Tranexamic Acid (AMCA) - Moligand™, ≥98% , CAS No.1197-18-8

CAS: 1197-18-8 Cat. No.: A111900 Peso molecular: 157.21 Número EC: 214-818-2

GRADE & PURITY Moligand™, ≥98%

Synonyms

tranexamic acid | AMCA | Cyklokapron | trans-4-(Aminomethyl)cyclohexanecarboxylic acid | cyclocapron

Storage

Room temperature

Shipped In

Normal

Descripción general

Inhibits plasmin-induced fibrinolysis

Specifications

Sinónimos

tranexamic acid | AMCA | Cyklokapron | trans-4-(Aminomethyl)cyclohexanecarboxylic acid | cyclocapron

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Antifibrinolytic and plasminogen activation inhibitor. Blocks lysine-binding sites of plasmin and elastase-derived plasminogen fragments (IC 50 = 5 mM).

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Grado

Moligand™

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 488179908
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179908
• Sonrisas canónicas: NC[C@H]1CC[C@@H](CC1)C(O)=O
• IUPAC Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
• InChIKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
• INCHI: 1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
• Isómeros SMILES: C1CC(CCC1CN)C(=O)O
• WGK Alemania: 2
• CAS alternativo: 701-54-2
• Peso molecular: 157.21
• Reaxy-Rn: 2207452
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2207452&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Amino acids
• Alternative Parents: Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Aliphatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as amino acids. These are organic compounds that contain at least one carboxyl group and one amino group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PLG Tclin Plasminogen (0 Activities)

Discover Target: PLG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Soluble in water (167 mg/ml), ethanol (<1 mg/ml at 25°C).Very slightly soluble in ether, DMSO (<1 mg/ml at 25°C), and alcohol.
• Peso molecular: 157.210 g/mol
• XLogP3: -2.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 157.11 Da
• Monoisotopic Mass: 157.11 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 139.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Qiao Yu, Baihai Su, Weifeng Zhao, Changsheng Zhao.  (2022)  Janus Self-Propelled Chitosan-Based Hydrogel Spheres for Rapid Bleeding Control.  Advanced Science,  10  (5): (2205989).  [PMID:36567271] [10.1002/advs.202205989]

2. Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai.  (2022)  Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes.  Bioactive Materials,      [PMID:35415282] [10.1016/j.bioactmat.2022.01.002]

3. Guangxue Chen, Xiaoyuan Guan, Ruixin Xu, Junfei Tian, Fachuang Lu, Minghui He, Jianwen Yang.  (2016)  Thioxanthone dicarboxamide derivatives as one-component photoinitiators for near-UV and visible LED (365–405 nm) induced photopolymerizations.  RSC Advances,  6  (80): (77093-77099).  [PMID:] [10.1039/C6RA13512A]

4. Tao Peng, Xu Lu, Yang Jin, Xicheng Yang, Qian Liu, Chen Chen, Wanting Zhou, Yuting Guo, Yu Zhang, Yankun Gao, Hongjuan Zhang, Hongliang He, Lina Chen.  (2025)  One-stone-four-birds strategy to construct magnetic mesoporous nano-ratio fluorescence sensor for efficient discovery of PSD95-nNOS uncouplers.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.161330]

5. Lin-Xia Liu, Zhi-Kai Liao, Bing-Qi Dong, Shan Jiang, Tie-Chi Lei.  (2024)  Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells.  Annals of Dermatology,      [PMID:38816976] [10.5021/ad.23.108]

6. Yujie Hu, Feiyang Zhang, Jianfeng Zhou, Yi Yang, Deyi Ding, Mingzhang Li, Changming Wang, Boyong Wang, Jinlong Yu, Feng Jiang, Deng-Guang Yu, Hao Shen.  (2025)  Electrospun Tri-Layer Core-Sheath Nanofibrous Coating for Sequential Treatment of Postoperative Complications in Orthopedic Implants.  Small,      [PMID:40898688] [10.1002/smll.202505523]

7. Zizhen Bao, Xiao Ouyang, Yi Liu, Gaoyang Gou, Xiaokang Yao, Yue Zhao, Hang Yin, Yuge Zhang, Shuanma Yan, Zhihua Sun, Zhongfu An, Linyue Liu, Wei Huang, Xiaoping Ouyang.  (2026)  Bright 2D Polar Perovskite Scintillator with Ultrafast Decay by Suppressing Free Carrier Recombination.  ADVANCED MATERIALS,      [PMID:41631384] [10.1002/adma.202517639]