Carrier Free, Azide Free, Validated, PBS Only, ≥95%(SDS-PAGE), See COA Azide Free,Carrier Free,PBS Only,Validated para flujos de trabajo cromatográficos y analíticos sensibles que requieren una interferencia mínima de la línea base.
Store at 2-8°C,Do not freeze Envío Wet ice,Do not freeze. Consulte el COA específico del lote para conocer las especificaciones exactas.
SDS, COA, ficha técnica y hoja de especificaciones disponibles para descargar. COA específico del lote accesible mediante búsqueda por número de lote.
Citado en 0 publicaciones revisadas por pares sobre cromatografía, síntesis orgánica y reacciones de acoplamiento cruzado.
Rat anti Mouse TIM 3/CD366 Antibody, Monoclonal (RMT3-23), could be used for Flow, in vivo TIM-3 neutralization, in vitro TIM-3 blocking and so on.
Application:
Flow: Use at an assay dependent concentration.
in vivo TIM-3 neutralization: Use at an assay dependent concentration.
in vitro TIM-3 blocking: Use at an assay dependent concentration.
Protein Function
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock.
TIM3/CD366/PV-1 Rat mAb (Ab131268) - Flow Cytometry
Flow Cytometry analysis of RAW 264.7 cells labelling TIM3/CD366 (red) with TIM3/CD366 Rat mAb (Ab131268) at 0.1 μg/mL for 1 hour at 4°C. SA-PE (rp156150) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, Rat IgG (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
Use at an assay dependent concentration.
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Ver hoja de especificaciones →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 ZJ26F1040067 | Certificate of Analysis | Oct 22, 2026 | Ab131268 |
| ZJ26F1040066 | Certificate of Analysis | Oct 22, 2026 | Ab131268 |
| ZJ26F1040065 | Certificate of Analysis | Oct 22, 2026 | Ab131268 |
| ZJ26F1040064 | Certificate of Analysis | Oct 22, 2026 | Ab131268 |
| ZJ24F1012737 | Certificate of Analysis | May 20, 2026 | Ab131268 |
| ZJ24F1012738 | Certificate of Analysis | May 20, 2026 | Ab131268 |
| ZJ24F1012739 | Certificate of Analysis | May 20, 2026 | Ab131268 |
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