Valproic acid (sodium) , CAS No.1069-66-5

CAS: 1069-66-5 Cat. No.: V1372220-GMP Peso molecular: 166.2 Número EC: 213-961-8 PubChem CID: 16760703

Storage

Room temperature

Shipped In

Normal

Descripción general

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

Specifications

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Nombres e identificadores

• Sonrisas canónicas: CCCC(CCC)C(=O)[O-].[Na+]
• IUPAC Name: sodium;2-propylpentanoate
• InChIKey: AEQFSUDEHCCHBT-UHFFFAOYSA-M
• INCHI: 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
• Isómeros SMILES: CCCC(CCC)C(=O)[O-].[Na+]
• WGK Alemania: 3
• RTECS: YV7876000
• PubChem CID: 16760703
• Peso molecular: 166.2
• Reaxy-Rn: 4212221

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acids and conjugates
• Alternative Parents: Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid - Carboxylic acid salt - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic sodium salt - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as fatty acids and conjugates. These are aliphatic monocarboxylic acids with a saturated or unsaturated aliphatic tail (with at least 4 Carbon atoms).
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Referencias

1. Yuan Yuyang, Li Tianyu, Ye Zhichao, Feng Yuyao, Chen Zhe, Wang Yusen, Sun Yiqiao, Wu Haoyu, Yang Zhaodong, Wang Yifan, Zhang Yiran, Huang Liquan, Liang Bo.  (2022)  A One-Step Electropolymerized Biomimetic Polypyrrole Membrane-Based Electrochemical Sensor for Selective Detection of Valproate.  Frontiers in Bioengineering and Biotechnology,      [PMID:35242753] [10.3389/fbioe.2022.851692]

2. Guo Qing, Gan Jun, Wang En-ze, Wei Yu-ming, Xu Jie, Xu Yun, Zhang Fei-fei, Cui Meng, Jia Meng-xing, Kong Ming-jian, Tang Qiong-yao, Zhang Zhe.  (2025)  Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model.  ACTA PHARMACOLOGICA SINICA,      [PMID:39870847] [10.1038/s41401-024-01457-8]

3. Yingjun Xu, Yiming Han, Li Liu, Shanshan Han, Shibiao Zou, Bo Cheng, Fengbang Wang, Xunwei Xie, Yong Liang, Maoyong Song, Shaochen Pang.  (2024)  Highly sensitive response to the toxicity of environmental chemicals in transparent casper zebrafish.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39032757] [10.1016/j.scitotenv.2024.174865]

4. Hongshan Li, Rongqian Mo, Jiayu Yue, Rongrong Cheng, Dianyu Li, Yusuf M. Idres, Yanmei Yang, Yanqiao Wen, Xiangrong Li, Ruofei Feng.  (2024)  Sodium valproate promotes low metabolism and high protein expression in CHO-engineered cell lines.  BIOCHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.bej.2024.109362]

5. Yuwei Zhu, Wenbo Gao, Jianlin Zheng, Ye Bai, Xinyu Tian, Tengjin Huang, Zebin Lu, De Dong, Anqi Zhang, Changyou Guo, Zhiwei Huang.  (2025)  Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation.  IMMUNITY,      [PMID:40334665] [10.1016/j.immuni.2025.04.012]

6. Yang Zhao, Feiya Zhu, Jiayu Xie, Yiting Wang, Motlalepula Matsabisa, Minke Tang.  (2025)  Panax notoginseng Flower Extract Attenuates Pentylenetetrazole-Induced Epilepsy by Restoring Glutamate Homeostasis.  Brain Sciences,  15  (10): (1110).  [PMID:41154204] [10.3390/brainsci15101110]

7. Xin Gao, Xinjia Li, Yuanteng Zheng, Lijie Xia, Haonan Li, Yuqing Li, Attila Sik, Kechun Liu, Meng Jin.  (2025)  Rapid antiepileptic activity identification of isopimpinellin using a multi-model of epilepsy based on behavior-biomarker-BBB screening pipeline.  PHYTOMEDICINE,      [PMID:41351986] [10.1016/j.phymed.2025.157636]

8. Xiangxi Meng, Yumo Tian, Sen Hu, Lili Wang, Yuxian Zhong, Kui Sun, Minghua Du.  (2026)  The protective effect of sodium valproate on rats with severe scald combined with seawater immersion.  EUROPEAN JOURNAL OF MEDICAL RESEARCH,      [PMID:41709307] [10.1186/s40001-026-04043-2]