Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 26 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selectiveestrogen receptormodulator (SERM). Tamoxifen enhances theHsp90molecular chaperoneATPaseactivity. Tamoxifen inducesapoptosis.
In vitro
TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)
In vivo
Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models.
Cell Data
cell lines:CLL B cells or healthy volunteer T cells or NK cells
Concentrations:10-6\u2009mol/L
Incubation Time:24, 48, and 96\u2009h
Powder Purity:≥99%
| Isómeros SMILES | CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 |
|---|---|
| WGK Alemania | 3 |
| RTECS | KR5919600 |
| CAS alternativo | 10540-29-1,54965-24-1 (citrate) |
| Número NSC | 727681 |
| Términos de entrada MeSH | Citrate, Tamoxifen;ICI 46,474;ICI 46474;ICI 47699;ICI-46,474;ICI-46474;ICI-47699;ICI46,474;ICI46474;ICI47699;Nolvadex;Novaldex;Soltamox;Tamoxifen;Tamoxifen Citrate;Tomaxithen;Zitazonium |
| Peso molecular | 371.51 |
| Reaxy-Rn | 2062019 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062019&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Solubilidad | Solubility (25°C) In vitro DMSO: 31 mg/mL (198.37 mM); Ethanol: 31 mg/mL (198.37 mM); Water: 16 mg/mL (102.38 mM); |
|---|---|
| Punto de fusión (°C) | 97-98 °C (lit.) |
| 1. Li Wanqian, Whiteway Malcolm, Hang Sijin, Yu Jinhua, Lu Hui, Jiang Yuanying. (2025) Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities. Nature Communications, 16 (1): (1-18). [PMID:40707518] [10.1038/s41467-025-62131-z] |
| 2. Yuan-yuan Zhai, Qiang Wang, Qi-yao Nong, Mei-yu Gao, Ying Zhang, Qin-wen Xiao, Yuan Tian, Zun-jian Zhang, Feng-guo Xu, Pei Zhang. (2025) Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis. BIOCHEMICAL PHARMACOLOGY, [PMID:40684995] [10.1016/j.bcp.2025.117183] |
| 3. Daoming Chen, Zhou Yu, Wenbo Wu, Yingxue Du, Qianqian Du, Huanwei Huang, Yaqi Li, Ting Xuan, Ya-Chen Liang, Yang Liu, Zijuan Wang, Rina Su, Yi Zhao, Qi Li, Minmin Luo, Fengchao Wang, Ji Li, Cheng-Ming Chuong, Zhimiao Lin, Ting Chen. (2025) Fibroblast bioelectric signaling drives hair growth. CELL, [PMID:40818454] [10.1016/j.cell.2025.07.035] |
| 4. Tao Qin, Tao Jiang, Zihan Zhou, Mengyuan Wu, Yuanzhen Zhang, Zhenqi Yang, Ziyang Zheng, Jiang Yi, Xiaowei Wang, Mingran Luo, Peng Gao, Jiayun Liu, Yifan Huang, Hao Liu, Qingqing Li, Wei Zhou, Shujun Zhang, Xiaodong Guo, Baorong He, Yongxiang Wang, Jin Fan, Shujie Zhao, Jian Chen, Guoyong Yin. (2025) Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism. NEURON, [PMID:41027425] [10.1016/j.neuron.2025.09.001] |
| 5. Yang He, Taohui Liu, Quansheng He, Wei Ke, Xiaoyu Li, Jinjin Du, Suixin Deng, Zhenfeng Shu, Jialin Wu, Baozhi Yang, Yuqing Wang, Ying Mao, Yanxia Rao, Yousheng Shu, Bo Peng. (2023) Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner. eLife, [PMID:38131301] [10.7554/eLife.92252] |
| 6. Qiong Luo, Yijun Liu, Ke Shi, Xuecheng Shen, Yaqi Yang, Xuejiao Liang, Liangliang Lu, Wenxuan Qiao, Airu Chen, Dongmei Hong, Yang Sun, Qiang Xu. (2023) An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression. IMMUNITY, [PMID:37473759] [10.1016/j.immuni.2023.06.012] |
