Piroxicam - Moligand™, 10mM in DMSO , Inhibitor of COX-1;Inhibitor of COX-2, CAS No.36322-90-4, Inhibitor of COX-1;Inhibitor of COX-2

CAS: 36322-90-4 Cat. No.: P407766 Peso molecular: 331.35 Beilstein Registry Number: 1876290 Número EC: 252-974-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CP 16171 | 4-​hydroxy-​2-​methyl-​N-​2-​pyridinyl-​1,​1-​dioxide-2H-​1,​2-​benzothiazine-​3-​carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Piroxicam Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
In vitro

Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. Piroxicam and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures.

In vivo

Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. Piroxicam increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. Piroxicam up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. Piroxicam combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. Piroxicam inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and Piroxicam does not have any direct cytotoxic effects in vitro. Piroxicam also binds strongly to plasma proteins and Piroxicam could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. Piroxicam prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats.
Cell Data

cell lines：S114, GTL-16, NCI-H441, and BxPC-3

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Sinónimos

CP 16171 | 4-​hydroxy-​2-​methyl-​N-​2-​pyridinyl-​1, ​1-​dioxide-2H-​1, ​2-​benzothiazine-​3-​carboxamide

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of COX-1;Inhibitor of COX-2

Nombres e identificadores

• Isómeros SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
• WGK Alemania: 3
• RTECS: DL0705000
• Peso molecular: 331.35
• Beilstein: 1876290
• Reaxy-Rn: 627692
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=627692&ln=

Objetivos asociados (humanos)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (1 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de inflamación (°F): 123.8 °F
• Punto de inflamación (°C): 51 °C
• Punto de fusión (°C): 198-200°C

Referencias

1. Lixue Ma, Zhaohua Li, Jiancheng Fei, Mo Li, Bingyang Liu, Baocheng Tian, Yanhua Liu, Qiang Fu.  (2023)  In vivo behaviors of meloxicam nanocrystals by intravenous administration are not significantly affected by stabilizers.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2023.104380]

2. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie.  (2022)  Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2022.101842]

3. Yu Chen, Xiaoting Yan, Jian Zhao, Huaiyu Feng, Puwang Li, Zongrui Tong, Ziming Yang, Sidong Li, Jueying Yang, Shaohua Jin.  (2018)  Preparation of the chitosan/poly(glutamic acid)/alginate polyelectrolyte complexing hydrogel and study on its drug releasing property.  CARBOHYDRATE POLYMERS,      [PMID:29661325] [10.1016/j.carbpol.2018.02.065]

4. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang.  (2025)  Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food.  ACS Sensors,      [PMID:39992799] [10.1021/acssensors.4c02806]

5. Nanjun Chen, Zichen Ning, Zhuoshan Gong, Limin Zhou, Li Xu, Feiqiang He, Zhi Gao, Jerry Y. Y. Heng, Shichao Du, Jinbo Ouyang.  (2025)  Realizing Aggregation-Induced Emission Improvement and Multistimulus-Responsive Reversible Fluorescence Switching through Multicomponent Crystals.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c01754]