β-Nicotinamide Mononucleotide(NMN) - ≥99.5% , CAS No.1094-61-7

CAS: 1094-61-7 Cat. No.: N1492501 Peso molecular: 334.22 Beilstein Registry Number: 3570187 Número EC: 214-136-5

GRADE & PURITY ≥99.5%

Synonyms

Nicotinamidemononucleotide | Fosribnicotinamide | β-NM

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

A product of the eNAMPT reaction and a NAD+ intermediate

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.

β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Specifications

Sinónimos

Nicotinamidemononucleotide | Fosribnicotinamide | β-NM

Especificaciones y pureza

≥99.5%

Mecanismos bioquímicos y fisiológicos

Product of the NAMPT reaction and\xa0a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD + ). Ameliorates glucose intolerance by restoring NAD + levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitiv

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥99.5%

Nombres e identificadores

• Sonrisas canónicas: C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
• IUPAC Name: [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
• InChIKey: DAYLJWODMCOQEW-TURQNECASA-N
• INCHI: 1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
• Isómeros SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N
• WGK Alemania: 3
• Peso molecular: 334.22
• Beilstein: 3570187
• Reaxy-Rn: 40276623
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=40276623&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Clase Pyridine nucleotides
      • Subclass Nicotinamide nucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Clase: Pyridine nucleotides
• Subclass: Nicotinamide nucleotides
• Intermediate Tree Nodes: Not available
• Direct Parent: Nicotinamide nucleotides
• Alternative Parents: Pentose phosphates Glycosylamines Monosaccharide phosphates Nicotinamides Alkyl phosphates Pyridinium derivatives Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Primary carboxylic acid amides Secondary alcohols 1,2-diols Azacyclic compounds Oxacyclic compounds Organic zwitterions Organic oxides Hydrocarbon derivatives Organonitrogen compounds Organopnictogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Nicotinamide-nucleotide - Pentose-5-phosphate - Pentose phosphate - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Monosaccharide phosphate - Nicotinamide - Pyridine carboxylic acid or derivatives - Monosaccharide - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Pyridinium - Pyridine - Heteroaromatic compound - Vinylogous amide - Tetrahydrofuran - 1,2-diol - Carboxamide group - Secondary alcohol - Primary carboxylic acid amide - Azacycle - Oxacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organic zwitterion - Alcohol - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as nicotinamide nucleotides. These are pyridine nucleotides, in which the pyridine base is nicotinamide or a derivative thereof.
• External Descriptors: nicotinamide mononucleotide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in PBS (10 mg/ml).
• Sensibilidad: heat sensitive
• Rotación específica [α]: -24° (C=2,H2O)
• Punto de fusión (°C): 166 °C
• Peso molecular: 334.220 g/mol
• XLogP3: -3.500
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 334.057 Da
• Monoisotopic Mass: 334.057 Da
• Topological Polar Surface Area: 166.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 455.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

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