아트로핀 - 몰리건드™, ≥99% , Muscarinic acetylcholine receptor M2 antagonist, CAS No.51-55-8, Muscarinic acetylcholine receptor M2 antagonist

CAS: 51-55-8 Cat. No.: A135946 분자식: C17H23NO3 분자량: 289.37 Beilstein Registry Number: 91260 EC 번호: 200-104-8
주문 가능
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
Synonyms
(1R,3r,5S)-8-메틸-8-아자비클로[3.2.1]옥탄-3-일 3-하이드록시-2-페닐프로파노에이트 | 알파-(하이드록시메틸)벤젠아세트산 8-메틸-8-아자비클로(3.2.1)옥탄-3-일 에스테르 | 아트로핀, >=95.0% (NT) | InChI=1/C11H8Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15
Storage
2-8°C에서 보관, 빛으로부터 보호, 아르곤 충전
Shipped In
젖은 얼음
★
Size
USA
독일 (EU)*
Price
Qty
250mg
A135946-250mg
주문제작 · 8~12주
US$33.90
1g
A135946-1g
3 재고 있음
—
US$91.90
5g
A135946-5g
5 재고 있음
—
US$321.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

몰리건드™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

2-8°C에서 보관, 빛으로부터 보호, 아르곤 충전 Ships 젖은 얼음 Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

동의어
(1R,3r,5S)-8-메틸-8-아자비클로[3.2.1]옥탄-3-일 3-하이드록시-2-페닐프로파노에이트 | 알파-(하이드록시메틸)벤젠아세트산 8-메틸-8-아자비클로(3.2.1)옥탄-3-일 에스테르 | 아트로핀, >=95.0% (NT) | InChI=1/C11H8Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15
사양 및 순도
몰리건드™, ≥99%
생화학 및 생리적 메커니즘
중추 및 말초 무스카린 아세틸콜린 수용체에서의 경쟁적 비선택적 길항제.강력하고 경쟁적인 비선택적 mAChR 길항제(IC 50 = 2.5 nM). 산동증을 유발합니다. 생체 내에서 항무스카린 및 항콜린 효과를 나타냅니다. 경구 작용
보관 조건
2-8°C에서 보관, 빛으로부터 보호, 아르곤 충전
배송
젖은 얼음
등급
Moligand™
작업 유형
ANTAGONIST
작동 메커니즘
Muscarinic acetylcholine receptor M2 antagonist
참고
가능하면 당일에 용액을 준비하여 사용하는 것이 좋습니다. 하지만 미리 원액을 만들어야 하는 경우에는 -20°C에서 단단히 밀봉된 바이알에 소량씩 보관하는 것이 좋습니다. 일반적으로 최대 한 달 동안 사용할 수 있습니다. 사용하기 전에 바이알을 열기 전에 제품을 실온에서 최소 1시간 동안 평형을 이루도록 하는 것이 좋습니다. 독성이 있는 경우 자세한 내용은 SDS를 참조하세요. 용해도, 사용법 및 취급에 대한 추가 정보가 필요하신가요? 자세한 내용은 자주 묻는 질문(FAQ) 페이지를 참조하세요.
순수함
≥99%
제품 특성
ALogP1.8
이름과 식별자
Pubchem Sid504757676
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504757676
정식 스마일CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
IUPAC Name[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
InChIKeyRKUNBYITZUJHSG-PJPHBNEVSA-N
INCHI1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
이성체 SMILES CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
WGK 독일 3
RTECS CK0700000
분자량 289.37
Beilstein 91260
Reaxy-Rn 91256
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=91256&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassAlkaloids and derivatives
분류Tropane alkaloids
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentTropane alkaloids
Alternative Parents Beta hydroxy acids and derivatives  Piperidines  N-alkylpyrrolidines  Benzene and substituted derivatives  Trialkylamines  Carboxylic acid esters  Amino acids and derivatives  Monocarboxylic acids and derivatives  Azacyclic compounds  Primary alcohols  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Tropane alkaloid - Beta-hydroxy acid - Monocyclic benzene moiety - Hydroxy acid - Piperidine - Benzenoid - N-alkylpyrrolidine - Pyrrolidine - Amino acid or derivatives - Carboxylic acid ester - Tertiary aliphatic amine - Tertiary amine - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Alcohol - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organic nitrogen compound - Primary alcohol - Aromatic heteropolycyclic compound
설명This compound belongs to the class of organic compounds known as tropane alkaloids. These are organic compounds containing the nitrogenous bicyclic alkaloid parent N-Methyl-8-azabicyclo[3.2.1]octane.
External Descriptors Not available
3D 구조
상호 작용 화학 구조 모델





관련 대상(인간)
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (9 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (8 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (21 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (10 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2A Tclin Alpha-2A adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate Type날짜항목
G2606125Certificate of AnalysisJul 10, 2026 A135946
L2511069Certificate of AnalysisDec 17, 2025 A135946
L2307231Certificate of AnalysisSep 09, 2025 A135946
L2307240Certificate of AnalysisSep 09, 2025 A135946
L2307242Certificate of AnalysisSep 09, 2025 A135946
L2307243Certificate of AnalysisSep 09, 2025 A135946
C2526028Certificate of AnalysisDec 12, 2023 A135946
L2307239Certificate of AnalysisDec 12, 2023 A135946
L2307241Certificate of AnalysisDec 12, 2023 A135946
K2301123Certificate of AnalysisOct 21, 2023 A135946
K2301125Certificate of AnalysisOct 21, 2023 A135946
K2301136Certificate of AnalysisOct 21, 2023 A135946
L2418092Certificate of AnalysisOct 21, 2023 A135946

