Thiostrepton - Moligand™, ≥98%, from Streptomyces cyaneus , CAS No.1393-48-2

Name: Thiostrepton - Moligand™, ≥98%, from Streptomyces cyaneus , CAS No.1393-48-2
Brand: Aladdin Scientific
SKU: T419562
Availability: InStock

CAS: 1393-48-2 Cat. No.: T419562 Fórmula: C₇₂H₈₅N₁₉O₁₈S₅ Peso molecular: 1664.89 Número EC: 215-734-9

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Thiostrepton - ≥98%, from Streptomyces cyaneus CAS No(1393-48-2) by Aladdin Scientific

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Disponible para pedir

CALIDAD & PUREZA Moligand™ ? ≥98% from Streptomyces cyaneus

Synonyms

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Hoja de especificaciones

Descripción general Especificaciones Nombres e identificadores Documentación Datos avanzados Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Preguntas frecuentes y artículos Citations of This Product Calculadoras de soluciones Reseñas

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Por qué esta calidad

Moligand™, ≥98%, from Streptomyces cyaneus Moligand™ para flujos de trabajo cromatográficos y analíticos sensibles que requieren una interferencia mínima de la línea base.

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Almacenamiento y envío

Protected from light,Store at -20°C,Argon charged,Desiccated Envío Ice chest + Ice pads. Consulte el COA específico del lote para conocer las especificaciones exactas.

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SDS, COA, ficha técnica y hoja de especificaciones disponibles para descargar. COA específico del lote accesible mediante búsqueda por número de lote.

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Prueba documental

Citado en 3 publicaciones revisadas por pares sobre cromatografía, síntesis orgánica y reacciones de acoplamiento cruzado.

Descripción general

Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1.

Especificaciones

Sinónimos

Especificaciones y pureza

Moligand™, ≥98%, from Streptomyces cyaneus

Mecanismos bioquímicos y fisiológicos

Peptide antibiotic that prevents the binding of elongation factor G (EF-G) and GTP to the 50S ribosomal subunit.Potent Gram-positive antibiotic. Protein synthesis inhibitor. Inhibits FOXM1. Shows antitumor effects in vivo. Enhances cisplatin ( Asc 1398 )

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C,Argon charged,Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

Pubchem Sid

508815436

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/508815436

Sonrisas canónicas

CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C

IUPAC Name

N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(11Z)-37-butan-2-yl-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide

InChIKey

NSFFHOGKXHRQEW-BXVAPQLOSA-N

INCHI

1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-

Isómeros SMILES

CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C/C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C

WGK Alemania

RTECS

XN6300100

Peso molecular

1664.89

Reaxy-Rn

24868543

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24868543&ln=

Documentación

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<<<<<<< HEAD Descargar SDS → ======= Descargar SDS → >>>>>>> release248-p3

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Datos avanzados

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Clase Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Peptides
        Level6 Cyclic peptides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Clase	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Peptides
Direct Parent	Cyclic peptides
Alternative Parents	Pyridinecarboxylic acids Tetrahydropyridines 2,4-disubstituted thiazoles Aralkylamines Imidothiolactones Thiazolines Tertiary alcohols Cyclic carboximidic acids Heteroaromatic compounds Secondary alcohols Amino acids and derivatives Carboxylic acid esters Ketimines Lactones Dialkylamines Polyols Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides Aromatic alcohols
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Cyclic alpha peptide - Pyridine carboxylic acid - 2,4-disubstituted 1,3-thiazole - Tetrahydropyridine - Aralkylamine - Pyridine - Imidothiolactone - Azole - Tertiary alcohol - Heteroaromatic compound - Thiazole - Meta-thiazoline - Cyclic carboximidic acid - Carboxylic acid ester - Ketimine - Lactone - Secondary alcohol - Amino acid or derivatives - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidic acid - Carboximidic acid derivative - Azacycle - Secondary aliphatic amine - Organoheterocyclic compound - Oxacycle - Polyol - Secondary amine - Imine - Aromatic alcohol - Amine - Organonitrogen compound - Organooxygen compound - Alcohol - Organic oxide - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as cyclic peptides. These are compounds containing a cyclic moiety bearing a peptide backbone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

A498 (42825 Activities)

Lot Number	Certificate Type	Fecha	Articulo
J2614727	Certificate of Analysis	Sep 22, 2026	T419562
J2614779	Certificate of Analysis	Sep 22, 2026	T419562
G2603047	Certificate of Analysis	Jul 10, 2026	T419562
G2220165	Certificate of Analysis	May 08, 2026	T419562
G2220166	Certificate of Analysis	May 08, 2026	T419562

Solubilidad	Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water
Sensibilidad	Light sensitive;Moisture sensitive
Punto de fusión (°C)	246-256°C
Peso molecular	1664.900 g/mol
XLogP3	0.600
Hydrogen Bond Donor Count	17
Hydrogen Bond Acceptor Count	31
Rotatable Bond Count	12
Exact Mass	1663.49 Da
Monoisotopic Mass	1663.49 Da
Topological Polar Surface Area	701.000 Å²
Heavy Atom Count	114
Formal Charge	0
Complexity	3940.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	17
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Thiostrepton - Moligand™, ≥98%, from Streptomyces cyaneus , CAS No.1393-48-2

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