Nitrocefin - ≥90% , CAS No.41906-86-9

CAS: 41906-86-9 Cat. No.: N163020 Peso molecular: 516.5 Número EC: 636-988-0 PubChem CID: 6436140
Disponible para pedir
GRADE & PURITY ≥90%
Synonyms
(6R,7R)-7-[[(E)-4-(2,4-Dinitrophenyl)-2-(2-thienyl)but-3-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | EWP54G0J8F | (6R,7R)-3-[(E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
N163020-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
32,90US$
5mg
N163020-5mg
3
128,90US$
25mg
N163020-25mg
2
433,90US$
100mg
N163020-100mg
3
839,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥90% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Nitrocefin is a chromogenic β-lactamase substrate that undergoes colour change from yellow to red as the amide bond in the β-Lactam ring is hydrolyzed by β-lactamase. Nitrocefin undergoes colour changes induced by lactamases produced by Gram-positive and Gram-negative bacteria. Several studies have utilized the colour changing properties of Nitrocefin for the detection of β-lactamase activity from bacterial cell extracts by isoelectric focusing and spectroscopy. Nitrocefin has also been used in studies involving β-lactamase resistant antibiotics.

Specifications

Sinónimos
(6R, 7R)-7-[[(E)-4-(2, 4-Dinitrophenyl)-2-(2-thienyl)but-3-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | EWP54G0J8F | (6R, 7R)-3-[(E)-2-(2, 4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]
Especificaciones y pureza
≥90%
Mecanismos bioquímicos y fisiológicos
Chromogenic cephalosporin β-lactamase substrate. Indicates β-lactamase activity via a red color intensely proportional to the original concentration of Nitrocefin.
Condiciones de almacenamiento de almacenamiento
Store at -20°C, Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Pureza
≥90%
Nombres e identificadores
Sonrisas canónicasC1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)O)/C=C/C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]
Isómeros SMILES C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)O)/C=C/C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]
PubChem CID 6436140
Peso molecular 516.5

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (no humanos)
blaZ Beta-lactamase (285 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nmcA Imipenem-hydrolyzing beta-lactamase (46 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaPER-2 PER-2 beta-lactamase (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
bla Beta-lactamase OXA-10 (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
bla Carbepenem-hydrolyzing beta-lactamase KPC (120 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaVIM-2 Beta-lactamase VIM-2 (381 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaVIM-4 Beta-lactamase VIM-4 (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaGES-13 Beta-lactamase GES-13 (25 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Metallo-beta-lactamase VIM-11 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaVIM-2 Metallo-beta-lactamase VIM-2 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaDIM-1 Metallo-beta-lactamase (33 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pbpX Penicillin-binding protein 2X (99 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
bla OXA-48 (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaVIM-7 Metallo-b-lactamase (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
sugE Efflux transporter (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
bla Class C beta-lactamase CMY-36 (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaIND-6 Metallo-beta-lactamase IND-6 (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaB1 Carbapenem-hydrolyzing beta-lactamase BlaB-1 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot NumberCertificate TypeFechaArticulo
E2621620Certificate of AnalysisMay 09, 2026 N163020
E2621614Certificate of AnalysisMay 09, 2026 N163020
E2621598Certificate of AnalysisMay 09, 2026 N163020
E2621604Certificate of AnalysisMay 09, 2026 N163020
A2429354Certificate of AnalysisOct 29, 2025 N163020
C2202581Certificate of AnalysisSep 09, 2025 N163020
G2516034Certificate of AnalysisJul 28, 2025 N163020
H2506447Certificate of AnalysisJul 03, 2025 N163020
H2506446Certificate of AnalysisJul 03, 2025 N163020
H2506445Certificate of AnalysisJul 03, 2025 N163020
C2606349Certificate of AnalysisJul 03, 2025 N163020
B2627114Certificate of AnalysisJul 03, 2025 N163020
A2609072Certificate of AnalysisJul 03, 2025 N163020
F2513105Certificate of AnalysisJun 17, 2025 N163020
G2307136Certificate of AnalysisApr 07, 2025 N163020
G2307172Certificate of AnalysisApr 07, 2025 N163020
G2412464Certificate of AnalysisJun 26, 2024 N163020
G2412491Certificate of AnalysisJun 26, 2024 N163020
C2619598Certificate of AnalysisJun 24, 2024 N163020
C2202583Certificate of AnalysisDec 19, 2023 N163020
C2202582Certificate of AnalysisDec 19, 2023 N163020
G2307174Certificate of AnalysisDec 30, 2022 N163020

