Vancomicina HCL - PharmPure™, USP, potencia: ≥900 ug por mg , CAS No.1404-93-9

CAS: 1404-93-9 Cat. No.: V105495 Fórmula: C₆₆H₇₆Cl₃N₉O₂₄ Peso molecular: 1485.71 Beilstein Registry Number: 3704657 Número EC: 604-193-8 PubChem CID: 6420023

CALIDAD & PUREZA PharmPure™, USP, potency: ≥900 ug per mg

Synonyms

VANCOMYCIN HYDROCHLORIDE (EP MONOGRAPH) | EN300-26256009 | Vancocin hydrochloride in plastic container | CCG-222571 | VANCOMYCIN MONOHYDROCHLORIDE [MI] | VANCOMYCINHYDROCHLORIDE | VANCOMYCIN HYDROCHLORIDE [ORANGE BOOK] | UNII-71WO621TJD | DTXSID90891868 |

Storage

Conservar a 2-8°C,cargado con argón

Shipped In

Hielo húmedo

Descripción general

La vancomicina, procedente de Streptomyces orientalis, se utiliza para el tratamiento de infecciones graves o severas causadas por cepas susceptibles de estafilococos resistentes a la meticilina (resistentes a los β-lactámicos). Se utiliza para bloquear la biosíntesis de la pared celular bacteriana a nivel de la biosíntesis del peptidoglicano. Se ha estudiado el uso excesivo de la vancomicina, lo que ha dado lugar a directrices recomendadas.

Especificaciones

Sinónimos

VANCOMYCIN HYDROCHLORIDE (EP MONOGRAPH) | EN300-26256009 | Vancocin hydrochloride in plastic container | CCG-222571 | VANCOMYCIN MONOHYDROCHLORIDE [MI] | VANCOMYCINHYDROCHLORIDE | VANCOMYCIN HYDROCHLORIDE [ORANGE BOOK] | UNII-71WO621TJD | DTXSID90891868 |

Especificaciones y pureza

PharmPure™, USP, potencia: ≥900 ug por mg

Mecanismos bioquímicos y fisiológicos

La vancomicina es un antibiótico glucopéptido que bloquea la biosíntesis de la pared celular bacteriana a nivel de la biosíntesis del peptidoglicano. Inhibe la incorporación de las moléculas terminales D-alanil-D-alanina de los péptidos NAM/NAG. Es eficaz

Condiciones de almacenamiento de almacenamiento

Conservar a 2-8°C,cargado con argón

Enviado en

Hielo húmedo

Grado

PharmPure™, USP

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. No obstante, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Nombres e identificadores

Pubchem Sid

508815032

Sonrisas canónicas

CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl

IUPAC Name

(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid;hydrochloride

InChIKey

LCTORFDMHNKUSG-XTTLPDOESA-N

INCHI

1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

Isómeros SMILES

C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl

WGK Alemania

2

RTECS

YW4380000

PubChem CID

6420023

Peso molecular

1485.71

Beilstein

3704657

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Cyclic peptides Aminoglycosides Phenolic glycosides Leucine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Disaccharides Diarylethers O-glycosyl compounds 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Aryl chlorides N-acyl amines Oxanes Secondary carboxylic acid amides 1,2-aminoalcohols Primary carboxylic acid amides Secondary alcohols Lactams Amino acids Polyols Oxacyclic compounds Acetals Monocarboxylic acids and derivatives Azacyclic compounds Carboxylic acids Dialkylamines Primary alcohols Organopnictogen compounds Carbonyl compounds Organochlorides Monoalkylamines Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-oligopeptide - Cyclic alpha peptide - Aminoglycoside core - Phenolic glycoside - Leucine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - O-glycosyl compound - Diaryl ether - Disaccharide - Glycosyl compound - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Amino saccharide - 1-hydroxy-4-unsubstituted benzenoid - Aryl halide - Fatty acyl - Benzenoid - Oxane - Fatty amide - Aryl chloride - N-acyl-amine - Primary carboxylic acid amide - Secondary alcohol - Secondary carboxylic acid amide - Carboxamide group - Lactam - Amino acid or derivatives - Amino acid - 1,2-aminoalcohol - Acetal - Oxacycle - Azacycle - Organoheterocyclic compound - Carboxylic acid - Secondary amine - Secondary aliphatic amine - Ether - Polyol - Monocarboxylic acid or derivatives - Organohalogen compound - Amine - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Hydrochloride - Alcohol - Primary amine - Primary alcohol - Hydrocarbon derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organochloride - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
• Sensibilidad: Hygroscopic
• Peso molecular: 1485.700 g/mol
• Hydrogen Bond Donor Count: 20
• Hydrogen Bond Acceptor Count: 26
• Rotatable Bond Count: 13
• Exact Mass: 1483.41 Da
• Monoisotopic Mass: 1483.41 Da
• Topological Polar Surface Area: 530.000 Ų
• Heavy Atom Count: 102
• Formal Charge: 0
• Complexity: 2960.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 18
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3