| 7. Yuhong Li, Shuying Hu, Yueqi Chen, Xing Zhang, Hanchi Gao, Jing Tian, Jian Chen. (2023) Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway. PHYTOMEDICINE, [PMID:37393829] [10.1016/j.phymed.2023.154924] |
| 8. Ning Chen, Shenghui Liu, Dan Qin, Dian Guan, Yaqing Chen, Chenjiao Hou, Songyun Zheng, Liqiang Wang, Xiangmei Chen, Wei Chen, Lisheng Zhang. (2023) Fate tracking reveals differences between Reelin+ hepatic stellate cells (HSCs) and Desmin+ HSCs in activation, migration and proliferation. CELL PROLIFERATION, [PMID:37246473] [10.1111/cpr.13500] |
| 9. Zhuo Wei, Chen Juan, Jiang Shilong, Zheng Juyan, Huang Hanxue, Xie Pan, Li Wei, Lei Mengrong, Yin Jiye, Gao Ying, Liu Zhaoqian. (2023) Proteomic profiling of eIF3a conditional knockout mice. Frontiers in Molecular Biosciences, [PMID:37152897] [10.3389/fmolb.2023.1160063] |
| 10. Yan-Mei Li, Xiang Zhou, Xin-Yu Li, Jia-Qi Huang, Zi-Wen Qiu, Ren-Jiang Kong, Ni Yan, Shi-Ying Li, Hong Cheng. (2023) Self-Delivery O2-Ecomonizer to Reverse Antiapoptosis of Hypoxic Tumor for Enhanced Photodynamic Therapy. Advanced Therapeutics, 6 (4): (2200237). [PMID:] [10.1002/adtp.202200237] |
| 11. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, [PMID:36726786] [10.3389/fphar.2022.1089217] |
| 12. Xiaolin Fan, Jilong Guo, Xiaojing Jia, Xingtai Mao, Ying Zhou, Yue Wang, Xuan Guo, Jiashu Shen, Narma Huai, Kailun Zhang, Abida Abdusalam, Hongxia Hu, Hua Zhu, Chengxia Jia, Lan Cheng, Xiqing Li, Zhaobin Zhang. (2022) Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka (Oryzias sinensis): A Study from Laboratory to Field. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:36443945] [10.1021/acs.est.2c05753] |
| 13. Yanfei Zhang, Jun Chen, Huihui Yang, Wen Yin, Chunrong Li, Yuzhi Xu, Si-Yang Liu, Zong Dai, Xiaoyong Zou. (2022) Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells. ANALYTICAL CHEMISTRY, [PMID:35758600] [10.1021/acs.analchem.2c00974] |
| 14. Ning Xu, Mingxing Piao, Kamile Arkin, Lina Ren, Jinyu Zhang, Jiawei Hao, Yuxin Zheng, Qingkun Shang. (2019) Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells. TALANTA, [PMID:31122428] [10.1016/j.talanta.2019.04.021] |
| 15. Zhang Zhaobin, Hu Ying, Guo Jilong, Yu Tong, Sun Libei, Xiao Xuan, Zhu Desheng, Nakanishi Tsuyoshi, Hiromori Youhei, Li Junyu, Fan Xiaolin, Wan Yi, Cheng Siyu, Li Jun, Guo Xuan, Hu Jianying. (2017) Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice. Nature Communications, 8 (1): (1-13). [PMID:28248286] [10.1038/ncomms14585] |
| 16. Xueyao Chen, Yaoming Ge, Wei Shi, Mengting Yang, Qing Zhou, Yang Pan. (2024) Estro-Androgenic Disrupting Effects of Halogenated Disinfection Byproducts: A Comprehensive Evaluation and Comparison. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:39475525] [10.1021/acs.est.4c07223] |
