Name: AZD2932 - ≥98% , CAS No.883986-34-3
SKU: A413703
Availability: InStock

AZD2932 - ≥98% , CAS No.883986-34-3

CAS: 883986-34-3 Cat. No.: A413703 분자식: C₂₄H₂₅N₅O₄ 분자량: 447.49

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AZD2932 - ≥98% CAS No(883986-34-3) by Aladdin Scientific

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주문 가능

GRADE & PURITY ≥98%

Synonyms

AZD2932 | AZD-2932 | MS-28100 | A14156 | AC-33005 | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide | Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]- | AZD 2932 | CCG-2692

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 솔루션 계산기 리뷰

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

Information

AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor withIC50of 8 nM, 4 nM, 7 nM, and 9 nM forVEGFR-2,PDGFRβ,Flt-3, andc-Kit, respectively.

Targets

PDGFRβ ; Flt3 ; VEGFR-2 ; c-Kit 4 nM; 7 nM; 8 nM; 9 nM

In vitro

AZD2932 effectively inhibits the activities of VEGFR-2 (IC50, 8 nM), PDGFRβ (IC50,4 nM), Flt-3 (IC50, 7 nM), and c-Kit (IC50, 9 nM). AZD2932 inhibits both PDGFRα and PDGFRβ phosphorylation with a correlation close to 1:1. AZD2932 does not inhibit the various cytochrome P450 isoforms with the worst IC50 being against 2C9 (8.0 μM). AZD2932 has no activity against hERG (IC50, 137 μM).

In vivo

In C6 rat glial tumor model, AZD2932 (p.o., b.i.d.) results in signiﬁcant TGI of 64% for both 50 and 12.5 mg/kg doses. Growth of Calu-6 tumor is inhibited by 81% and 72% at 50 and 12.5 mg/kg b.i.d. (p.o.) and LoVo tumors by 67% at 50 mg/kg b.i.d (p.o.). AZD2932 (3–50 mg/kg, p.o.) causes 60–80% inhibition of both p-VEGFR-2 and p-PDGFRβ. Single bolus oral doses of AZD2932 results in dose-related inhibition of PDGFRa phosphorylation 6 h after dosing.

Specifications

동의어

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

Pubchem Sid	504766503
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766503
정식 스마일	CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC
IUPAC Name	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide
InChIKey	TWYCZJMOEMMCGC-UHFFFAOYSA-N
INCHI	1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
이성체 SMILES	CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC
분자량	447.49
Reaxy-Rn	12592093
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12592093&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - 분류 Organooxygen compounds
    - Subclass Ethers

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
분류	Organooxygen compounds
Subclass	Ethers
Intermediate Tree Nodes	Not available
Direct Parent	Diarylethers
Alternative Parents	Quinazolines Phenylacetamides Phenoxy compounds N-arylamides Anisoles Alkyl aryl ethers Pyrimidines and pyrimidine derivatives Pyrazoles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Diaryl ether - Phenylacetamide - Quinazoline - Phenoxy compound - Anisole - N-arylamide - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Pyrimidine - Azole - Heteroaromatic compound - Pyrazole - Carboxamide group - Secondary carboxylic acid amide - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organonitrogen compound - Organic oxide - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

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리뷰

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Lot Number	Certificate Type	날짜	항목
L2418196	Certificate of Analysis	Sep 21, 2026	A413703
K2217018	Certificate of Analysis	Aug 15, 2022	A413703
K2217019	Certificate of Analysis	Aug 15, 2022	A413703
K2217020	Certificate of Analysis	Aug 15, 2022	A413703
K2217021	Certificate of Analysis	Aug 15, 2022	A413703
K2217022	Certificate of Analysis	Aug 15, 2022	A413703

용해성	Solubility (25°C) In vitro DMSO: 89 mg/mL warmed with 50ºC Water: bath (198.88 mM); Ethanol: 5 mg/mL warmed with 50ºC Water: bath (11.17 mM); Water: Insoluble;
분자량	447.500 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	447.191 Da
Monoisotopic Mass	447.191 Da
Topological Polar Surface Area	100.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	630.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1