Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
| ALogP | 1.6 |
|---|
| Pubchem Sid | 504750933 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750933 |
| Sonrisas canónicas | CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O |
| IUPAC Name | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| InChIKey | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| INCHI | 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
| Isómeros SMILES | C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O |
| Peso molecular | 360.44 |
| Reaxy-Rn | 2339782 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339782&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Clase | Steroids and steroid derivatives |
| Subclass | Hydroxysteroids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 21-hydroxysteroids |
| Alternative Parents | Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-oxo delta-1,4-steroids 17-hydroxysteroids 11-beta-hydroxysteroids Delta-1,4-steroids Tertiary alcohols Alpha-hydroxy ketones Secondary alcohols Cyclic ketones Cyclic alcohols and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic homopolycyclic compounds |
| Substituents | Progestogin-skeleton - 21-hydroxysteroid - 20-oxosteroid - Pregnane-skeleton - 3-oxo-delta-1,4-steroid - 3-oxosteroid - Oxosteroid - 11-beta-hydroxysteroid - 11-hydroxysteroid - 17-hydroxysteroid - Delta-1,4-steroid - Cyclic alcohol - Tertiary alcohol - Alpha-hydroxy ketone - Ketone - Secondary alcohol - Cyclic ketone - Primary alcohol - Alcohol - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Organic oxygen compound - Carbonyl group - Aliphatic homopolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. |
| External Descriptors | C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Apr 03, 2026 | P276607 | |
| Certificate of Analysis | Jan 30, 2026 | P276607 | |
| Certificate of Analysis | Jan 30, 2026 | P276607 | |
| Certificate of Analysis | Jan 30, 2026 | P276607 | |
| Certificate of Analysis | Jan 10, 2026 | P276607 | |
| Certificate of Analysis | Dec 12, 2025 | P276607 | |
| Certificate of Analysis | Dec 12, 2025 | P276607 | |
| Certificate of Analysis | Dec 12, 2025 | P276607 | |
| Certificate of Analysis | Dec 12, 2025 | P276607 | |
| Certificate of Analysis | Sep 17, 2025 | P276607 | |
| Certificate of Analysis | Sep 17, 2025 | P276607 | |
| Certificate of Analysis | Sep 17, 2025 | P276607 | |
| Certificate of Analysis | May 25, 2024 | P276607 | |
| Certificate of Analysis | Sep 20, 2023 | P276607 | |
| Certificate of Analysis | Jan 17, 2023 | P276607 | |
| Certificate of Analysis | Sep 28, 2022 | P276607 | |
| Certificate of Analysis | Sep 28, 2022 | P276607 | |
| Certificate of Analysis | Dec 24, 2021 | P276607 | |
| Certificate of Analysis | Dec 24, 2021 | P276607 | |
| Certificate of Analysis | Dec 24, 2021 | P276607 |
| Solubilidad | Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride. It shows polymorphism |
|---|---|
| Punto de inflamación (°C) | 2℃ |
| Punto de ebullición (°C) | 412.46°C (rough estimate) |
| Punto de fusión (°C) | 240 °C (dec.)(lit.) |
| Peso molecular | 360.400 g/mol |
| XLogP3 | 1.600 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 360.194 Da |
| Monoisotopic Mass | 360.194 Da |
| Topological Polar Surface Area | 94.800 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 724.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 7 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv. (2023) Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects. CHEMISTRY & BIODIVERSITY, [PMID:38129310] [10.1002/cbdv.202301525] |
| 2. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). [PMID:37764395] [10.3390/molecules28186619] |
| 3. Yunjia Wang, Zhongjing Jiang, Linhua Deng, Gengming Zhang, Xia Xu, Emmanuel Alonge, Hongqi Zhang, Chaofeng Guo. (2023) Dendrobium offificinale polysaccharides prevents glucocorticoids-induced osteoporosis by destabilizing KEAP1-NRF2 interaction. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37652317] [10.1016/j.ijbiomac.2023.126600] |
