Probucol - Moligand™, 10mM in DMSO , ATP-binding cassette sub-family A member 1 inhibitor, CAS No.23288-49-5, ATP-binding cassette sub-family A member 1 inhibitor

CAS: 23288-49-5 Cat. No.: P408795 Peso molecular: 516.84 Número EC: 245-560-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Probucol Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

DH-581 | 4, ​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2, ​6-​bis(1, ​1-​dimethylethyl)​-phenol

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

ATP-binding cassette sub-family A member 1 inhibitor

Propiedades del producto

• ALogP: 11.3

Nombres e identificadores

• Isómeros SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
• RTECS: AL3705000
• Peso molecular: 516.84
• Reaxy-Rn: 2026253
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2026253&ln=

Objetivos asociados (humanos)

HPN Tchem Serine protease hepsin (1 Activities)

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro
• Punto de fusión (°C): 128°C

Referencias

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]

2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang.  (2019)  Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol.  CARBOHYDRATE POLYMERS,      [PMID:31826471] [10.1016/j.carbpol.2019.115508]