Show more ⌵

Propiedades químicas y físicas
SolubilidadDMSO (Slightly), Methanol (Slightly)
SensibilidadMoisture sensitive;Light sensitive
Punto de fusión (°C)>99℃
Peso molecular516.500 g/mol
XLogP32.200
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass516.041 Da
Monoisotopic Mass516.041 Da
Topological Polar Surface Area232.000 Ų
Heavy Atom Count35
Formal Charge0
Complexity991.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Aparna Vasudevan, Dinesh Kumar Kesavan, Liang Wu, Zhaoliang Su, Shengjun Wang, Mohan Kumar Ramasamy, Waheeta Hopper, Huaxi Xu.  (2022)  In Silico and In Vitro Screening of Natural Compounds as Broad-Spectrum β-Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo-β-lactamase-1 (NDM-1).  Biomed Research International,      [PMID:35372567] [10.1155/2022/4230788]
2. Haonan Sun, Yunjian Yu, Yufei Zhang, Jie Li, Yijie Cheng, Siyuan Huang, Wenbo Wang, Xinge Zhang.  (2021)  Glycosylated Nanotherapeutics with β-Lactamase Reversible Competitive Inhibitory Activity Reinvigorates Antibiotics against Gram-Negative Bacteria.  BIOMACROMOLECULES,      [PMID:34164980] [10.1021/acs.biomac.1c00231]
3. Maohu Chen, Bo Qiu, Zhanlin Zhang, Shuang Xie, Yuan Liu, Tian Xia, Xiaohong Li.  (2021)  Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2021.130330]
4. Dongmei Zhao, Hongru Li, Chengcheng Yue, Kaili Sun, Yuanyuan Dai, Hui Zhang, Yanyan Liu, Yufeng Gao, Jiabin Li.  (2021)  Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study.  JOURNAL OF INORGANIC BIOCHEMISTRY,      [PMID:33647540] [10.1016/j.jinorgbio.2021.111381]
5. Minrui Liu, Hongyuhang Ni, Ling Yang, Gang Chen, Xiaojun Yan, Xiaoyun Leng, Pu Liu, Xiangkai Li.  (2019)  Pretreatment of swine manure containing β-lactam antibiotics with whole-cell biocatalyst to improve biogas production.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2019.118070]
6. Lei Xu, Sangyu Hu, Yuzhu Pei, Yutong Zhou, Xiuli Zhang, Linlin Ding, Minhe Cui, Yonglin Zhou, Xuming Deng, Zihao Teng, Jianfeng Wang.  (2025)  Docosahexaenoic Acid-Driven Metabolic Reprogramming as an Attractive Anti-Infection Strategy to Potentiate β-Lactam Antibiotic Efficacy.  Research,      [PMID:41383405] [10.34133/research.0650]
7. Cheng Wenhui, Zhang Yuejuan, Chen Cheng, Gao Lei, Lv Yuwei, Yu Dian, Chen Bin, Wan Yi.  (2024)  Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48.  MEDICINAL CHEMISTRY RESEARCH,      [PMID:] [10.1007/s00044-023-03185-w]
8. Ru Wang, Kun Mi, Aihua Lu, Chengyang Zhang, Lei Sun, Yuxiang Chen, Yuanhu Pan, Yanfei Tao, Lingli Huang.  (2025)  Postβ-Lactamase-Inhibiting Effect of Sulbactam in Combination with Ceftriaxone on Extended-Spectrum-β-Lactamase-Producing Escherichia coli.  Antibiotics-Basel,  14  (9): (915).  [PMID:41009894] [10.3390/antibiotics14090915]
9. Shu-Fei Yuan, Xin-Jing Yue, Wei-Feng Hu, Ye Wang, Yue-Zhong Li.  (2023)  Genome-wide analysis of lipolytic enzymes and characterization of a high-tolerant carboxylesterase from Sorangium cellulosum.  Frontiers in Microbiology,      [PMID:38111649] [10.3389/fmicb.2023.1304233]
10. Wenyan Jiang, Shan Zhang, Chen Xu, Haojie Sun, Ziye Xing, Xiao Liang, Hongming He, Quanshun Li.  (2025)  Sustainable biodegradation of antibiotic residues in aqueous environment using OXA-48 β-lactamase encapsulated in spherical mesoporous covalent organic frameworks.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40499418] [10.1016/j.jhazmat.2025.138856]
11. Hao Tang, Xiaomeng Zhao, Mengsi Sun, Jie Qi, Zhihao Huang, Yihang Zhu, Yingmin Zeng, Yong Xia, Zhi Luo, Xingyu Jiang.  (2025)  Chemically tailored anionic antibiotic adjuvants targeting divalent cations to overcome carbapenem resistance in gram-negative bacteria.  Science Advances,  11  (43):   [PMID:41124267] [10.1126/sciadv.adz0574]
12. Jing Wu, Ziqian Xiao, Yuhui Du, Minglan Luo, Jiacheng Zhang, Pei Guo, Zhipeng Chen, Binyuan Yang, Tingjian Chen.  (2025)  Generation of Stable 2’-F/OMe-RNA Aptasensors for Bacillus cereus 5/B/6 Metallo-β-Lactamase.  ACS Synthetic Biology,      [PMID:41236492] [10.1021/acssynbio.5c00547]
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