Omeprazole - Moligand™, 10mM in DMSO , Inhibitor of ATP4A;Activator of ClC-2, CAS No.73590-58-6, Inhibitor of ATP4A;Activator of ClC-2

CAS: 73590-58-6 Cat. No.: O407783 Peso molecular: 345.42 Número EC: 615-996-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Omeprazole Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase , used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.
In vitro

Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect.

In vivo

Cell Data

cell lines：HOS, HTB-186 Daoy, TC-71, RD, SK-N-AS, SK-N-DZ, LD and KCNR cells

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Sinónimos

6-methoxy-2-((4-methoxy-3, 5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ACTIVATOR, INHIBITOR

Mecanismo de acción

Inhibitor of ATP4A;Activator of ClC-2

Nombres e identificadores

• Isómeros SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
• WGK Alemania: 2
• RTECS: DD9087000
• Peso molecular: 345.42
• Reaxy-Rn: 6489199
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6489199&ln=

Objetivos asociados (humanos)

ATP4A Tclin Potassium-transporting ATPase alpha chain 1 (0 Activities)

Discover Target: ATP4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCN2 Tclin Chloride channel protein 2 (0 Activities)

Discover Target: CLCN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 158-159°C

Referencias

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2. Yanxia Liu, Wei Du, Xiuquan Yao, Chunlin Liu, Xiaofang Luo, Lei Guo, Chao Guo.  (2023)  Electrochemical and Theoretical Study of Corrosion Inhibition on X60 Steel in H2SO4 Solution by Omeprazole.  International Journal of Electrochemical Science,      [PMID:] [10.20964/2022.04.58]

3. Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang.  (2023)  8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:37121295] [10.1016/j.abb.2023.109617]

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15. Gu Lina, Sun Ying, Bai Tingjie, Shao Sijie, Tang Shumin, Xue Panpan, Cai Wanlin, Qin Xian, Zeng Xuemei, Yan Shuangqian.  (2025)  Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-20).  [PMID:40089774] [10.1186/s12951-025-03284-3]

16. Zibo Xiong, Zhiwei Lai, Sanmu Li, Hua Zhang, Yongqiang Wang, Lishan Tan, Guang Yang, Zuying Xiong.  (2025)  Potential Kidney Risks Associated With Clinical Doses of Omeprazole: In Vivo and In Vitro Studies.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  52  (8): (e70050).  [PMID:40623774] [10.1111/1440-1681.70050]

17. Lifeng Niu, Lina Ding, Chunyun Lu, Feifei Zuo, Ke Yao, Shaobo Xu, Wen Li, Donghua Yang, Xia Xu.  (2016)  Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:27318274] [10.1016/j.jep.2016.06.039]

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19. Qian Huang, Yuqian Li, Zhiliang Gao, Yiming Shao.  (2025)  Integrative network toxicology and experimental validation reveal novel molecular mediators of omeprazole-induced nephrotoxicity.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:41265761] [10.1016/j.taap.2025.117649]

20. Feifei Zhao, Yizhen Zhu, Lingxiang Mao, Honghao Huang, Wei Wei, Qiangcheng Deng, Youzhi Tang, Ning Han, Zhenling Zeng.  (2025)  Antimicrobial Activity, Preliminary Safety, and Pharmacokinetics Assessment of 2–3: A Pleuromutilin-Derived Compound.  ACS Infectious Diseases,      [PMID:41332299] [10.1021/acsinfecdis.5c00727]

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22. Hang Yin, Lei Zhu, Xiaoyu Wang, Zhen Wang, Hecheng Wang, Yong Liu.  (2026)  Sesamin exhibits potential food–drug interactions through the inhibition of cytochrome P450s and human UDP-glucuronosyltransferases in vitro.  RSC Advances,  16  (14): (12570-12578).  [PMID:] [10.1039/D6RA00237D]