Silimarina - ≥80% , CAS No.65666-07-1

CAS: 65666-07-1 Cat. No.: S304299 Peso molecular: 482.44 Número EC: 613-830-9 PubChem CID: 5213

GRADE & PURITY ≥80%

Synonyms

HMS1608M08 | MFCD00872186 | MLS000028529 | SY067261 | Flavobin Spofa | NCGC00089738-02 | SR-01000000093-6 | CHEBI:125451 | NCGC00018179-04 | Apihepar | FT-0775414 | MLS006011786 | Silybin | Silybine | SMR000058272 | BBL027841 | Q27216069 | Silybin; Silibi

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

Introducción del producto

La silimarina es un lignano flavonoide derivado de las plantas de cardo mariano (silimarina).

Aplicación

La silimarina se ha utilizado en investigación:

Sus actividades antiviral, antibacteriana, antifúngica y citotoxicidad in vitro

Efectos de la silimarina en la contracción de la vejiga en un modelo de cistitis inducida por ciclofosfamida (CYP) en ratas

Su efecto en la intoxicación hepática inducida por fumonisina B1 en ratones

Specifications

Sinónimos

HMS1608M08 | MFCD00872186 | MLS000028529 | SY067261 | Flavobin Spofa | NCGC00089738-02 | SR-01000000093-6 | CHEBI:125451 | NCGC00018179-04 | Apihepar | FT-0775414 | MLS006011786 | Silybin | Silybine | SMR000058272 | BBL027841 | Q27216069 | Silybin; Silibi

Especificaciones y pureza

≥80%

Mecanismos bioquímicos y fisiológicos

La silimarina tiene actividad cardioprotectora contra el infarto de miocardio inducido por isquemia reperfusión en ratas. La silimarina era originalmente un conocido agente que protegía el hígado de diversas sustancias tóxicas y se utilizaba para tratar l

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Tipo de acción

INHIBITOR

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥80%

Nombres e identificadores

• Pubchem Sid: 504750855
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750855
• Sonrisas canónicas: COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
• IUPAC Name: 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
• InChIKey: SEBFKMXJBCUCAI-UHFFFAOYSA-N
• INCHI: 1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
• Isómeros SMILES: COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
• PubChem CID: 5213
• Peso molecular: 482.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lignans, neolignans and related compounds
    • Clase Flavonolignans

• Kingdom: Organic compounds
• Superclass: Lignans, neolignans and related compounds
• Clase: Flavonolignans
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Flavonolignans
• Alternative Parents: 3-hydroxyflavonoids 5-hydroxyflavonoids 7-hydroxyflavonoids Flavanonols Phenylbenzo-1,4-dioxanes Chromones Methoxyphenols Benzo-1,4-dioxanes Phenoxy compounds Anisoles Methoxybenzenes Aryl alkyl ketones 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Alkyl aryl ethers Para dioxins Vinylogous acids Secondary alcohols Oxacyclic compounds Polyols Organic oxides Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Flavonolignan - Hydroxyflavonoid - 3-hydroxyflavonoid - Flavanonol - Flavanone - 7-hydroxyflavonoid - 5-hydroxyflavonoid - Flavan - Phenylbenzodioxane - 2-phenylbenzo-1,4-dioxane - Chromone - 1-benzopyran - Methoxyphenol - Benzopyran - Chromane - Benzodioxane - Benzo-1,4-dioxane - Phenoxy compound - Anisole - Methoxybenzene - Aryl alkyl ketone - Aryl ketone - Phenol ether - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Phenol - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Para-dioxin - Monocyclic benzene moiety - Vinylogous acid - Secondary alcohol - Ketone - Polyol - Organoheterocyclic compound - Ether - Oxacycle - Alcohol - Organooxygen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as flavonolignans. These are non-conventional lignans that derived from flavonoids. They are characterized by a p-dioxin ring substituted at one carbon atom by a C3C6 (phenylpropan) group and fused to the B-ring of the 2-phenylchromene moiety.
• External Descriptors: Dihyroflavonols

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: Light sensitive
• Punto de inflamación (°C): 274.4℃
• Punto de ebullición (°C): 793℃ at 760 mmHg
• Peso molecular: 482.400 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 4
• Exact Mass: 482.121 Da
• Monoisotopic Mass: 482.121 Da
• Topological Polar Surface Area: 155.000 Ų
• Heavy Atom Count: 35
• Formal Charge: 0
• Complexity: 750.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 4
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

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