≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis .
Targets
TOPK (Cell-free assay) 2.6 nM
In vitro
OTS514 has growth inhibitory effect on five kidney cancer cell lines, VMRC-RCW, Caki-1, Caki-2, 769-P and 786-O, in which TOPK was highly expressed. The IC50 values range from 19.9 to 44.1 nM. OTS514 strongly suppressed the growth of TOPK-positive cancer cells. It also shows significant growth-inhibitory effect on ovarian cancer cell lines with IC50 values of 3.0 to 46 nM.
In vivo
Mouse xenograft studies with human lung cancer cells demonstrated the in vivo efficacy of OTS514 but found that the compound also caused severe hematopoietic toxicity [reduction of red blood cells (RBCs) and white blood cells (WBCs) associated with marked increase in platelets]. Oral administration of OTS514 significantly elongated overall survival in the ES-2 abdominal dissemination xenograft model, compared with vehicle control (P < 0.001).
Cell Research(from reference)
Cell lines：CD34+ HSCs
Concentrations：20 or 40 nM
Incubation Time：48 h
| ALogP | 4.147 |
|---|---|
| hba_count | 1 |
| Recuento HBD | 3 |
| Enlace rotable | 3 |
| Pubchem Sid | 488202565 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202565 |
| Sonrisas canónicas | CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)C(C)CN)O.Cl |
| IUPAC Name | 9-[4-[(2R)-1-aminopropan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one;hydrochloride |
| InChIKey | CQPRMBOOBXSZSP-YDALLXLXSA-N |
| INCHI | 1S/C21H20N2O2S.ClH/c1-11-9-16(24)17(14-5-3-13(4-6-14)12(2)10-22)18-15-7-8-26-20(15)21(25)23-19(11)18;/h3-9,12,24H,10,22H2,1-2H3,(H,23,25);1H/t12-;/m0./s1 |
| Isómeros SMILES | CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)[C@@H](C)CN)O.Cl |
| CAS alternativo | 1338540-63-8 |
| Peso molecular | 400.92 |
| Reaxy-Rn | 50647598 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=50647598&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Quinolines and derivatives |
| Subclass | Quinolones and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Thienoquinolines |
| Alternative Parents | Phenylquinolines Hydroquinolones Hydroxyquinolines Phenylpropylamines Aromatic monoterpenoids Hydroquinolines Thienopyridines 1-hydroxy-2-unsubstituted benzenoids Pyridinones Aralkylamines Thiophenes Heteroaromatic compounds Lactams Azacyclic compounds Hydrochlorides Hydrocarbon derivatives Organooxygen compounds Organic oxides Monoalkylamines |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylquinoline - Thienoquinoline - Hydroxyquinoline - Dihydroquinolone - P-cymene - Aromatic monoterpenoid - Dihydroquinoline - Monoterpenoid - Phenylpropylamine - Thienopyridine - Aralkylamine - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Pyridinone - Pyridine - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Thiophene - Lactam - Azacycle - Amine - Organonitrogen compound - Primary aliphatic amine - Organooxygen compound - Primary amine - Hydrochloride - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as thienoquinolines. These are heterocyclic compounds containing a thiophene ring fused to a quinoline. Quinoline or benzo[b]pyridine is a bicyclic compound that consists of benzene fused to a pyridine. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 C23031014 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031015 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031022 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031025 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031042 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031052 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031156 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031181 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031189 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| C23031196 | Certificate of Analysis | Dec 12, 2025 | O413805 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 80 mg/mL (199.54 mM); Water: 80 mg/mL (199.54 mM); Ethanol: 5 mg/mL (12.47 mM); |
|---|---|
| DMSO (mg/ml) Solubilidad máxima | 80 |
| DMSO (mM) Solubilidad máxima | 199.5410556 |
| Agua (mg/ml) Solubilidad máxima | 80 |
| Agua (mM) Solubilidad máxima | 199.5410556 |
