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Ro 08-2750 - ≥95%(HPLC) , CAS No.37854-59-4

CAS: 37854-59-4 Cat. No.: R288247 Peso molecular: 270.24 PubChem CID: 17756791
COA
Ro 08-2750 - ≥95%(HPLC) CAS No(37854-59-4) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY ≥95%(HPLC)
Synonyms
SCHEMBL15683182 | HMS3677A14 | 7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde | NCGC00159546-01 | 7,10-DIMETHYL-2,4-DIOXO-2H,3H,4H,10H-BENZO[G]PTERIDINE-8-CARBALDEHYDE | CHEBI:92012 | 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-diox
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
R288247-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
208,90US$
10mg
R288247-10mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
445,90US$
50mg
R288247-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
1.827,90US$
Enter a quantity for the sizes you want to add.
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Preguntas frecuentes y artículos Calculadoras de soluciones Reseñas
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Why this grade

≥95%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Sinónimos
SCHEMBL15683182 | HMS3677A14 | 7, 10-dimethyl-2, 4-dioxo-2, 3, 4, 10-tetrahydrobenzo[g]pteridine-8-carbaldehyde | NCGC00159546-01 | 7, 10-DIMETHYL-2, 4-DIOXO-2H, 3H, 4H, 10H-BENZO[G]PTERIDINE-8-CARBALDEHYDE | CHEBI:92012 | 2, 3, 4, 10-Tetrahydro-7, 10-dimethyl-2, 4-diox
Especificaciones y pureza
≥95%(HPLC)
Mecanismos bioquímicos y fisiológicos
Non-peptide inhibitor of NGF that binds the NGF dimer (KD~ 1μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTRat submicromolar concentrations, and to both p75NTRand TrkA at concentrations > 5μM. Prevents NGF-induce
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Pureza
≥95%(HPLC)
Nombres e identificadores
Sonrisas canónicasCC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C
IUPAC Name7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde
InChIKeyJDEMVNYMYPJJIM-UHFFFAOYSA-N
INCHI1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20)
Isómeros SMILES CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C
PubChem CID 17756791
Peso molecular 270.24

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClasePteridines and derivatives
SubclassAlloxazines and isoalloxazines
Intermediate Tree Nodes Not available
Direct ParentFlavins
Alternative Parents Quinoxalines  Pyrimidones  Aryl-aldehydes  Pyrazines  Benzenoids  Vinylogous amides  Heteroaromatic compounds  Lactams  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Flavin - Diazanaphthalene - Quinoxaline - Pyrimidone - Aryl-aldehyde - Pyrazine - Pyrimidine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Lactam - Azacycle - Aldehyde - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as flavins. These are compounds containing a flavin (7,8-dimethyl-benzo[g]pteridine-2,4-dione) moiety, with a structure characterized by an isoalloaxzine tricyclic ring.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
NGF Tchem Beta-nerve growth factor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NGFR Tclin Low affinity neurotrophin receptor p75NTR (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NTRK1 Tclin Nerve growth factor receptor Trk-A (7922 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NGF Tchem Beta-nerve growth factor (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP2 Tchem Tyrosyl-DNA phosphodiesterase 2 (864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SolubilidadSolvent:DMSO, Max Conc. mg/mL: 2.7, Max Conc. mM: 10 with gentle warming
Peso molecular270.240 g/mol
XLogP30.300
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass270.075 Da
Monoisotopic Mass270.075 Da
Topological Polar Surface Area91.200 Ų
Heavy Atom Count20
Formal Charge0
Complexity554.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Nerve Growth Factor: Molecular Features, Signaling Mechanisms, and Key Technical Application Points
Categories: Technical articles
Tags:
nerve growth factor NGF TrkA p75NTR PC12 axonal growth nerve regeneration pain neurotrophins
Calculadoras de soluciones
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