S-Me-DM1 , CAS No.912569-84-7

CAS: 912569-84-7 Cat. No.: S276125 Peso molecular: 752.31 PubChem CID: 154705356

Synonyms

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

Specifications

Sinónimos

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Mecanismos bioquímicos y fisiológicos

Active metabolite of Maytansine that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Nombres e identificadores

• Sonrisas canónicas: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCSC)C)C)OC)(NC(=O)O2)O
• IUPAC Name: [(1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-methylsulfanylpropanoyl)amino]propanoate
• InChIKey: PLYHSTGTQYPYMT-UDXCHANISA-N
• INCHI: 1S/C36H50ClN3O10S/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28+,32+,35+,36+/m1/s1
• PubChem CID: 154705356
• Peso molecular: 752.31

Propiedades químicas y físicas

• Solubilidad: Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH