SB203580 - Moligand™, 10mM in DMSO , Inhibitor of cyclin G associated kinase;Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 14, CAS No.152121-47-6, Inhibitor of cyclin G associated kinase;Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 14
SB203580 - Moligand™, 10mM in DMSO , Inhibitor of cyclin G associated kinase;Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 14, CAS No.152121-47-6, Inhibitor of cyclin G associated kinase;Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 14
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Information
In vitro
SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.
In vivo
SB203580 protects pig myocardium against ischemic injury in an in vivo model. SB203580 is effective to prevent and treat the disease in MRL/lpr mice model of Systemic lupus erythematosus (SLE). Cell Data
cell lines：
Concentrations：0–30 μM
Incubation Time：1 hour
Powder Purity:≥99%
Specifications
Sinónimos
RWJ 64809, PB 203580
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
SB203580 (RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
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Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Inhibitor of cyclin G associated kinase;Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 14
1.Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu. (2022) Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (14):(7666). [PMID:35887010][10.3390/ijms23147666]
2.Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zhao. (2023) IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46 (1):(26-34). [PMID:36596524][10.1248/bpb.b22-00439]
3.Ruiling Zhuo, Xiaokang Zhang, Yong Chen, Mengyang Xing, Shiping Tian, Boqiang Li. (2024) 3-hydroxycoumarin effectively inhibits development and pathogenicity by targeting Pempk proteins of Penicillium expansum. POSTHARVEST BIOLOGY AND TECHNOLOGY, [PMID:][10.1016/j.postharvbio.2024.112987]
4.Jia Song, Jinyu Qiao, Mingxue Chen, Jiahui Li, Jixia Wang, Dayong Yu, Huachuan Zheng, Liying Shi. (2025) Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway. PeerJ, [PMID:40183046][10.7717/peerj.19085]
5.Aonan Xia, Yang Jiang, Yuan-Kun Lee, Dong Liang, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Wei Chen. (2024) Identification and validation of fermented milk-derived osteogenic peptides via molecular docking and osteoblastic cell model. Food Bioscience, [PMID:][10.1016/j.fbio.2024.103698]
6.Shiyin Zhong, Qiongli Zhou, Jirui Yang, Zhimin Zhang, Xueting Chai, Jinghao Luo, Xin Zhang, Jingjing Liu, Yangzong Yixi, Lei Shi, Xuhong Chang, Hui Wang. (2026) The Role and Mechanism of the cGAS–STING/NLRP3 Signaling Axis-Regulated p38 MAPK/NF–κB Pathway in Manganese-Induced Tau Aggregation-Mediated Neurotoxicity. Environment & Health, [PMID:][10.1021/envhealth.5c00504]
7.Yuan Yin, Panyang Gu, Hanyu Jiang, Yumei Yang, Shujun Wang, Fei Yuan, Wenrui Zhong, Miao Chen, Meichun Deng. (2026) High-dose polystyrene nanoparticles trigger aberrant activation of the MAPK pathway in spinal cord and pain hypersensitivity. JOURNAL OF NANOBIOTECHNOLOGY, [PMID:41772688][10.1186/s12951-026-04186-8]
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