CH7233163 - ≥98% , CAS No.C414469

CAS: C414469 Cat. No.: C414469 분자식: C₃₁H₃₄F₃N₉O₃S 분자량: 669.72

GRADE & PURITY ≥98%

Synonyms

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Information

CH7233163 is a non-covalent ATP competitive inhibitor ofEGFR-tyrosine kinasewith antitumor activities against tumor with EGFR-Del19/T790M/C797S.

Targets

EGFR

In vitro

CH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro. CH7233163 potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. CH7233163 potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 can inhibit Del19/T790M/C797S signaling.

In vivo

Pharmacodynamic study is performed using Del19/T790M/C797S_NIH3T3 xenografted tumors in mice. CH7233163 clearly inhibits EGFR phosphorylation after oral administration and potent tumor regression is observed. CH7233163 has potent therapeutic efficacy against tumors with EGFR-Del19/T790M/C797S in vivo.

Cell Research(from reference)

Cell lines：NIH3T3 cells (ATCC) 

Concentrations：8 nM, 40 nM, 200 nM, 1000 nM 

Incubation Time：0.5 h-24 h, 4-7 days 

Specifications

동의어

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

• 분자량: 669.72

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 100 mg/mL (149.31 mM); Water: Insoluble; Ethanol: Insoluble