RK-33 - ≥98% , CAS No.1070773-09-9

CAS: 1070773-09-9 Cat. No.: R413953 Peso molecular: 428.44 PubChem CID: 46184988

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RK-33 - ≥98% CAS No(1070773-09-9) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥98%

Synonyms

2H-Diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one,3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]- | RK33 | RK 33 | RK-33 | 3,7-bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general Specifications Propiedades del producto Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Targets

DDX3

In vitro

RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity.

In vivo

RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes.

Cell Research(from reference)

Cell lines：MDA-MB-231 cells

Concentrations：7.5 μM

Incubation Time：12 h

Specifications

Sinónimos

2H-Diimidazo[4, 5-d:4', 5'-f][1, 3]diazepin-2-one, 3, 7-dihydro-3, 7-bis[(4-methoxyphenyl)methyl]- | RK33 | RK 33 | RK-33 | 3, 7-bis(4-methoxybenzyl)-3, 7-dihydro-2H-diimidazo[4, 5-d:4', 5'-f][1, 3]diazepin-2-one

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Propiedades del producto

ALogP	2.687
Enlace rotable	6

Nombres e identificadores

Pubchem Sid	488201261
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201261
Sonrisas canónicas	COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
IUPAC Name	5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one
InChIKey	COUMZXFUZDBRCZ-UHFFFAOYSA-N
INCHI	1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
Isómeros SMILES	COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
PubChem CID	46184988
Peso molecular	428.44

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Clase Imidazodiazepines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Clase	Imidazodiazepines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Imidazodiazepines
Alternative Parents	Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers 1,3-diazepines N-substituted imidazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Imidazo-meta-diazepine - Imidazodiazepine - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Meta-diazepine - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - N-substituted imidazole - Azole - Heteroaromatic compound - Imidazole - Azacycle - Ether - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as imidazodiazepines. These are organic compounds containing an imidazole ring fused to a diazepine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Diazepine is a 7-membered ring consisting of five carbon and two nitrogen atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

Daoy (570 Activities)

Lot Number	Certificate Type	Fecha	Articulo
F23281030	Certificate of Analysis	Apr 03, 2026	R413953
F23281035	Certificate of Analysis	Apr 03, 2026	R413953
F23281036	Certificate of Analysis	Apr 03, 2026	R413953
F23281037	Certificate of Analysis	Apr 03, 2026	R413953
F23281038	Certificate of Analysis	Apr 03, 2026	R413953
F23281039	Certificate of Analysis	Apr 03, 2026	R413953
F23281040	Certificate of Analysis	Apr 03, 2026	R413953
F23281042	Certificate of Analysis	Apr 03, 2026	R413953
F23281043	Certificate of Analysis	Apr 03, 2026	R413953
F23281044	Certificate of Analysis	Apr 03, 2026	R413953

Solubilidad	Solubility (25°C) In vitro DMSO: 85 mg/mL (198.39 mM); Water: Insoluble; Ethanol: Insoluble;
Sensibilidad	Moisture sensitive.
DMSO (mg/ml) Solubilidad máxima	85
DMSO (mM) Solubilidad máxima	198.3941742
Agua (mg/ml) Solubilidad máxima	＜1
Peso molecular	428.400 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	428.16 Da
Monoisotopic Mass	428.16 Da
Topological Polar Surface Area	93.700 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	783.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1