Alprostadil - Moligand™, 10mM in DMSO , Prostanoid EP2 receptor agonist, CAS No.745-65-3, Prostanoid EP2 receptor agonist

CAS: 745-65-3 Cat. No.: A409017 분자식: C₂₀H₃₄O₅ 분자량: 354.48 Beilstein Registry Number: 5294062 EC 번호: 212-017-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Prostaglandin-E1, PGE1, Edex, Muse, Liprostin | 11,15-dihydroxy-9-oxo-, (11α,13E,15S)-prost-13-en-1-oic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Alprostadil Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
In vitro

In vivo

Cell Data

cell lines：Human bronchial fibroblast

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

동의어

Prostaglandin-E1, PGE1, Edex, Muse, Liprostin | 11,15-dihydroxy-9-oxo-, (11α,13E,15S)-prost-13-en-1-oic acid

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

ACTIVATOR, AGONIST

작동 메커니즘

Prostanoid EP2 receptor agonist

제품 특성

• ALogP: 3.2

이름과 식별자

• 이성체 SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O
• WGK 독일: 3
• RTECS: GY4569800
• UN 번호: 2811
• 포장 그룹: III
• 분자량: 354.48
• Beilstein: 5294062
• Reaxy-Rn: 2704847
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2704847&ln=

관련 대상(인간)

CATSPER4 Tchem Cation channel sperm-associated protein 4 (1 Activities)

Discover Target: CATSPER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER1 Tchem Cation channel sperm-associated protein 1 (1 Activities)

Discover Target: CATSPER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER3 Tchem Cation channel sperm-associated protein 3 (1 Activities)

Discover Target: CATSPER3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER2 Tchem Cation channel sperm-associated protein 2 (1 Activities)

Discover Target: CATSPER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype (3 Activities)

Discover Target: PTGER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor (1 Activities)

Discover Target: PTGDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype (4 Activities)

Discover Target: PTGER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER1 Tclin Prostaglandin E2 receptor EP1 subtype (3 Activities)

Discover Target: PTGER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGIR Tclin Prostacyclin receptor (2 Activities)

Discover Target: PTGIR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype (3 Activities)

Discover Target: PTGER3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 끓는점(°C): 529.28 °C/760 mmHg
• 녹는점(°C): 114-115°C

참고 문헌

1. Ning Yu, Shule Zhang, Rui Fang, Yingxin Zhang, Xi Xu, Lijuan Cao, Jianfa Zhang.  (2025)  Selective thrombolysis through fibrin network destabilization: An unrecognized heparin analog mechanism.  PHARMACOLOGICAL RESEARCH,      [PMID:40976458] [10.1016/j.phrs.2025.107961]

2. Xiaoying Wang, Xiaoxing Fang, Xuewei Li, Hejiang Cheng, Hua Jiang, Ji Zheng.  (2025)  A colorimetric assay developed for the evaluation of tumor cell-platelet interaction and drug intervention.  TALANTA,      [PMID:40946479] [10.1016/j.talanta.2025.128836]

3. Zhang Xiaoning, Liang Min, Song Dandan, Huang Rongzu, Chen Chen, Liu Xiaojun, Chen Houyang, Wang Qingxin, Sun Xiaoli, Song Jian, Zhang Jiali, Kang Hang, Zeng Xuhui.  (2024)  Both protein and non-protein components in extracellular vesicles of human seminal plasma improve human sperm function via CatSper-mediated calcium signaling.  HUMAN REPRODUCTION,      [PMID:38335261] [10.1093/humrep/deae018]

4. Lili Wang, Yunqian Li, Ran Guo, Shanshan Li, Anqi Chang, Zhixiang Zhu, Pengfei Tu.  (2019)  Optimized bioluminescence analysis of adenosine triphosphate (ATP) released by platelets and its application in the high throughput screening of platelet inhibitors.  PLoS One,  14  (10): (e0223096).  [PMID:31600247] [10.1371/journal.pone.0223096]

5. Yue Li, Yayue Zhang, Xuran Ding, Taotao Zou, Hu Li, Ke Xu, Cheng Su, Yuting Wang, Ziming Zhao, Yuan He.  (2025)  Tailored platelet biomimetic delivery platform for targeted therapy of inflammatory bowel disease.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.166357]

6. Hao Li, Xiaowei Xie, Yu Zhang, Xiaopeng Han, Ting Shi, Jiayin Li, Wanyu Chen, Qin Wei, Hong Pan, Shuxian Xu, Qiuyu Chen, Lifang Yin, Chao Qin.  (2025)  MOF-Engineered Platelet-Mimicking Nanocarrier-Encapsulated Cascade Enzymes for ROS Scavenging and Anti-Inflammation in Cerebral Ischemia–Reperfusion Injury.  Pharmaceutics,  17  (11): (1478).  [PMID:41304816] [10.3390/pharmaceutics17111478]

7. Tianjiao Hao, Bin Gao, Yuanyuan Zhou, Chang Liu, Chuanjiang Ran, Binghua Chang, Wei You, Qiyue Wang, Jun Ye, Yan Shen.  (2026)  A spatiotemporal selective bioinspired hybrid system engineered for preventing post-thrombolysis recurrence by inhibiting the ferroptosis pathway and reprogramming macrophages.  Acta Pharmaceutica Sinica B,      [PMID:] [10.1016/j.apsb.2026.01.014]