Show more ⌵

화학 및 물리적 특성
용해성Soluble in dilute aqueous acid, ethanol.
감도Light & Air sensitive.
분자량289.400 g/mol
XLogP31.800
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass289.168 Da
Monoisotopic Mass289.168 Da
Topological Polar Surface Area49.800 Ų
Heavy Atom Count21
Formal Charge0
Complexity353.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
자주 묻는 질문과 기사
Citations of This Product
참고 문헌
1. Dianfa Zhao, Jie Liu, Yunshan Zhou, Lijuan Zhang, Yuxu Zhong, Yang Yang, Baoquan Zhao, Mengru Yang, Yong’an Wang.  (2023)  Penetrating the Blood–Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH2(Fe).  ACS Applied Materials & Interfaces,      [PMID:36867458] [10.1021/acsami.2c18929]
2. Dianfa Zhao, Jie Liu, Lijuan Zhang, Yunshan Zhou, Yuxu Zhong, Yang Yang, Chengcheng Huang, Yong’an Wang.  (2021)  Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.  INORGANIC CHEMISTRY,      [PMID:34969248] [10.1021/acs.inorgchem.1c03227]
3. Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang, Xinfeng Zhao.  (2021)  Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:34365202] [10.1016/j.chroma.2021.462443]
4. Si Tang, Jing Zhu, Dong Zhao, Huaheng Mo, Zhaofu Zeng, Mengqing Xiong, Minglin Dong, Ke Hu.  (2020)  Effects of the excitation or inhibition of basal forebrain cholinergic neurons on cognitive ability in mice exposed to chronic intermittent hypoxia.  BRAIN RESEARCH BULLETIN,      [PMID:32905806] [10.1016/j.brainresbull.2020.08.027]
5. Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu.  (2020)  Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway.  MEDIATORS OF INFLAMMATION,      [PMID:32508523] [10.1155/2020/2929163]
6. Ke Chen, Yilei Zhao, Ting Liu, Zhaohao Su, Huiliang Yu, Leanne Lai Hang Chan, Tiejun Liu, Dezhong Yao.  (2020)  Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex.  Jove-Journal of Visualized Experiments,      [PMID:32090984] [10.3791/60600]
7. Lianfang Chen, Junjie Ou, Hongwei Wang, Zhongshan Liu, Mingliang Ye, Hanfa Zou.  (2016)  Tailor-Made Stable Zr(IV)-Based Metal–Organic Frameworks for Laser Desorption/Ionization Mass Spectrometry Analysis of Small Molecules and Simultaneous Enrichment of Phosphopeptides.  ACS Applied Materials & Interfaces,      [PMID:27427857] [10.1021/acsami.6b06225]
8. Ji-Hong Chen, Qian Zhang, Yuanjie Yu, Kongling Li, Hong Liao, Longying Jiang, Lu Hong, Xiaohui Du, Xinghai Hu, Sifeng Chen, Sheng Yin, Qingmin Gao, Xiangdong Yin, Hesheng Luo, Jan D. Huizinga.  (2013)  Neurogenic and Myogenic Properties of Pan-Colonic Motor Patterns and Their Spatiotemporal Organization in Rats.  PLoS One,  8  (4): (e60474).  [PMID:23577116] [10.1371/journal.pone.0060474]
9. Shuo Li, Alhamdu Adamu, Yucai Ye, Fankai Gao, Rulin Mi, Guofang Xue, Zhaojun Wang.  (2024)  (+)-Borneol inhibits neuroinflammation and M1 phenotype polarization of microglia in epileptogenesis through the TLR4-NFκB signaling pathway.  Frontiers in Neuroscience,      [PMID:39605791] [10.3389/fnins.2024.1497102]
10. Cunzheng Zhang, Yuzhu Chen, Ruqiao Duan, Yiming Zhang, Haonan Zheng, Jindong Zhang, Tao Zhang, Jingxian Xu, Kailong Li, Fei Pei, Liping Duan.  (2025)  Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41–GDNF/RET/SOX10 signaling pathway.  iMeta,      [PMID:40236770] [10.1002/imt2.70012]
11. Huang Xiaomin, Wang Ting, Wang Ludan, Sun Yantao, Zhang Ziru, Zhang Yajun.  (2024)  Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products.  BMC Chemistry,  18  (1): (1-15).  [PMID:38702791] [10.1186/s13065-024-01198-z]
12. Cai-Feng Zhang, Xiao-Li Zhang, Jun-Hui Zhang, Yue Zhang, Jin Song, Jin-Xia Zhu.  (2026)  Activation of the dopamine D2 receptor enhances colonic motility via disinhibition of somatostatinergic signalling in rodents.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:] [10.1016/j.ejphar.2026.179278]
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