Tinidazole - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.19387-91-8, DNA inhibitor

CAS: 19387-91-8 Cat. No.: T407955 Peso molecular: 247.27 Número EC: 243-014-4 PubChem CID: 5479

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Tinidazole Tinidazole (CP12574) is an anti-parasitic drug.
In vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Tinidazole (CP12574) is an anti-parasitic drug.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

DNA inhibitor

Nombres e identificadores

• Isómeros SMILES: CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C
• RTECS: NI6255000
• PubChem CID: 5479
• Peso molecular: 247.27
• Reaxy-Rn: 618182

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL (162.21 mM); Water: Insoluble; Ethanol: Insoluble
• Punto de fusión (°C): 129 °C

Referencias

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12. Lin Li, Yingying Li, Sijia Zhang, Ting Wang, Xiaohong Hou.  (2022)  Monolithic and compressible MIL-101(Cr)/cellulose aerogel/melamine sponge based microextraction in packed syringe towards trace nitroimidazoles in water samples prior to UPLC-MS/MS analysis.  TALANTA,      [PMID:36122434] [10.1016/j.talanta.2022.123935]

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