QS11 - ≥98% , CAS No.944328-88-5

CAS: 944328-88-5 Cat. No.: Q274976 Peso molecular: 567.68 PubChem CID: 42623900

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QS11 - ≥98% CAS No(944328-88-5) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥98%

Synonyms

MLS006010863 | QS11 | Q27166329 | BDBM50373058 | QS11 free | BDBM12590 | (2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol | BRD-K02526760-001-01-5 | AKOS024457553 | Wnt Synergist, QS11 | (2S)-2-({9-

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Product description

QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 µM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells.

Specifications

Sinónimos

MLS006010863 | QS11 | Q27166329 | BDBM50373058 | QS11 free | BDBM12590 | (2S)-2-[[2-(2, 3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol | BRD-K02526760-001-01-5 | AKOS024457553 | Wnt Synergist, QS11 | (2S)-2-({9-

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Potent GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor (EC 50 = 0.5 μM). Wnt/β-catenin pathway modulator. Antitumor agent. Active in vitro .

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

Pubchem Sid	504770198
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770198
Sonrisas canónicas	C1CC2=C(C1)C=C(C=C2)OC3=NC(=C4C(=N3)N(C=N4)CC5=CC=C(C=C5)C6=CC=CC=C6)NC(CC7=CC=CC=C7)CO
IUPAC Name	(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol
InChIKey	DOKZLKDGUQWMSX-HKBQPEDESA-N
INCHI	1S/C36H33N5O2/c42-23-31(20-25-8-3-1-4-9-25)38-34-33-35(40-36(39-34)43-32-19-18-28-12-7-13-30(28)21-32)41(24-37-33)22-26-14-16-29(17-15-26)27-10-5-2-6-11-27/h1-6,8-11,14-19,21,24,31,42H,7,12-13,20,22-23H2,(H,38,39,40)/t31-/m0/s1
Isómeros SMILES	C1CC2=C(C1)C=C(C=C2)OC3=NC(=C4C(=N3)N(C=N4)CC5=CC=C(C=C5)C6=CC=CC=C6)N[C@@H](CC7=CC=CC=C7)CO
PubChem CID	42623900
Peso molecular	567.68

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Clase Benzene and substituted derivatives
    - Subclass Biphenyls and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Clase	Benzene and substituted derivatives
Subclass	Biphenyls and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biphenyls and derivatives
Alternative Parents	Diarylethers 6-alkylaminopurines Amphetamines and derivatives Indanes Secondary alkylarylamines Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Heteroaromatic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Biphenyl - Diaryl ether - 6-alkylaminopurine - 6-aminopurine - Amphetamine or derivatives - Imidazopyrimidine - Indane - Purine - Aminopyrimidine - Secondary aliphatic/aromatic amine - N-substituted imidazole - Imidolactam - Pyrimidine - Azole - Heteroaromatic compound - Imidazole - Secondary amine - Ether - Azacycle - Organoheterocyclic compound - Amine - Organooxygen compound - Hydrocarbon derivative - Primary alcohol - Organopnictogen compound - Organonitrogen compound - Alcohol - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

ARF1 Tchem ADP-ribosylation factor 1 (1 Activities)

Discover Target: ARF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

5637 (630 Activities)

Lot Number	Certificate Type	Fecha	Articulo
C23021044	Certificate of Analysis	Sep 19, 2024	Q274976
C23021189	Certificate of Analysis	Sep 19, 2024	Q274976
C23021197	Certificate of Analysis	Sep 19, 2024	Q274976
C23021201	Certificate of Analysis	Sep 19, 2024	Q274976
C23021278	Certificate of Analysis	Sep 19, 2024	Q274976

Solubilidad	Soluble in DMSO to 100 mM and in ethanol to 100 mM
Sensibilidad	light sensitive
Peso molecular	567.700 g/mol
XLogP3	7.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	567.263 Da
Monoisotopic Mass	567.263 Da
Topological Polar Surface Area	85.100 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	841.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1