Sulfadiazina de plata - ≥98% , Bacterial dihydropteroate synthase inhibitor, CAS No.22199-08-2, Bacterial dihydropteroate synthase inhibitor

CAS: 22199-08-2 Cat. No.: S104514 Peso molecular: 357.14 Número EC: 244-834-5 PubChem CID: 441244

GRADE & PURITY ≥98%

Synonyms

4-amino-N-(2-pirimidinil)bencenosulfonamida sal de plata | SULFADIAZINA DE PLATA [LIBRO VERDE] | (4-Amino-N-2-pirimidinilbencenosulfonamidato-NN,01)-plata | Kit RayaSore | Sildaflo | SULFADIAZINA DE PLATA | N(sup 1)-2-Pirimidinilsulfanilamida monosilver(1

Storage

Room temperature

Shipped In

Normal

Specifications

Sinónimos

4-amino-N-(2-pirimidinil)bencenosulfonamida sal de plata | SULFADIAZINA DE PLATA [LIBRO VERDE] | (4-Amino-N-2-pirimidinilbencenosulfonamidato-NN, 01)-plata | Kit RayaSore | Sildaflo | SULFADIAZINA DE PLATA | N(sup 1)-2-Pirimidinilsulfanilamida monosilver(1

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Tipo de acción

INHIBITOR

Mecanismo de acción

Bacterial dihydropteroate synthase inhibitor

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 488189774
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488189774
• Sonrisas canónicas: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
• IUPAC Name: silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
• InChIKey: UEJSSZHHYBHCEL-UHFFFAOYSA-N
• INCHI: 1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
• Isómeros SMILES: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
• WGK Alemania: 2
• RTECS: WP1950000
• PubChem CID: 441244
• Peso molecular: 357.14
• Reaxy-Rn: 924042

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonamides
• Alternative Parents: Benzenesulfonyl compounds Aniline and substituted anilines Pyrimidines and pyrimidine derivatives Sulfonyls Organosulfonic acids and derivatives Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organic zwitterions Organic silver salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzenesulfonamide - Benzenesulfonyl group - Aniline or substituted anilines - Pyrimidine - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Heteroaromatic compound - Organoheterocyclic compound - Azacycle - Organic transition metal salt - Amine - Organic salt - Organic zwitterion - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary amine - Organosulfur compound - Organonitrogen compound - Organic nitrogen compound - Organic silver salt - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
• External Descriptors: silver salt - sulfonamidate - pyrimidines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

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Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

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Acinetobacter baumannii (41033 Activities)

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lef Anthrax lethal factor (7585 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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PYK Pyruvate kinase (6726 Activities)

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ddn Putative uncharacterized protein (49 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: light sensitive
• Punto de fusión (°C): 285 °C(dec.)
• Peso molecular: 357.140 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 355.95 Da
• Monoisotopic Mass: 355.95 Da
• Topological Polar Surface Area: 95.300 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 327.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Mengying Chen, Huaping Tan, Weijie Xu, Zijia Wang, Jinglei Zhang, Shengke Li, Tianle Zhou, Jianliang li, Xiaohong Niu.  (2022)  A self-healing, magnetic and injectable biopolymer hydrogel generated by dual cross-linking for drug delivery and bone repair.  Acta Biomaterialia,      [PMID:36152907] [10.1016/j.actbio.2022.09.036]

2. Sirui He, Jia Liu, Shu He, An Liu, Wei Shao.  (2022)  Double crosslinked polyvinyl alcohol/gelatin/silver sulfadiazine sponges with excellent antibacterial performance.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.128737]

3. Shoukang Du, Xiaojin Chen, Xiaofei Chen, Shengke Li, Guoliang Yuan, Tianle Zhou, Jianliang Li, Yang Jia, Dangsheng Xiong, Huaping Tan.  (2019)  Covalent Chitosan-Cellulose Hydrogels via Schiff-Base Reaction Containing Macromolecular Microgels for pH-Sensitive Drug Delivery and Wound Dressing.  MACROMOLECULAR CHEMISTRY AND PHYSICS,  220  (23): (1900399).  [PMID:] [10.1002/macp.201900399]

4. Sugunya Potiwiput, Huaping Tan, Guoliang Yuan, Shengke Li, Tianle Zhou, Jianliang Li, Yang Jia, Dangsheng Xiong, Xiaohong Hu, Zhonghua Ling, Yong Chen.  (2019)  Dual-crosslinked alginate/carboxymethyl chitosan hydrogel containing in situ synthesized calcium phosphate particles for drug delivery application.  MATERIALS CHEMISTRY AND PHYSICS,      [PMID:] [10.1016/j.matchemphys.2019.122354]

5. Sa Liu, Chunting Zhong, Weiwei Wang, Yongguang Jia, Lin Wang, Li Ren.  (2018)  α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine.  Polymers,  10  (2): (190).  [PMID:30966226] [10.3390/polym10020190]

6. Wei Shao, Jimin Wu, Shuxia Wang, Min Huang, Xiufeng Liu, Rui Zhang.  (2016)  Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings.  CARBOHYDRATE POLYMERS,      [PMID:27987918] [10.1016/j.carbpol.2016.11.087]

7. Wei Shao, Hui Liu, Jimin Wu, Shuxia Wang, Xiufeng Liu, Min Huang, Peng Xu.  (2016)  Preparation, antibacterial activity and pH-responsive release behavior of silver sulfadiazine loaded bacterial cellulose for wound dressing applications.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2016.02.019]

8. Xinwei Tao, Zijia Wang, Bowen Ren, Jianliang Li, Tianle Zhou, Huaping Tan, Xiaohong Niu.  (2024)  High-flexible chitosan-based composite membrane with multi-layer biopolymer coatings for anti-bacterial drug delivery and wound healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39208887] [10.1016/j.ijbiomac.2024.134829]

9. Xinming Wang, Haonan Zhang, Weichang Xie, Bei Qian, Shixing Huang, Qiang Zhao, Xiaofeng Ye.  (2025)  Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing.  Materials Today Bio,      [PMID:40255583] [10.1016/j.mtbio.2025.101734]