| 4. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, [PMID:37126925] [10.1016/j.talanta.2023.124589] |
| 5. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, [PMID:37116443] [10.1016/j.foodchem.2023.136196] |
| 6. Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li. (2023) Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:36996741] [10.1016/j.intimp.2023.110079] |
| 7. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). [PMID:36207561] [10.1208/s12249-022-02427-1] |
| 8. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li. (2020) Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:32173426] [10.1016/j.jep.2020.112764] |
| 9. Shoubao Wang, Yao Xiong, Yinmin Wang, Jingting Chen, Jun Yang, Binbin Sun. (2020) Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study. TRANSPLANT INTERNATIONAL, 33 (4): (450-461). [PMID:31930539] [10.1111/tri.13574] |
| 10. Jia-Bi Lin, Hao Wu, Yu-Ling Liu, Pang-Chui Shaw, Pei-Bo Li. (2018) Transcriptome analysis reveals functional roles of nacreous protein N16 in prednisolone-induced osteoporotic zebrafish. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:30219513] [10.1016/j.ijbiomac.2018.09.055] |
| 11. Guozheng Zhao. (2024) Detection of six glucocorticoids using a nanogold-glucocorticoid receptor-based biosensor. CHEMICAL PHYSICS LETTERS, [PMID:] [10.1016/j.cplett.2024.141611] |
| 12. Guowen Li, Mengjia Chao, Chun Zhang, Hang Gao, Xiuping Li, Hongxin Ren, Xinlin Wei, Chifang Peng, Wei Ma, Zhouping Wang. (2025) Supraparticle Nanoarchitectonics with Bright Gold Nanoclusters Induced by Host–Guest Recognition for Volatile Amine and Meat Freshness Detection. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.5c00366] |
| 13. Jiadi Shen, Chenyu Weng, Shuxian Zhu, Wanjing Chen, Xuening Xiong, Xin Wei. (2025) Protein Phosphatases 2A Affects Drug Resistance of Candida albicans Biofilm Via ATG Protein Phosphorylation Induction. INTERNATIONAL DENTAL JOURNAL, [PMID:40885126] [10.1016/j.identj.2025.103873] |
| 14. Jiadi Shen, Yuzhi Li, Haochen Miao. (2025) The PP2A Catalytic Subunit PPH21 Regulates Biofilm Formation and Drug Resistance of Candida albicans. Microorganisms, 13 (9): (2093). [PMID:41011426] [10.3390/microorganisms13092093] |
| 15. Yi Tao, Lin Chen, Meiling Pan, Fei Zhu, Jizhong Yan. (2021) Tracing anti-osteoporosis components from raw and salt-processed semen of Cuscuta chinensis by employing a biochemometrics strategy that integrates ultrasonic-assisted extraction, quantitation, efficacy assessment in zebrafish, and grey relationship analysis. JOURNAL OF SEPARATION SCIENCE, 44 (17): (3229-3236). [PMID:34240804] [10.1002/jssc.202100272] |
| 16. Rong Huang, Wenyu Zhang, Yueqi Hu, Junjie Xu, Zhihui Dong, Jikai Liu, Li Zhou. (2025) Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:40393586] [10.1016/j.ijbiomac.2025.144264] |
| 17. Yuan-Yuan Yang, Bao-Zhu Jia, Zhen-Lin Xu, Yi-Xian Liu, Lin Luo. (2025) Magnetic Particle-Based Automated Chemiluminescence Immunoassay for the Determination of Hydrocortisone Residues in Milk. Foods, 14 (12): (2105). [PMID:40565714] [10.3390/foods14122105] |
| 18. Xiaolu Chen, Muyao Cui, Jiaqi Li, Qi Chen, Linzhen Chen, Zhuo Yang, Qiqi Fan, Yuhan Sheng, Ruichao Lin, Zhiqiang Ma, Chongjun Zhao. (2025) Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models. Frontiers in Immunology, [PMID:41394814] [10.3389/fimmu.2025.1722777] |
| 19. Jiang Cheng, Naihui Hou, Tengda Wang, Zhenyun Zhao\u003Csup\u003E*\u003C\u002Fsup\u003E, Wei Chen\u003Csup\u003E*\u003C\u002Fsup\u003E. (2026) Dual-function core-shell nanocube probes enabling continuous production of cortisol-sensing yarns via conjugate electrospinning. Soft Science, 6 (2): (N). [PMID:] [10.20517/ss.2025.123] |