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PROTAC CDK12/13 Degrader-1 TFA , CAS No.P658854
Disponible para pedir
Storage
Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Protected from light,Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
PROTAC CDK12/13 Degrader-1 (7f) TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 TFA has anti-proliferative activity and can be use
Appearance:Solid
IC50& Target:CDK12 2.2 nM (DC 50 ) CDK13 2.1 nM (DC 50 )
In Vitro:PROTAC CDK12/13 Degrader-1 (7f) TFA (0.02-10 μM, 150 h) significantly inhibits the proliferation of MFM223 and MDA-MB-231 cells in a dose-dependent manner. PROTAC CDK12/13 Degrader-1 (7f) TFA (500 nM, 4 h) can significantly degrade CDK12 and CDK13 of
In Vivo:The pharmacokinetic parameters of PROTAC CDK12/13 Degrader-1 (7f) TFA in rats. Parameters oral (20mg/kg) iv (10mg/kg) ip (20mg/kg) iv (2.5mg/kg) t 1/2 (h) - 5.28 10.85 5.8 T max (h) 5.33 0.08 2.17 0.08 C max (ng/mL) 7.73 19892.4 24.79 1498.5 C ma
Biological Activity:PROTAC CDK12/13 Degrader-1 (7f) TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 TFA has anti-proliferative activity and can be use
Specifications
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C, Desiccated
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
DEGRADER
Nombres e identificadores
| Peso molecular | 936.93 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 25 mg/mL (26.68 mM; ultrasonic and warming and heat to 60°C) |
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Calculadoras de soluciones
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