YC-1 - Moligand™, ≥98% , Activator of Guanylyl cyclase; α 1β 1;Activator of Guanylyl cyclase; α 2β 1, CAS No.170632-47-0, Activator of Guanylyl cyclase; α 1β 1;Activator of Guanylyl cyclase; α 2β 1

CAS: 170632-47-0 Cat. No.: Y274733 Peso molecular: 304.34 PubChem CID: 5712

GRADE & PURITY Moligand™, ≥98%

Synonyms

3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole | A907557 | YC1 | yc-1 | [5-[1-(phenylmethyl)indazol-3-yl]furan-2-yl]methanol | GTPL5291 | KBio3_000654 | LIFICIGUAT [WHO-DD] | UNII-515CC1WPTE | IDI1_002079 | 1-Benzyl-3-(5'-hydroxymethyl-2-furyl)indazole |

Storage

Conservar a -20°C,Desecado

Shipped In

Hielera + almohadillas de hielo

Descripción general

YC-1 se ha utilizado como inhibidor del factor 1α inducible por hipoxia (HIF-1α)

para reducir la expresión de Jagged1 inducida por la hipoxia en cardiomiocitos (CM) para estudiar su efecto sobre la expansión de progenitores y el fenotipo de células CD34+ y de población lateral (SP) y sobre la tasa de proliferación de células con capacidad para formar unidades formadoras de colonias a largo plazo para estudiar su efecto sobre la regulación de la esfingosina 1-fosfato (S1P) unida a albúmina inducida por la expresión del inhibidor del activador del plasminógeno 1 (PAI-1) mediante la activación de la vía Rho/proteína cinasa asociada a Rho (ROCK).

Specifications

Sinónimos

3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole | A907557 | YC1 | yc-1 | [5-[1-(phenylmethyl)indazol-3-yl]furan-2-yl]methanol | GTPL5291 | KBio3_000654 | LIFICIGUAT [WHO-DD] | UNII-515CC1WPTE | IDI1_002079 | 1-Benzyl-3-(5'-hydroxymethyl-2-furyl)indazole |

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Activador soluble reversible de la guanilil ciclasa (EC 50 = 18, 6 μM). Independiente del NO. Induce un aumento del GMPc in vitro dependiente de la concentración . Reduce la permeabilidad de la barrera hematoencefálica mediante la inhibición de HIF-1 in vi

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C, Desecado

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

ACTIVATOR

Mecanismo de acción

Activator of Guanylyl cyclase; α 1β 1;Activator of Guanylyl cyclase; α 2β 1

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504750929
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750929
• Sonrisas canónicas: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
• IUPAC Name: [5-(1-benzylindazol-3-yl)furan-2-yl]methanol
• InChIKey: OQQVFCKUDYMWGV-UHFFFAOYSA-N
• INCHI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• Isómeros SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
• PubChem CID: 5712
• Peso molecular: 304.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzopyrazoles
      • Subclass Indazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzopyrazoles
• Subclass: Indazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Indazoles
• Alternative Parents: Benzene and substituted derivatives Pyrazoles Heteroaromatic compounds Furans Oxacyclic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzopyrazole - Indazole - Monocyclic benzene moiety - Benzenoid - Azole - Furan - Pyrazole - Heteroaromatic compound - Azacycle - Oxacycle - Aromatic alcohol - Alcohol - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as indazoles. These are compounds containing an indazole, which is structurally characterized by a pyrazole fused to a benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

GUCY1A1 Tclin Guanylate cyclase soluble subunit alpha-1 (0 Activities)

Discover Target: GUCY1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GUCY1A2 Tclin Guanylate cyclase soluble subunit alpha-2 (0 Activities)

Discover Target: GUCY1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GUCY1B1 Tclin Guanylate cyclase soluble subunit beta-1 (0 Activities)

Discover Target: GUCY1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

Discover Target: PDE5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV1 Tclin Vanilloid receptor (8273 Activities)

Discover Target: TRPV1

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CACNA1B Tclin Voltage-gated N-type calcium channel alpha-1B subunit (743 Activities)

Discover Target: CACNA1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARSA Tbio Cerebroside-sulfatase (655 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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AGS (1999 Activities)

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COLO 205 (50209 Activities)

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Detroit 551 (346 Activities)

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HL-60 (67320 Activities)

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MCF7 (126967 Activities)

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PC-3 (62116 Activities)

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SK-OV-3 (52876 Activities)

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A549 (127892 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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HepG2 (196354 Activities)

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A2780 (11979 Activities)

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HeLa (62764 Activities)

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NCI-H226 (44470 Activities)

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DMS-114 (15429 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

Discover Target: HIF1A

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

Discover Target: HSD17B10

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POLI Tchem DNA polymerase iota (116820 Activities)

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Liver microsomes (16955 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNCA Tchem Alpha-synuclein (10960 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NPC1 Tchem Niemann-Pick C1 protein (18985 Activities)

Discover Target: NPC1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Saccharomyces cerevisiae (19171 Activities)

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Plasmodium falciparum (966862 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

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FTL Ferritin light chain (43324 Activities)

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nfo Endonuclease 4 (425 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

Discover Target: NS1

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in ethanol to 50 mM and in DMSO to 50 mM
• Peso molecular: 304.300 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 304.121 Da
• Monoisotopic Mass: 304.121 Da
• Topological Polar Surface Area: 51.200 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 386.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Huijuan Ma, Qi Shu, Peiyao Wang, Ruilin Qin, Sijia Li, Huan Xu.  (2023)  Formaldehyde exacerbates asthma in mice through the potentiation of HIF-1α-mediated pro-inflammatory responses in pulmonary macrophages.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:37105513] [10.1016/j.cbi.2023.110514]

2. Panpan Xue, Huilan Zhuang, Sijie Shao, Tingjie Bai, Xuemei Zeng, Shuangqian Yan.  (2024)  Engineering Biodegradable Hollow Silica/Iron Composite Nanozymes for Breast Tumor Treatment through Activation of the “Ferroptosis Storm”.  ACS Nano,      [PMID:39226614] [10.1021/acsnano.4c08574]

3. Jing Sun, Zhengtian Zhao, Jiaqi Lu, Wen An, Yiming Zhang, Wei Li, Li Yang.  (2024)  The Tumor Microenvironment Mediates the HIF-1α/PD-L1 Pathway to Promote Immune Escape in Colorectal Cancer.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  25  (7): (3735).  [PMID:38612546] [10.3390/ijms25073735]

4. Tang Pingfei, Wu Yueming, Tan Lin, Zhang Chao, Qin Liping, Wu Dajun.  (2025)  ZNF454-FSTL3 axis inhibits colorectal cancer progression by inhibiting HIF-1α-mediated glycolysis in hypoxia.  Journal of Gastrointestinal Oncology,  16  (6): (2703).  [PMID:41522747] [10.21037/jgo-2025-326]