Jian-Fang Hu.  (2017)  Brominated dioxins/furans and hydroxylated polybrominated diphenyl ethers: Occurrences in commercial 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and 2,4,6-tribromophenol, and formation during synthesis of BTBPE.  ENVIRONMENTAL POLLUTION,      [PMID:28413084] [10.1016/j.envpol.2017.03.077]

7. Kangkang Liu, Lining Wang, Jing Peng, Yuanji Lyu, Yiming Li, Dengyi Duan, Wenyi Zhang, Guojiang Wei, Taipeng Li, Yuanjie Niu, Yang Zhao.  (2024)  Drug-Loaded Bacillus Calmette–Guérin Bacteria for Immuno-Chemo Combo Therapy in Bladder Cancer.  ADVANCED MATERIALS,      [PMID:38330363] [10.1002/adma.202310735]

8. Kaili Fu, Alvin Ho Kwan Cheung, Chi Chun Wong, Weixin Liu, Yunfei Zhou, Feixue Wang, Pingmei Huang, Kai Yuan, Olabisi Oluwabukola Coker, Yasi Pan, Danyu Chen, Nga Man Lam, Mengxue Gao, Xiang Zhang, He Huang, Ka Fai To, Joseph Jao Yiu Sung, Jun Yu.  (2024)  Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice.  CELL,      [PMID:38295787] [10.1016/j.cell.2024.01.004]

9. Enjuan Shi, Xiaoqin Wang, Huili Jing, Yayuan Xu, Lei Feng, Fatao He, Dajing Li, Zhuqing Dai.  (2024)  Synergistic effect of chitosan and β-carotene in inhibiting MNU-induced retinitis pigmentosa.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38641272] [10.1016/j.ijbiomac.2024.131671]

10. Tianmin Tang, Shuying Kong, Junyi Xie, Qiurong Deng, Cong Lai, Shuanshuan Guo, Hao Yu, Jianhua Zhou.  (2025)  Prolonged Release of Bacillus Calmette–Guérin by Floating Microbubbles to Enhance Intravesical Immunotherapy for Bladder Cancer.  ACS Nano,      [PMID:40726143] [10.1021/acsnano.5c06540]

11. Langjie Ye, Guanyong Su.  (2025)  Establishment of a sensitive derivatization method for analysis of organophosphate diesters (OPDEs), and their target and nontarget screening in Taihu Lake sediment.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:40763575] [10.1016/j.scitotenv.2025.180173]

12. Yuxin Du, Jingjing Cao, Lumeng Niu, Gao Tan, Jingmin Zhang, Xiaoqian Yi, Yu Li, Jun Wei, Yin Shen.  (2025)  Efficient Derivation of hiPSC-Derived Photoreceptor Precursor Cells and Their Neuroprotective Effects in Retinal Degeneration.  iScience,      [PMID:41467179] [10.1016/j.isci.2025.114196]

13. Madeti Yelizhati, Chong Xiaoyi, Zhang Xiaotian.  (2026)  Construction and application of a genetically engineered mouse model of gastric adenocarcinoma.  Journal of the Chinese Medical Association,      [PMID:41630078] [10.1097/JCMA.0000000000001350]

14. Zihan Mai, Yiyuan Zheng, Jiali Xie, Yi Wen, Shuye Wang, Yuancheng Huang, Haojie Tan, Jingming Chen, Changlong Wang, Yang Tao, Qiuming Chen, Fengbin Liu, Yimin Liang, Xu Chen, Yingpan Zhao, Peiwu Li, Zehong Yang.  (2026)  JianPi QingRe HuoXue Formula targets Cadherin-17 to induce apoptosis in chronic atrophic gastritis with intestinal metaplasia.  PHYTOMEDICINE,      [PMID:41825205] [10.1016/j.phymed.2026.158037]