Y-27632 - Moligand™, ≥98% , Inhibitor of protein kinase C epsilon;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2, CAS No.146986-50-7, Inhibitor of protein kinase C epsilon;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2

CAS: 146986-50-7 Cat. No.: Y125330 Peso molecular: 247.34 Número EC: 620-446-5 PubChem CID: 448042

GRADE & PURITY Moligand™, ≥98%

Synonyms

BDBM86729 | Bio2_000937 | NCGC00092276-06 | HY-10071 | Y27632 | y-27632 | 4-[(1R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide | HMS1792N15 | HMS3403N15 | trans-4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexanecarboxamide | CCG-204428 | NCGC00092276-10

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

BDBM86729 | Bio2_000937 | NCGC00092276-06 | HY-10071 | Y27632 | y-27632 | 4-[(1R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide | HMS1792N15 | HMS3403N15 | trans-4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexanecarboxamide | CCG-204428 | NCGC00092276-10

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of protein kinase C epsilon;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504758873
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758873
• Sonrisas canónicas: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
• IUPAC Name: 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
• InChIKey: IYOZTVGMEWJPKR-VOMCLLRMSA-N
• INCHI: 1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1
• Isómeros SMILES: C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
• PubChem CID: 448042
• Peso molecular: 247.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Clase Organonitrogen compounds
      • Subclass N-arylamides

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Clase: Organonitrogen compounds
• Subclass: N-arylamides
• Intermediate Tree Nodes: Not available
• Direct Parent: N-arylamides
• Alternative Parents: Pyridines and derivatives Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: N-arylamide - Pyridine - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Organopnictogen compound - Organic oxygen compound - Primary amine - Organooxygen compound - Primary aliphatic amine - Amine - Carbonyl group - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as n-arylamides. These are organic compounds that contain a carboxamide group that is N-linked to a aryl group. They have the generic structure RC(=O)N(R')H, R = organyl group and R'= aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ROCK2 Tclin Rho-associated protein kinase 2 (0 Activities)

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK1 Tclin Rho-associated protein kinase 1 (1 Activities)

Discover Target: ROCK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKN2 Tchem Serine/threonine-protein kinase N2 (1 Activities)

Discover Target: PKN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon type (1 Activities)

Discover Target: PRKCE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: 49 mg/mL(198.11 mM) in DMSO；Insoluble in Water；49 mg/mL (198.11 mM) in Ethanol
• Sensibilidad: light sensitive
• Peso molecular: 247.340 g/mol
• XLogP3: 0.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 247.168 Da
• Monoisotopic Mass: 247.168 Da
• Topological Polar Surface Area: 68.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 268.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang.  (2025)  ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  57  (1): (14).  [PMID:41201025] [10.3892/ijmm.2025.5685]