AMN082 free base - ≥98% , CAS No.83027-13-8

CAS: 83027-13-8 Cat. No.: A336629 분자식: C₂₈H₂₈N₂ 분자량: 392.54 PubChem CID: 11698390

GRADE & PURITY ≥98%

Synonyms

N,N'-dibenzhydryl-1,2-ethanediamine dihydrochloride | N,N/'-dibenzhydrylethane-1,2-diamine;dihydrochloride | N,N'-dibenzhydrylethylenediamine dihydrochloride | AMN 082 | N,N inverted exclamation marka-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

개요

AMN082 Dihydrochloride is a potent and selective agonist at mGluR-7, acting at an allosteric site. mGluR-7 is a metabotropic glutamate receptor 7. AMN082 has been shown to promote the proliferation and differentiation of neural progenitor cells.

Product description：

AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects

Specifications

동의어

N,N'-dibenzhydryl-1,2-ethanediamine dihydrochloride | N,N/'-dibenzhydrylethane-1,2-diamine;dihydrochloride | N,N'-dibenzhydrylethylenediamine dihydrochloride | AMN 082 | N,N inverted exclamation marka-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride

사양 및 순도

≥98%

보관 조건

Store at 2-8°C,Protected from light,Desiccated

배송

Wet ice

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작업 유형

AGONIST

순수함

≥98%

제품 특성

• pKa: pKₐ: 8.38

이름과 식별자

• Pubchem Sid: 508810310
• 정식 스마일: C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
• IUPAC Name: N,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride
• InChIKey: YRQCDCNQANSUPB-UHFFFAOYSA-N
• INCHI: 1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
• 이성체 SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
• WGK 독일: 3
• PubChem CID: 11698390
• 분자량: 392.54

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Aralkylamines Dialkylamines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Diphenylmethane - Aralkylamine - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic homomonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)

Discover Target: RUNX1

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관련 대상(비인간)

lef Anthrax lethal factor (7585 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in DMSO (10 mg/ml), 100% ethanol, methanol (10 mM), and water.
• 감도: light sensitive
• 끓는점(°C): 533.7° C at 760 mmHg (Predicted)
• 분자량: 465.500 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 464.179 Da
• Monoisotopic Mass: 464.179 Da
• Topological Polar Surface Area: 24.100 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 362.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3