| 17. Yonglin Ruan, Xuehui Li, Gang Zhai, Qiyong Lou, Xia Jin, Jiangyan He, Zhan Yin. (2024) Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (3): (1740). [PMID:38339020] [10.3390/ijms25031740] |
| 18. Zaigang Zhou, Wenjuan Luo, Chunjuan Zheng, Haoxiang Wang, Rui Hu, Hui Deng, Jianliang Shen. (2024) Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy. Acta Pharmaceutica Sinica B, [PMID:39309498] [10.1016/j.apsb.2024.05.028] |
| 19. Zhang Jingjing, Tang Yuyi, Zhang Shan, Xie Zhuxin, Ma Wenrui, Liu Shaowen, Fang Yixuan, Zheng Shufen, Huang Ce, Yan Guoquan, Abudupataer Mieradilijiang, Xin Yue, Zhu Jingqiao, Han Wenjing, Wang Weizhong, Shen Fenglin, Lai Hao, Liu Yang, Ye Dan, Yu Fa-Xing, Xu Yanhui, Pan Cuiping, Wang Chunsheng, Zhu Kai, Zhang Weijia. (2025) Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm. Nature Cardiovascular Research, [PMID:39843801] [10.1038/s44161-024-00606-w] |
| 20. He Hua, Ma Chong, Wei Wei, Wang Haonan, Lai Yutian, Liu Ming, Sun Shenfei, Ma Qing, Lai Jiashuang, Liu Hanxiang, Liu Hanmin, Sun Fei, Lin Xinhua. (2025) Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis. Nature Communications, 16 (1): (1-17). [PMID:39979343] [10.1038/s41467-025-57163-4] |
| 21. Mi Zhou, Jiahuan Hong, Xiaofeng Qiu, Zixian Xiong, Xiaoyong Liu, Zhuan Qin, Zhesi Luo, Qi Chen, Mianjie Lin, Ling Min, Xiaorong Yang, Xinmin Guo, Bin Xu, Jianwen Mao. (2025) Serum-derived extracellular vesicles mediate acquired multidrug resistance of MCF-7 breast cancer cells induced by chemotherapeutic drugs. BIOCHEMICAL PHARMACOLOGY, [PMID:40194604] [10.1016/j.bcp.2025.116923] |
| 22. Zemin Liu, Mingxin Sun, Hongjie Zhou, Liben Cheng, Xiaoli Li, Bin Chen, Chaoqi Wang, Chao Li, Dong Wang, Yan Li, Juan Li, Yonghong Zhang. (2025) Osteocytic FSH inhibition rescues bone mass and boosts fracture healing in ovariectomized mice. LIFE SCIENCES, [PMID:41317982] [10.1016/j.lfs.2025.124121] |
| 23. Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong-Hong Lee. (2025) CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1-Mediated Ubiquitination of NPM1. Advanced Science, [PMID:41114465] [10.1002/advs.202510210] |
| 24. HuiNa Yang, Qiao Peng, Ruonan Shuang, Zihang Guo, Hao Yang, Chang Chen, Weiwei Tao, Li Liu. (2025) Banxia Houpo Decoction reduces lysosomal leakage of prefrontal astrocytes through the OGT-CTSB-NLRP3 pathway to improve depressive-like behaviors. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:41391522] [10.1016/j.jep.2025.121024] |
| 25. Teng Teng, Shaofan Yang, Jin Li, Haoyu Wang, Fengjuan Wu, Yong He, Jihua Fan, Hongwei Shi, Mingzhu Huang, Xiang Zhou, Ying Liu, Mingyue Gong, Chuanyan Yang, Huiquan Wang, Zhenlu Cai, Hongli Li, Kuan Zhang. (2025) Astrocytic α7-nicotinic acetylcholine receptors mediate pain information processing and perception. NEUROBIOLOGY OF DISEASE, [PMID:41453579] [10.1016/j.nbd.2025.107245] |
| 26. Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao. (2026) Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke. Advanced Science, [PMID:41580979] [10.1002/advs.202511482] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →